Characteristics of an immune system common to certain external secretions
TLDR
The γ1A present in saliva and colostrum exists largely in the form of higher polymers, the major component of which has a sedimentation coefficient of 11S, and its properties including the local production of a distinctive type of antibody separate it from the "systemic" system responsible for the production of circulating antibody.Abstract:
The γ1A present in saliva and colostrum exists largely in the form of higher polymers, the major component of which has a sedimentation coefficient of 11S. The 11S γ1A in these fluids differs from the polymers found in normal and myeloma sera both immunologically and by the fact that their sedimentation coefficients are unaffected by disulfide bond reduction in the absence of urea. However, like other γ-globulins the 11S γ1A molecules consist of multiple polypeptide chains linked by disulfide bonds. Local synthesis of γ1A in the salivary gland has been shown by fluorescent and autoradiographic studies, although the fraction of the total salivary γ1A which is derived from local production is uncertain. No evidence of transport of intravenously administered I131-labeled 7S γ1A from serum to saliva was obtained. Immunological specificity has been demonstrated in the salivary and colostral γ1A. Whether that portion of the γ1A which is immunologically specific is a piece incorporated during the local synthesis of γ1A in the gland or is added by the epithelial cell in the process of transport remains to be determined. Antibody activity (isohemagglutinins) have been demonstrated in saliva and colostrum and have been shown to be of the γ1A-type. In both of these fluids activity is associated primarily with γ1A-polymers of 11S and 18S sizes. There appears to be an immunological system which is characteristic of certain external secretions. Its properties including the local production of a distinctive type of antibody separate it from the "systemic" system responsible for the production of circulating antibody. This system may play a significant role in the body's defense mechanisms against allergens and microorganisms.read more
Citations
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Hidden antigenic determinant in secretory immunoglobulin A.
TL;DR: This work attempted to produce a highly specific antiserum to the free secretory piece from human parotid secretions because antisera to the “piece”4–7,9,10 were antisersa to secretory IgA adsorbed with serum IgA.
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Dysgammaglobulinemic antibody deficiency syndrome
Armond S. Goldman,Stephan E. Ritzmann,Elsie W. Houston,Shirley Sidwell,Raymond L. Bratcher,William C. Levin +5 more
TL;DR: Detailed studies including chromosomal analysis are recorded for two male children with the dysgammaglobulinemic antibody deficiency syndrome.
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γA and non-γA immune response after oral and patenteral immunization of the hamster
Josef Dolezel,John Bienenstock +1 more
TL;DR: The available evidence suggests that the route of immunization and antigen distribution influences the commitment toγA antibody synthesis, and that extraintestinal γA synthesis may result from intestinal lymphoid tissue dissemination.
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A reliable method for the preparation of bovine secretory immunoglobulin A (SIgA) which circumvents problems posed by IgG1 dimers in colostrum.
TL;DR: Highly purified IgA can be obtained from BAW by a three step method involving the removal of contaminating α2-macroglobulin by ZnSO4 precipitation and is heterogeneous in its content of secretory component but free of contamination when assayed by a battery of immunochemical techniques.
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Vaccination Against Enteric Bacterial Diseases
David M. Hone,Jim Hackett +1 more
TL;DR: Evidence that the systemic and mucosal immune systems of the body are compartmentalized is reviewed and good progress has been made in the comprehension of the requirements for effective vaccination against enteropathogenic bacteria.
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