Journal ArticleDOI
Carbohydrate responsive element-binding protein (ChREBP): a key regulator of glucose metabolism and fat storage.
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TLDR
Feeding a high carbohydrate diet induces transcription of more than 15 genes involved in the metabolic conversion of glucose to fat, and a new transcription factor binding to a glucose response element of the pyruvate kinase and lipogenesis enzyme genes was discovered recently.About:
This article is published in Biochemical Pharmacology.The article was published on 2002-06-15. It has received 191 citations till now. The article focuses on the topics: Xylulose 5-phosphate & Response element.read more
Citations
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Bile Acid Signaling in Metabolic Disease and Drug Therapy
Tiangang Li,John Y.L. Chiang +1 more
TL;DR: An interaction of liver bile acids and gut microbiota in the regulation of liver metabolism and potential therapeutic agents for treating metabolic diseases of the liver are revealed.
Journal ArticleDOI
Transcriptional control of adipose lipid handling by IRF4.
Jun Eguchi,Xun Wang,Songtao Yu,Erin E. Kershaw,Patricia C. Chiu,Joanne R. Dushay,Jennifer L. Estall,Ulf Klein,Eleftheria Maratos-Flier,Evan D. Rosen +9 more
TL;DR: It is shown that interferon regulatory factor 4 (IRF4) is a critical determinant of the transcriptional response to nutrient availability in adipocytes and the disposition of calories in adipose tissue, with consequences for systemic metabolic homeostasis.
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Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance
TL;DR: Evidence is provided that hepatic steatosis has a causal role in the development of insulin resistance in other tissues, such as skeletal muscle, and recent advances in the understanding of how Steatosis alters hepatokine secretion to influence metabolic phenotypes through inter-organ communication are discussed.
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Effect of Fructose Overfeeding and Fish Oil Administration on Hepatic De Novo Lipogenesis and Insulin Sensitivity in Healthy Men
David Faeh,Kaori Minehira,Jean-Marc Schwarz,Jean-Marc Schwarz,Raj Periasamy,Seongsoo Park,Luc Tappy +6 more
TL;DR: In conclusion, high-fructose diet induced dyslipidemia and hepatic and adipose tissue insulin resistance and fish oil reversed dys Lipidemia but not insulin resistance.
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Nutritional genomics: the next frontier in the postgenomic era
Jim Kaput,Raymond L. Rodriguez +1 more
TL;DR: The interface between the nutritional environment and cellular/genetic processes is being referred to as "nutrigenomics" and it is presented that the progression from a healthy phenotype to a chronic disease phenotype must occur by changes in gene expression or by differences in activities of proteins and enzymes.
References
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Journal ArticleDOI
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
TL;DR: A procedure for preparing extracts from nuclei of human tissue culture cells that directs accurate transcription initiation in vitro from class II promoters, including tRNA and Ad 2 VA, is developed.
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The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor
TL;DR: This research was supported by grants from the National Institutes of Health (HL20948) and the Perot Family Foundation.
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A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver
Hiromi Yamashita,Makoto Takenoshita,Masaharu Sakurai,Richard K. Bruick,William J. Henzel,Wendy Shillinglaw,David Arnot,Kosaku Uyeda +7 more
TL;DR: The purification and identification of a transcription factor that recognizes the carbohydrate response element (ChRE) within the promoter of the L-type pyruvate kinase (LPK) gene is reported, suggesting a possible mode of glucose-responsive regulation.
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ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation.
TL;DR: The screening of an adipocyte cDNA expression library suggests that ADD1 plays a role in the regulation of determination- and differentiation-specific gene expression in adipocytes.
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Sterol Regulatory Element-binding Proteins (SREBPs): Key Regulators of Nutritional Homeostasis and Insulin Action
TL;DR: The sterol regulatory element-binding proteins (SREBPs) were first identified by two groups working independently on cholesterol metabolism and fat cell differentiation and have a unique dual DNA binding specificity, which is discussed below.
Related Papers (5)
New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c.
Fabienne Foufelle,Pascal Ferré +1 more