Journal ArticleDOI
Cerebrospinal fluid interleukin 6 in amyotrophic lateral sclerosis: immunological parameter and comparison with inflammatory and non-inflammatory central nervous system diseases
Tsuyoshi Sekizawa,Harry Openshaw,Kazuyuki Ohbo,Kazuo Sugamura,Yasuto Itoyama,Joyce C. Niland +5 more
Reads0
Chats0
TLDR
The elevated IL- 6 in ALS may reflect an ongoing humoral immune response, or IL-6 may be non-specifically expressed in these patients as a putative neurotrophic factor in response to nerve cell degeneration.About:
This article is published in Journal of the Neurological Sciences.The article was published on 1998-02-05. It has received 152 citations till now. The article focuses on the topics: Cerebrospinal fluid & Central nervous system disease.read more
Citations
More filters
Journal ArticleDOI
Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases.
TL;DR: Current understanding of the involvement of cytokines in neurodegenerative disorders and their potential signaling mechanisms are summarized to suggest that microglial activation and pro-inflammatory cytokines merit interest as targets in the treatment of neurodegnerative disorders.
Journal ArticleDOI
Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue.
Jenny S. Henkel,Joseph I. Engelhardt,László Siklós,Ericka Simpson,Seung Hyun Kim,Tianhong Pan,J. Clay Goodman,Teepu Siddique,David R. Beers,Stanley H. Appel +9 more
TL;DR: In this article, the authors examined mRNA expression of dendritic cell surface markers in individual sporadic ALS (sALS), familial ALS (fALS), and nonneurological disease control (NNDC) spinal cord tissues using semiquantitative and real-time reverse transcription polymerase chain reaction (RT-PCR).
Journal ArticleDOI
Inflammatory processes in amyotrophic lateral sclerosis.
P. L. McGeer,E. G. McGeer +1 more
TL;DR: Anti‐inflammatory agents may have a role to play in treating ALS, and COX‐2 is a particularly attractive target because of its marked increase in ALS spinal cord.
Journal ArticleDOI
Minocycline Slows Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis
TL;DR: Results indicate that minocycline, which is clinically well tolerated, may represent a novel and effective drug for treatment of ALS.
Journal ArticleDOI
Molecular and cellular pathways of neurodegeneration in motor neurone disease.
TL;DR: There is new evidence that non-neuronal cells in the vicinity of motor neurones may contribute to neuronal injury and the final demise ofMotor neurones is likely to involve a programmed cell death pathway resembling apoptosis.
References
More filters
Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial
D. W. Paty,David Kb Li +1 more
TL;DR: The MRI results demonstrate that IFNB has made a significant impact on the natural history of MS in these patients and support the clinical results in showing a significant reduction in disease activity as measured by numbers of active scans and appearance of new lesions.
Journal ArticleDOI
Principles of albumin and IgG analyses in neurological disorders. I. Establishment of reference values.
G. Tibbling,H. Link,S. Öhman +2 more
TL;DR: A proposed graphical presentation of CSF/S albumin and IgG-index may facilitate the interpretation of these parameters in routine clinical work.
Journal ArticleDOI
On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases.
Karl Frei,Ursula Malipiero,Thomas Leist,Rolf M. Zinkernagel,Martin E. Schwab,Adriano Fontana +5 more
TL;DR: IL 6 induced an increase of the secretion of a neurotrophic factor, nerve growth factor by astrocytes, which may be part of the host response to infection favoring immune‐mediated elimination of the infectious agent as well as trophic support for neurons.
Journal ArticleDOI
Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2).
Toshio Hirano,Tetsuya Taga,Naoko Nakano,Kiyosi Yasukawa,Shin-ichiro Kashiwamura,Kazuo Shimizu,Koichi Nakajima,Kwang H. Pyun,Tadamitsu Kishimoto +8 more
TL;DR: It is proposed that the BCDF that induces the final differentiation of B cells into high-rate Ig-secreting cells be designated BSFp-2, which did not show any activity of interleukin 1 or 2, B-cell stimulatory factor (BSF)p-1,B-cell growth factor II (BCGF-II), or interferon.