Journal ArticleDOI
Nanoenzyme-Augmented Cancer Sonodynamic Therapy by Catalytic Tumor Oxygenation.
Piao Zhu,Yu Chen,Jianlin Shi +2 more
TLDR
High in vivo biocompatibility and easy excretion of these multifunctional nanosonosensitizers from the body have been evaluated and demonstrated to guarantee their future clinical translation, and their TME-responsive T1-weighted magnetic resonance imaging capability provides the potential for therapeutic guidance and monitoring during SDT.Abstract:
Ultrasound (US)-triggered sonodynamic therapy (SDT) can solve the critical issue of low tissue-penetrating depth of traditional phototriggered therapies, but the SDT efficacy is still not satisfactorily high in combating cancer at the current stage. Here we report on augmenting the SDT efficacy based on catalytic nanomedicine, which takes the efficient catalytic features of nanoenzymes to modulate the tumor microenvironment (TME). The multifunctional nanosonosensitizers have been successfully constructed by the integration of a MnOx component with biocompatible/biodegradable hollow mesoporous organosilica nanoparticles, followed by conjugation with protoporphyrin (as the sonosensitizer) and cyclic arginine-glycine-aspartic pentapeptide (as the targeting peptide). The MnOx component in the composite nanosonosensitizer acts as an inorganic nanoenzyme for converting the tumor-overexpressed hydrogen peroxide (H2O2) molecules into oxygen and enhancing the tumor oxygen level subsequently, which has been demonst...read more
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Journal ArticleDOI
Reactive Oxygen Species (ROS)-Based Nanomedicine.
Bowen Yang,Yu Chen,Jianlin Shi +2 more
TL;DR: In this article, the intrinsic biochemical properties of reactive oxygen species (ROS) underlie the mechanisms that regulate various physiological functions of living organisms, and they play an essential role in regulating various physiological function.
Journal ArticleDOI
Multifunctional sonosensitizers in sonodynamic cancer therapy
Subin Son,Ji Hyeon Kim,Xianwen Wang,Chuangli Zhang,Shin A Yoon,Jinwoo Shin,Amit Sharma,Min Hee Lee,Liang Cheng,Jiasheng Wu,Jong Seung Kim +10 more
TL;DR: This review article highlights the recent advances in SDT in terms of sonosensitizers and their formulations and anticancer therapeutic efficacy and the potential ofSDT in combination with other modalities to address unmet needs in precision medicine.
Journal ArticleDOI
Nanocatalytic Tumor Therapy by Biomimetic Dual Inorganic Nanozyme-Catalyzed Cascade Reaction.
TL;DR: This study reports on the construction of an efficient biomimetic dual inorganic nanozyme‐based nanoplatform, which triggers cascade catalytic reactions for tumor microenvironment responsive nanocatalytic tumor therapy based on ultrasmall Au and Fe3O4 NPs coloaded dendritic mesoporous silica NPs.
Journal ArticleDOI
Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice
Wen-Wen Yue,Liang Chen,Luodan Yu,Bangguo Zhou,Bangguo Zhou,Haohao Yin,Haohao Yin,Wei-Wei Ren,Chang Liu,Le-Hang Guo,Yi-Feng Zhang,Li-Ping Sun,Kun Zhang,Hui-Xiong Xu,Yu Chen +14 more
TL;DR: A nanoparticle-based approach in combination with a TLR7 agonist and sonodynamic therapy is used, and it is found that when used together with anti-PD-L1, tumour formation and metastases are impacted.
Journal ArticleDOI
Intelligent Hollow Pt-CuS Janus Architecture for Synergistic Catalysis-Enhanced Sonodynamic and Photothermal Cancer Therapy.
Shuang Liang,Xiaoran Deng,Yun Chang,Chunqiang Sun,Shuai Shao,Zhongxi Xie,Zhongxi Xie,Xiao Xiao,Xiao Xiao,Ping'an Ma,Haiyuan Zhang,Haiyuan Zhang,Ziyong Cheng,Ziyong Cheng,Jun Lin,Jun Lin +15 more
TL;DR: A novel Pt-CuS Janus composed of hollow semiconductor CuS and noble metallic Pt was rationally designed and successfully synthesized and develops a versatile nanoplatform for a multifunctional theranostic strategy and broadens the biological applications by rationally designing their structure.
References
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