Clathrin senses membrane curvature
Wade F. Zeno,Wade F. Zeno,Jacob B. Hochfelder,Ajay S. Thatte,Liping Wang,Avinash K. Gadok,Carl C. Hayden,Eileen M. Lafer,Jeanne C. Stachowiak +8 more
TLDR
The ability of proteins to assemble at sites of high membrane curvature is essential to diverse membrane remodeling processes, including clathrin-mediated endocytosis Multiple adaptor proteins within the Clathrin pathway have been shown to sense regions of high curvature, leading to local recruitment of the clathin coat as discussed by the authors.About:
This article is published in Biophysical Journal.The article was published on 2021-03-02 and is currently open access. It has received 22 citations till now. The article focuses on the topics: Clathrin coat & Clathrin.read more
Citations
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Journal ArticleDOI
The structure and spontaneous curvature of clathrin lattices at the plasma membrane.
Kem A. Sochacki,Bridgette L. Heine,Gideon J. Haber,John R. Jimah,Bijeta Prasai,Marco A. Alfonzo-Méndez,Aleah D. Roberts,Agila Somasundaram,Jenny E. Hinshaw,Justin W. Taraska +9 more
TL;DR: In this article, the shape and size parameters common to clathrin-mediated endocytosis were determined and a universal mechanistic model of the pathway was presented, and the curvature generation was attributed to loosely connected and pentagon-containing flat lattices that can rapidly curve when a flattening force is released.
Journal ArticleDOI
Recent developments in membrane curvature sensing and induction by proteins.
Chandra Has,S. Das +1 more
TL;DR: In this paper, the authors provide an overview of major classes of membrane proteins and the mechanisms of curvature sensing and induction, and discuss the importance of membrane elastic characteristics to induce the membrane shapes similar to intracellular organelles.
Journal ArticleDOI
Generation of nanoscopic membrane curvature for membrane trafficking
TL;DR: The fundamental mechanisms such as the hydrophobic insertion, scaffolding and crowding mechanisms these proteins use to produce membrane curvatures and complex shapes required to form intracellular organelles and vesicular structures involved in endocytosis and secretion are described.
Journal ArticleDOI
Imaging vesicle formation dynamics supports the flexible model of clathrin-mediated endocytosis
Tomasz Nawara,Yancey D Williams,Tejeshwar C. Rao,Yuesong Hu,Elizabeth Sztul,Khalid Salaita,Alexa L. Mattheyses +6 more
TL;DR: In this article , Zhao et al. quantified the nanoscale dynamics of clathrin-coat shape change during vesicle assembly and found that de novo accumulations generate both flat and curved structures.
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Induced nanoscale membrane curvature bypasses the essential endocytic function of clathrin
TL;DR: It is established that membrane curvature assists in CME nucleation and that the essential function of clathrin during CME is to facilitate curvature evolution, rather than scaffold protein recruitment.
References
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Journal ArticleDOI
Regulated portals of entry into the cell
Sean D. Conner,Sandra L. Schmid +1 more
TL;DR: ‘Endocytosis’ encompasses several diverse mechanisms by which cells internalize macromolecules and particles into transport vesicles derived from the plasma membrane and must be viewed in a broader context than simple vesicular trafficking.
Journal Article
The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves
Journal ArticleDOI
Molecular mechanism and physiological functions of clathrin-mediated endocytosis
TL;DR: Clathrin-mediated endocytosis is the endocytic portal into cells through which cargo is packaged into vesicles with the aid of a clathrin coat and is fundamental to neurotransmission, signal transduction and the regulation of many plasma membrane activities and is thus essential to higher eukaryotic life.
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BAR domains as sensors of membrane curvature: the amphiphysin BAR structure
Brian J. Peter,Helen M. Kent,Ian G. Mills,T. Yvonne Vallis,P. Jonathan G. Butler,Philip R. Evans,Harvey T. McMahon +6 more
TL;DR: The structure of the Drosophila amphiphysin BAR domain is solved and it is predicted that BAR domains are in many protein families, including sorting nexins, centaurins, and oligophrenins.
Journal ArticleDOI
Curvature of clathrin-coated pits driven by epsin
Marijn G. J. Ford,Ian G. Mills,Brian J. Peter,Yvonne Vallis,Gerrit J. K. Praefcke,Philip R. Evans,Harvey T. McMahon +6 more
TL;DR: It is shown here that epsin 1 directly modifies membrane curvature on binding to PtdIns(4,5)P2 in conjunction with clathrin polymerization, and it is proposed that this helix is inserted into one leaflet of the lipid bilayer, inducing curvature.