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Journal ArticleDOI

Chikungunya, an epidemic arbovirosis.

TLDR
Chikungunya is an arboviral disease transmitted by aedes mosquitoes and was first isolated in 1953 in Tanzania as mentioned in this paper, where it is a specifi cally tropical disease, but it is geographically restricted and outbreaks are relatively uncommon.
Abstract
Chikungunya is an arboviral disease transmitted by aedes mosquitoes. The virus was fi rst isolated in 1953 in Tanzania. Chikungunya virus is a member of the genus Alphavirus and the family Togaviridae. The disease typically consists of an acute illness characterised by fever, rash, and incapacitating arthralgia. The word chikungunya, used for both the virus and the disease, means “to walk bent over” in some east African languages, and refers to the eff ect of the joint pains that characterise this dengue-like infection. Chikungunya is a specifi cally tropical disease, but it is geographically restricted and outbreaks are relatively uncommon. It is only occasionally observed in travellers and military personnel. More than 266 000 people have been infected during the ongoing outbreak in Reunion, in which Aedes albopictus is the presumed vector. In the ongoing Indian outbreak, in which Aedes aegypti is the presumed vector, 1 400 000 cases of chikungunya were reported during 2006. The reasons for the re-emergence of chikungunya on the Indian subcontinent, and for its unprecedented incidence rate in the Indian Ocean region, are unclear. Plausible explanations include increased tourism, chikungunya virus introduction into a naive population, and viral mutation.

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Infection with chikungunya virus in Italy: an outbreak in a temperate region

TL;DR: In this article, an outbreak of chikungunya virus (CHIKV) was reported in Italy, where the primary source of infection and modes of transmission were identified and an active surveillance system was also implemented.
Journal ArticleDOI

Refining the global spatial limits of dengue virus transmission by evidence-based consensus

TL;DR: A contemporary global map of national-level dengue status is generated that assigns a relative measure of certainty and identifies gaps in the available evidence and provides a preliminary estimate of population at risk with an upper bound of 3.97 billion people.
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A single mutation in chikungunya virus affects vector specificity and epidemic potential.

TL;DR: The observation that a single amino acid substitution can influence vector specificity provides a plausible explanation of how this mutant virus caused an epidemic in a region lacking the typical vector, and has important implications with respect to how viruses may establish a transmission cycle when introduced into a new area.
Journal ArticleDOI

Chikungunya Fever: An Epidemiological Review of a Re-Emerging Infectious Disease

TL;DR: The epidemiology and global expansion of CHIKV is characterized, the clinical features and laboratory testing for the disease are described, and priorities for further studies needed for effective disease control and prevention are discussed.
Journal ArticleDOI

Biology and pathogenesis of chikungunya virus

TL;DR: This Review highlights some of the most recent advances in understanding of the biology of CHIKV and its interactions with the host.
References
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Journal ArticleDOI

The alphaviruses: gene expression, replication, and evolution.

TL;DR: This article corrects the article on p. 496 in vol.
Journal ArticleDOI

Critical review of the vector status of Aedes albopictus

TL;DR: Examination of the extensive literature indicates that Ae.
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