Journal ArticleDOI
Carbocycles from donor–acceptor cyclopropanes
TLDR
This review summarizes research directed towards the formation of carbocyclic adducts from donor-acceptor cyclopropanes and focuses on annulation and cycloaddition reactions mediated by Lewis or protic acid, bases, or thermal conditions.Abstract:
This review summarizes research directed towards the formation of carbocyclic adducts from donor–acceptor cyclopropanes. The focus of the review is on annulation and cycloaddition reactions (both inter- and intramolecularly) mediated by Lewis or protic acid, bases, or thermal conditions. Rearrangements resulting in carbocycles and those reactions mediated by transition metal catalysis have been excluded.read more
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Application of oxygen/nitrogen substituted donor-acceptor cyclopropanes in the total synthesis of natural products
TL;DR: In this paper, a review summarises the applications of heteroatom substituted donor-acceptor cyclopropanes in the total synthesis of natural products, including cycloaddition, rearrangement and cascade reactions.
Journal ArticleDOI
Recent Advances in Ring-opening of Donor Acceptor Cyclopropanes using C-Nucleophiles
Koena Ghosh,Subhomoy Das +1 more
TL;DR: Ring-opening transformations of donor-acceptor cyclopropanes (DAC) with carbon-centered nucleophiles is a simple, straight-forward approach to 1,3-bifunctional compounds that has witnessed remarkable progress over the past several years.
Journal ArticleDOI
Divergent Reactivity of Thioalkynes in Lewis Acid Catalyzed Annulations with Donor-Acceptor Cyclopropanes.
TL;DR: New annulation reactions of thioalkynes with phthalimide-substituted donor-acceptor cyclopropanes gave access to highly substituted cyclopentenes and polycyclic ring systems.
Journal ArticleDOI
Lewis Acid Catalyzed Enantioselective Desymmetrization of Donor-Acceptor meso-Diaminocyclopropanes.
TL;DR: The first Lewis acid catalyzed enantioselective ring-opening desymmetrization of a donor-acceptor meso-diaminocyclopropane is reported, which delivered enantioenriched, diastereomerically pure urea products.
Journal ArticleDOI
Multicomponent 1,3-Bifunctionalization of Donor-Acceptor Cyclopropanes with Arenes and Nitrosoarenes.
TL;DR: AlBr3-mediated multicomponent 1,3-bifunctionalization of donor-acceptor cyclopropanes using arenes and nitrosoarenes as coupling partners is presented and the γ,γ-disubstituted N-arylated α-amino esters obtained as products are readily further chemically modified rendering the method valuable.
References
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Journal ArticleDOI
Telmisartan, Ramipril, or Both in Patients at High Risk for Vascular Events
Koon K. Teo,Janice Pogue,Leanne Dyal,Ingrid Copland,Helmut Schumacher,Gilles R. Dagenais,Craig S. Anderson +6 more
TL;DR: Telmisartan was equivalent to ramipril in patients with vascular disease or high-risk diabetes and was associated with less angioedema and a increased risk of hypotensive symptoms.
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Donor-acceptor-substituted cyclopropane derivatives and their application in organic synthesis.
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Transition metal chemistry of cyclopropenes and cyclopropanes.
Journal ArticleDOI
Use of cyclopropanes and their derivatives in organic synthesis
Journal ArticleDOI
A new golden age for donor-acceptor cyclopropanes.
TL;DR: This Review highlights the appropriate tools for successfully employing donor-acceptor cyclopropanes in ring-opening reactions, cycloadditions, and rearrangements.
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