Journal ArticleDOI
Cerebrospinal fluid and serum d-serine concentrations are unaltered across the whole clinical spectrum of Alzheimer's disease.
Tommaso Nuzzo,Mattia Miroballo,Alessia Casamassa,Andrea Mancini,Lorenzo Gaetani,Robert Nisticò,Paolo Eusebi,Masumi Katane,Hiroshi Homma,Paolo Calabresi,Francesco Errico,Lucilla Parnetti,Alessandro Usiello +12 more
TLDR
The results failed to confirm previous findings indicating the CSF d-serine as a novel biomarker for AD, and instead measured blood serum and CSF concentration of two NMDAR modulators, such as d-Serine and d-aspartate, in a cohort of drug-free subjects encompassing the whole AD clinical spectrum.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2020-12-01. It has received 17 citations till now. The article focuses on the topics: Blood serum & Cerebrospinal fluid.read more
Citations
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Journal ArticleDOI
The Role of D-Amino Acids in Alzheimer's Disease.
TL;DR: In this paper, the experimental findings linking D-serine and D-aspartate, through NMDA receptor modulation, to AD and cognitive functions, were reported, which was also associated with the enzymes related to D-amino acid metabolism as well as with glucose and serine metabolism.
Journal ArticleDOI
New Evidence on the Role of D-Aspartate Metabolism in Regulating Brain and Endocrine System Physiology: From Preclinical Observations to Clinical Applications.
Alessandro Usiello,Maria Maddalena Di Fiore,Arianna De Rosa,Sara Falvo,Francesco Errico,Alessandra Santillo,Tommaso Nuzzo,Gabriella Chieffi Baccari +7 more
TL;DR: The physiological function of free D-Asp and of its metabolizing enzyme in regulating the functions of the brain and of the neuroendocrine system are reviewed based on recent genetic and pharmacological human and animal studies.
Journal ArticleDOI
An Overview of the Involvement of D-Serine in Cognitive Impairment in Normal Aging and Dementia
TL;DR: In this paper, the authors reviewed evidence from both preclinical and human studies on the involvement of D-serine (and the enzymes involved in its metabolism) in regulation of cognition.
Journal ArticleDOI
d-Amino Acids and pLG72 in Alzheimer’s Disease and Schizophrenia
TL;DR: In this paper, a review summarizes the roles of d-amino acids and pLG72, also known as damino acid oxidase activator, on two neurodegenerative disorders, schizophrenia and Alzheimer's disease (AD).
Journal ArticleDOI
Novel Biomarkers of Alzheimer's Disease: Based Upon N-methyl-D-aspartate Receptor Hypoactivation and Oxidative Stress
TL;DR: In this article, the N-methyl-D-aspartate receptor (NMDAR) activation plays an important role in learning and memory, and the NMDAR function is associated with anti-oxidation.
References
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Journal ArticleDOI
Clinical diagnosis of Alzheimer's disease : report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
TL;DR: The criteria proposed are intended to serve as a guide for the diagnosis of probable, possible, and definite Alzheimer's disease; these criteria will be revised as more definitive information becomes available.
Journal ArticleDOI
Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TL;DR: The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.
Journal ArticleDOI
NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease
Clifford R. Jack,David A. Bennett,Kaj Blennow,Maria C. Carrillo,Billy Dunn,Samantha Budd Haeberlein,David M. Holtzman,William J. Jagust,Frank Jessen,Jason Karlawish,Enchi Liu,José Luis Molinuevo,Thomas J. Montine,Creighton H. Phelps,Katherine P. Rankin,Christopher C. Rowe,Philip Scheltens,Eric Siemers,Heather M. Snyder,Reisa A. Sperling,Cerise L Elliott,Eliezer Masliah,Laurie M. Ryan,Nina Silverberg +23 more
TL;DR: This research framework seeks to create a common language with which investigators can generate and test hypotheses about the interactions among different pathologic processes (denoted by biomarkers) and cognitive symptoms and envision that defining AD as a biological construct will enable a more accurate characterization and understanding of the sequence of events that lead to cognitive impairment that is associated with AD.
Journal ArticleDOI
Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders
TL;DR: Perturbations in the balance between synaptic and extrasynaptic NMDAR activity contribute to neuronal dysfunction in acute ischaemia and Huntington's disease, and could be a common theme in the aetiology of neurodegenerative diseases.
Journal ArticleDOI
How common are the “common” neurologic disorders?
Deborah Hirtz,David J. Thurman,Katrina Gwinn-Hardy,M. Mohamed,A. R. Chaudhuri,Robert Zalutsky +5 more
TL;DR: Using the best available data, a survey of a limited number of disorders shows that the burden of neurologic illness affects many millions of people in the United States.