Chapparvoviruses occur in at least three vertebrate classes and have a broad biogeographic distribution
William Marciel de Souza,William Marciel de Souza,Marilia Farignoli Romeiro,Marcílio Jorge Fumagalli,Sejal Modha,Jansen de Araujo,Luzia Helena Queiroz,Edison Luiz Durigon,Luiz Tadeu Moraes Figueiredo,Pablo R. Murcia,Robert J. Gifford +10 more
TLDR
The sequences of six novel chapparvoviruses identified through both metagenomic sampling of bat tissues and in silico screening of published vertebrate genome assemblies group together as a robustly supported monophyletic clade in phylogenetic trees.Abstract:
Chapparvoviruses are a highly divergent group of parvoviruses (family Parvoviridae) that have recently been identified via metagenomic sampling of animal faeces. Here, we report the sequences of six novel chapparvoviruses identified through both metagenomic sampling of bat tissues and in silico screening of published vertebrate genome assemblies. The novel chapparvoviruses share several distinctive genomic features and group together as a robustly supported monophyletic clade in phylogenetic trees. Our data indicate that chapparvoviruses have a broad host range in vertebrates and a global distribution.read more
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Reorganizing the family Parvoviridae: a revised taxonomy independent of the canonical approach based on host association.
Judit J Pénzes,Maria Söderlund-Venermo,Marta Canuti,Anna Maria Eis-Hübinger,Joseph Hughes,Susan F. Cotmore,Balázs Harrach +6 more
TL;DR: A new and updated system for parvovirus classification is presented, which includes the introduction of a third subfamily, Hamaparvovirinae, resolves the paraphyly within genus Ambidensovirus, and introduces new genera and species into the subfamily ParvovIRinae.
Journal ArticleDOI
An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis
Ben Roediger,Quintin Lee,Shweta Tikoo,Joanna C. A. Cobbin,James M. Henderson,Mika Jormakka,Matthew B. O'Rourke,Matthew B. O'Rourke,Matthew P. Padula,Natalia Pinello,Marisa Henry,Maria Wynne,Sara F Santagostino,Cory Brayton,Lorna Rasmussen,Leszek Lisowski,Szun S. Tay,David Harris,John F. Bertram,John P. Dowling,Patrick Bertolino,Jack H. Lai,Wengen Wu,William W. Bachovchin,Justin J.-L. Wong,Mark D. Gorrell,Babak Shaban,Edward C. Holmes,Christopher J. Jolly,Sebastien Monette,Wolfgang Weninger +30 more
TL;DR: A stepwise progression of pathology ranging from sporadic tubular inclusions to tubular degeneration and interstitial fibrosis and culminating in renal failure is demonstrated, establishing MKPV-induced nephropathy as a new tool for elucidating mechanisms of tubulointerstitial fibrosis that shares molecular features with chronic kidney disease in humans.
Journal ArticleDOI
An Ancient Lineage of Highly Divergent Parvoviruses Infects both Vertebrate and Invertebrate Hosts.
TL;DR: The findings demonstrate that the ChPV lineage infects an exceptionally broad range of host species, including both vertebrates and invertebrates, and suggests that transmission between distantly related host species may have occurred in the past and that the Parvoviridae family can no longer be divided based on host affiliation.
Journal ArticleDOI
Virome heterogeneity and connectivity in waterfowl and shorebird communities.
TL;DR: Complex virome structures across host species that co-exist in multi-species aggregations are demonstrated and are indicative of both virome connectivity (host sharing) and heterogeneity (host specificity).
Journal ArticleDOI
Faecal Virome Analysis of Wild Animals from Brazil.
Matheus Almeida Duarte,João Marcos Fagundes Silva,Clara R. Brito,Danilo Simonini Teixeira,Fernando L. Melo,Bergmann Morais Ribeiro,Tatsuya Nagata,Fabrício Souza Campos +7 more
TL;DR: It is demonstrated that the metagenomics approach applied in this work was effective for identification of known and putative new viruses in faeces samples from Brazilian Cerrado fauna.
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