Clinical Course of 195 Critically Ill COVID-19 Patients: A Retrospective Multicenter Study.
Shuliang Zhou,Yadong Yang,Xingguo Zhang,Zhifeng Li,Xing Liu,Chang Hu,Chunxi Chen,Dawei Wang,Zhiyong Peng +8 more
Reads0
Chats0
TLDR
Ventilation support and hemodynamic support were the cornerstones for critical care and high viral load was associated with death of critically ill COVID-19 patients.Abstract:
INTRODUCTION: Coronavirus disease-2019 (COVID-19) outbreak has spread around the world. However, the dynamic course of critically ill COVID-19 has not been described thoroughly. PATIENTS AND METHODS: We retrospectively analyzed 195 critically ill COVID-19 patients in Hubei province, China, between January 5, 2020 and April 3, 2020. Epidemiologic data, clinical features, treatments, and outcomes were collected and analyzed. RESULTS: Most critically ill patients were older with higher Acute Physiology and Chronic Health Evaluation II scores. After critical illness onset, a total of 181 (92.8%) patients received ventilation support, of which 84 (43.1%) received noninvasive and 97 (49.7%) received invasive mechanic ventilation (IMV). Among the 97 patients with IMV, 28 (28.9%) received prone ventilation, 57 (58.8%) received neuromuscular blocked therapy, and 22 (11.3%) received tracheostomy due to prolonged ventilator use. Early hypoxemia, subsequent hypercapnia, pulmonary hypertension, and finally pulmonary fibrosis were notable in the clinical course of acute respiratory distress syndrome (ARDS). Eighty-nine (45.6%) patients presented with shock. Acute kidney injury (29.7%) and secondary infection (28.2%) were also notable. The overall mortality of critically ill patients at day 28 was 42.1%. Intensive care unit (ICU) mortality was around 33%, as 16 patients died prior to ICU admission. A low PaO2/FiO2 ratio was an independent risk factor for death. High viral load was observed in most non-survivors. CONCLUSION: ARDS and shock were notable in the critical illness of COVID-19. Ventilation support and hemodynamic support were the cornerstones for critical care. High viral load was associated with death of critically ill COVID-19 patients.read more
Citations
More filters
Journal ArticleDOI
Time-resolved systems immunology reveals a late juncture linked to fatal COVID-19.
Can Liu,Can Liu,Andrew J. Martins,William W. Lau,Nicholas Rachmaninoff,Nicholas Rachmaninoff,Jinguo Chen,Luisa Imberti,Darius Mostaghimi,Danielle Fink,Peter D. Burbelo,Kerry Dobbs,Ottavia M. Delmonte,Neha Bansal,Laura Failla,Alessandra Sottini,Eugenia Quiros-Roldan,Kyu Lee Han,Brian Sellers,Foo Cheung,Rachel Sparks,Tae Wook Chun,Susan Moir,Michail S. Lionakis,Michael S. Abers,Richard Apps,Marita Bosticardo,Pedro Milanez-Almeida,Matthew P. Mulé,Elana Shaw,Yu Zhang,Francesco Castelli,Maria Lorenza Muiesan,Gabriele Tomasoni,Francesco Scolari,Alessandra Tucci,Camillo Rossi,Helen C. Su,Douglas B. Kuhns,Jeffrey I. Cohen,Luigi D. Notarangelo,John S. Tsang +41 more
TL;DR: In this article, the authors longitudinally assessed circulating proteins as well as 188 surface protein markers, transcriptome, and T-cell receptor sequence simultaneously in single peripheral immune cells from COVID-19 patients.
Journal ArticleDOI
Coronavirus Disease 2019 as Cause of Viral Sepsis: A Systematic Review and Meta-Analysis.
Eleni Karakike,Evangelos J. Giamarellos-Bourboulis,Miltiades Kyprianou,Carolin Fleischmann-Struzek,Mathias W. Pletz,Mihai G. Netea,Konrad Reinhart,Evdoxia Kyriazopoulou +7 more
TL;DR: In this paper, the authors conducted a systematic review on the prevalence of coronavirus disease 2019-related sepsis among adults hospitalized in the ICU and the general ward.
Journal ArticleDOI
SARS-CoV-2 (COVID-19), viral load and clinical outcomes;lessons learned one year into the pandemic: A systematic review
TL;DR: SARS-CoV-2 (COVID-19), viral load and clinical outcomes; lessons learned one year into the pandemic: A systematic review as discussed by the authors, a systematic review
Journal ArticleDOI
Vitamin D and Lung Outcomes in Elderly COVID-19 Patients.
Alberto Sulli,E. Gotelli,Andrea Casabella,Sabrina Paolino,Carmen Pizzorni,Elisa Alessandri,Marco Grosso,Diego Ferone,Vanessa Smith,Maurizio Cutolo +9 more
TL;DR: In this paper, the 25OH-vitamin D serum concentrations with clinical parameters of lung involvement, in elderly patients hospitalized for SARS-CoV-2 infection, were analyzed, and significantly lower vitamin D serum levels were found in COVID-19 patients than in CNT.
Journal ArticleDOI
Clinical features and outcomes of critically ill patients with coronavirus disease 2019 (COVID-19): A multicenter cohort study.
Khalid Al Sulaiman,Khalid Al Sulaiman,Ohoud Aljuhani,Khalid Eljaaly,Aisha Alharbi,Adel M. Al Shabasy,Alawi S. Alsaeedi,Mashael Al Mutairi,Hisham A. Badreldin,Shmeylan Al Harbi,Hussain A. Al Haji,Omar I. Al Zumai,Ramesh Vishwakarma,Abdulmalik M. Alkatheri +13 more
TL;DR: In this paper, a multicenter, non-interventional cohort study for all critically ill patients aged 18 years or older, admitted to intensive care units (ICUs) between March 1 to August 31, 2020, with an objectively confirmed diagnosis of COVID-19.
References
More filters
Journal ArticleDOI
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
Journal ArticleDOI
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
Mervyn Singer,Clifford S. Deutschman,Christopher W. Seymour,Manu Shankar-Hari,Djillali Annane,Michael Bauer,Rinaldo Bellomo,Gordon R. Bernard,Jean-Daniel Chiche,Craig M. Coopersmith,Richard S. Hotchkiss,Mitchell M. Levy,John C. Marshall,Greg S. Martin,Steven M. Opal,Gordon D. Rubenfeld,Gordon D. Rubenfeld,Tom van der Poll,Jean Louis Vincent,Derek C. Angus +19 more
TL;DR: The task force concluded the term severe sepsis was redundant and updated definitions and clinical criteria should replace previous definitions, offer greater consistency for epidemiologic studies and clinical trials, and facilitate earlier recognition and more timely management of patients with sepsi or at risk of developing sepsic shock.
Journal ArticleDOI
Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study.
Xiaobo Yang,Yuan Yu,Jiqian Xu,Huaqing Shu,Jia'an Xia,Hong Liu,Hong Liu,Yongran Wu,Lu Zhang,Zhui Yu,Minghao Fang,Ting Yu,Yaxin Wang,Shangwen Pan,Xiaojing Zou,Shiying Yuan,You Shang,You Shang +17 more
TL;DR: The clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia who were admitted to the intensive care unit (ICU) of Wuhan Jin Yin-tan hospital between late December, 2019 and Jan 26, 2020 are described.