Characterization of the adipocyte cellular lineage in vivo
Ryan Berry,Matthew S. Rodeheffer +1 more
TLDR
A model where the CD24+ adipocyte progenitors become further committed to the adipocyte lineage as CD24 expression is lost, generating CD24− preadipocytes is proposed.Abstract:
Adipocytes have been suggested to arise from prospective progenitors of endothelial or haematopoietic origin. Rodeheffer and colleagues use lineage tracing to rule out that this is the case for white adipocytes, and show that they instead arise from CD24+ cells that are characterized by the expression of PdgfR (platelet-derived growth factor receptor).read more
Citations
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Brown and beige fat: development, function and therapeutic potential
Matthew J. Harms,Patrick Seale +1 more
TL;DR: Many genes and pathways that regulate brown and beige adipocyte biology have now been identified, providing a variety of promising therapeutic targets for metabolic disease.
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What We Talk About When We Talk About Fat
TL;DR: New perspective is gained on the roles played by adipocyte in a variety of homeostatic processes and on the mechanisms used by adipocytes to communicate with other tissues and how these relationships are altered during metabolic disease and how they might be manipulated to restore metabolic health.
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Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders.
TL;DR: Current mechanistic understandings of adipose tissue remodeling processes in adaptive energy homeostasis and pathological remodeling of adipOSE tissue in connection with immune response are discussed.
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Adipogenesis and metabolic health
TL;DR: Interestingly, adipose tissue expansion through the generation of new adipocytes (adipogenesis), rather than through increasing adipocyte size, can prevent this metabolic decline, and a better understanding of adipogenesis can inform new strategies to increase metabolic health in humans.
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Bi-directional interconversion of brite and white adipocytes
TL;DR: It is shown here that cold-induced formation of brite adipocytes in mice is reversed within 5 weeks of warm adaptation, but the brITE adipocytes formed by cold stimulation are not eliminated.
References
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Journal ArticleDOI
Multilineage cells from human adipose tissue: implications for cell-based therapies.
Patricia A. Zuk,Min Zhu,Hiroshi Mizuno,Jerry I. Huang,Futrell Jw,Adam J. Katz,Prosper Benhaim,H. P. Lorenz,Marc H. Hedrick +8 more
TL;DR: The data support the hypothesis that a human lipoaspirate contains multipotent cells and may represent an alternative stem cell source to bone marrow-derived MSCs.
Journal ArticleDOI
A global double‐fluorescent Cre reporter mouse
Mandar Deepak Muzumdar,Bosiljka Tasic,Bosiljka Tasic,Kazunari Miyamichi,Kazunari Miyamichi,Ling Li,Ling Li,Liqun Luo,Liqun Luo +8 more
TL;DR: The mT/mG mouse as mentioned in this paper is a double-fluorescent Cre reporter mouse that expresses membrane-targeted tandem dimer tomato (mT) prior to Cre-mediated excision and membranetargeted green fluorescent protein (mG) after excision.
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Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
Saverio Cinti,Grant A. Mitchell,Giorgio Barbatelli,Incoronata Murano,Enzo Ceresi,Emanuela Faloia,Shupei Wang,Mélanie Fortier,Andrew S. Greenberg,Martin S. Obin +9 more
TL;DR: It is demonstrated that >90% of all macrophages in WAT of obese mice and humans are localized to dead adipocytes, where they fuse to form syncytia that sequester and scavenge the residual “free” adipocyte lipid droplet and ultimately form multinucleate giant cells, a hallmark of chronic inflammation.
Journal ArticleDOI
Dynamics of fat cell turnover in humans
Kirsty L. Spalding,Erik Arner,Pål O. Westermark,Samuel Bernard,Bruce A. Buchholz,Olaf Bergmann,Lennart Blomqvist,Johan Hoffstedt,Erik Näslund,Tom Britton,Hernan Concha,Moustapha Hassan,Mikael Rydén,Jonas Frisén,Peter Arner +14 more
TL;DR: It is shown that adipocyte number is a major determinant for the fat mass in adults, however, the number of fat cells stays constant in adulthood in lean and obese individuals, even after marked weight loss, indicating that thenumber of adipocytes is set during childhood and adolescence.
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Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis
Aaron W. Joe,Lin Yi,Anuradha Natarajan,Fabien Le Grand,Leslie So,Joy X. Wang,Michael A. Rudnicki,Fabio M.V. Rossi +7 more
TL;DR: A new subpopulation of fibro/adipogenic progenitors (FAPs) resident in muscle tissue but arising from a distinct developmental lineage is described, which expand upon damage to provide a transient source of pro-differentiation signals for proliferating myogenic progensitors.