Journal ArticleDOI
CERR: A computational environment for radiotherapy research
TLDR
CERR provides a powerful, convenient, and common framework which allows researchers to use common patient data sets, and compare and share research results.Abstract:
A software environment is described, called the computational environment for radiotherapy research (CERR, pronounced "sir"). CERR partially addresses four broad needs in treatment planning research: (a) it provides a convenient and powerful software environment to develop and prototype treatment planning concepts, (b) it serves as a software integration environment to combine treatment planning software written in multiple languages (MATLAB, FORTRAN, C/C++, JAVA, etc.), together with treatment plan information (computed tomography scans, outlined structures, dose distributions, digital films, etc.), (c) it provides the ability to extract treatment plans from disparate planning systems using the widely available AAPM/RTOG archiving mechanism, and (d) it provides a convenient and powerful tool for sharing and reproducing treatment planning research results. The functional components currently being distributed, including source code, include: (1) an import program which converts the widely available AAPM/RTOG treatment planning format into a MATLAB cell-array data object, facilitating manipulation; (2) viewers which display axial, coronal, and sagittal computed tomography images, structure contours, digital films, and isodose lines or dose colorwash, (3) a suite of contouring tools to edit and/or create anatomical structures, (4) dose-volume and dose-surface histogram calculation and display tools, and (5) various predefined commands. CERR allows the user to retrieve any AAPM/RTOG key word information about the treatment plan archive. The code is relatively self-describing, because it relies on MATLAB structure field name definitions based on the AAPM/RTOG standard. New structure field names can be added dynamically or permanently. New components of arbitrary data type can be stored and accessed without disturbing system operation. CERR has been applied to aid research in dose-volume-outcome modeling, Monte Carlo dose calculation, and treatment planning optimization. In summary, CERR provides a powerful, convenient, and common framework which allows researchers to use common patient data sets, and compare and share research results.read more
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Journal ArticleDOI
Data for TROTS - The Radiotherapy Optimisation Test Set.
TL;DR: The Radiotherapy Optimisation Test Set (TROTS) is an extensive set of problems originating from radiotherapy (radiation therapy) treatment planning, designed to investigate the multi-criteria optimisation and decision-making nature of the radiotherapy problem.
Journal ArticleDOI
Distinct effects of rectum delineation methods in 3D-confromal vs. IMRT treatment planning of prostate cancer
TL;DR: Both the rectal filling and the anatomy of the seminal vesicles influenced the relationship between the dose parameters: a significant correlation of the difference between DVH and DWH and the Rectal volume was seen in IMRT treatment.
Journal ArticleDOI
Machine learning-based prediction of microsatellite instability and high tumor mutation burden from contrast-enhanced computed tomography in endometrial cancers.
Harini Veeraraghavan,Claire F. Friedman,Claire F. Friedman,Deborah F. DeLair,Deborah F. DeLair,Josip Nincevic,Yuki Himoto,Silvio G. Bruni,Silvio G. Bruni,Giovanni Cappello,Iva Petkovska,Stephanie Nougaret,Stephanie Nougaret,Stephanie Nougaret,Ines Nikolovski,Ahmet Zehir,Nadeem R. Abu-Rustum,Carol Aghajanian,Carol Aghajanian,Dmitriy Zamarin,Dmitriy Zamarin,Karen Cadoo,Karen Cadoo,Luis A. Diaz,Luis A. Diaz,Mario M. Leitao,Vicky Makker,Vicky Makker,Robert A. Soslow,Jennifer J. Mueller,Britta Weigelt,Yulia Lakhman +31 more
TL;DR: Radiomic analysis achieved moderate accuracy in identifying MMR-D and TMB-H ECs directly from CE-CT and may provide an adjunct tool to molecular profiling, especially given its potential advantage in the setting of intratumor heterogeneity.
Journal ArticleDOI
A prospective study of differences in duodenum compared to remaining small bowel motion between radiation treatments: Implications for radiation dose escalation in carcinoma of the pancreas
Anurag K. Singh,Ryan M. Tierney,Daniel A. Low,Parag J. Parikh,Robert J. Myerson,Joseph O. Deasy,Catherine S Wu,G Pereira,Sasha H. Wahab,Sasa Mutic Ms,Perry W. Grigsby,Andrew J. Hope +11 more
TL;DR: The volume of small bowel irradiated during four-field pancreatic radiation therapy changes substantially between fractions, which suggests dose escalation may be possible, however, dose limits to the duodenum should be stricter than for other segments ofsmall bowel.
Journal ArticleDOI
The influence of patient positioning uncertainties in proton radiotherapy on proton range and dose distributions.
TL;DR: The present work quantitatively analyzes the influence of setup uncertainties on proton range and dose distributions in therapy of small lesions in the human brain as well as target and OAR dosimetry.
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Journal Article
Extending python with Fortran
Paul F. Dubois,T.-Y. Yang +1 more
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