Journal ArticleDOI
Clinical, immunological, and virological effects of ampligen, a mismatched double-stranded RNA, in patients with AIDS or AIDS-related complex.
WilliamA. Carter,Isadore Brodsky,MichaelG. Pellegrino,HoraceF. Henriques,DavidM. Parenti,RichardS. Schulof,W. Edward Robinson,D. J. Volsky,Helene Paxton,Katalin Karikó,RobertJ. Suhadolnik,D. R. Strayer,Mark Lewin,Leo Einck,GaryL. Simon,RochelleG. Scheib,David C. Montefiori,William M. Mitchell,Deborah Paul,WilliamA. Meyer,Nancy L. Reichenbach,DavidH. Gillespie +21 more
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In the short term, ampligen seems to have the dual ability to restore immunological function and to control HIV replication.About:
This article is published in The Lancet.The article was published on 1987-06-06. It has received 127 citations till now. The article focuses on the topics: AIDS-related complex & HIV Antigens.read more
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Antibody-dependent enhancement of human immunodeficiency virus type 1 infection
TL;DR: Two components of human serum enhance human immunodeficiency virus type 1 (HIV-1) infection and mask HIV-1 neutralising antibody activity and the data suggest that the two components are antibody and the alternative pathway of complement fixation.
Journal ArticleDOI
Clinical pharmacology of 3'-azido-2',3'-dideoxythymidine (zidovudine) and related dideoxynucleosides.
TL;DR: The development of a rational therapy against the etiologic agent of the acquired immunodeficiency syndrome (AIDS) was made possible by the discovery that a cytopathic retrovirus, now called the human immunodficiency virus (HIV), caused the disorder.
Journal ArticleDOI
The 2-5A system: modulation of viral and cellular processes through acceleration of RNA degradation.
Mark R. Player,Paul F. Torrence +1 more
TL;DR: Additional possible biological roles of the 2–5A system, such as in cell growth and differentiation, human immunodeficiency virus replication, heat shock, atherosclerotic plaque, pathogenesis of Type I diabetes, and apoptosis, are presented.
Journal ArticleDOI
Interferons and bacterial lipopolysaccharide protect macrophages from productive infection by human immunodeficiency virus in vitro.
TL;DR: The data indicate that HIV replication in previously uninfected macrophages may be regulated by an inducible host cell mechanism and suggest an antiviral role for interferons in the therapy of HIV infection.
Journal ArticleDOI
The sickness behaviour and CNS inflammatory mediator profile induced by systemic challenge of mice with synthetic double-stranded RNA (poly I:C).
Colm Cunningham,Suzanne Campion,Suzanne Campion,Jessica L. Teeling,Jessica L. Teeling,Leigh M. Felton,Leigh M. Felton,V.H. Perry,V.H. Perry +8 more
TL;DR: Clear CNS effects of peripheral TLR3 stimulation are demonstrated and will be useful in studying aspects of the effects of systemic viral infection on brain function in both normal and pathological situations.
References
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Journal ArticleDOI
Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS
Robert C. Gallo,Syed Zaki Salahuddin,Mikulas Popovic,Gene M. Shearer,Mark H. Kaplan,Barton F. Haynes,Thomas J. Palker,Robert R. Redfield,James M. Oleske,Bijan Safai,Gilbert C. White,Paul Foster,Phillip D. Markham +12 more
TL;DR: Peripheral blood lymphocytes from patients with the acquired immunodeficiency syndrome (AIDS) or with signs or symptoms that frequently precede AIDS (pre-AIDS) were grown in vitro with added T-cell growth factor and assayed for the expression and release of human T-lymphotropic retroviruses (HTLV).
Journal ArticleDOI
Administration of 3'-azido-3'-deoxythymidine, an inhibitor of htlv-iii/lav replication, to patients with aids or aids-related complex
Robert Yarchoan,Kent J. Weinhold,H. Kim Lyerly,Edward P. Gelmann,Robert M. Blum,Gene M. Shearer,Hiroaki Mitsuya,Jerry M. Collins,Charles E. Myers,Raymond W. Klecker,Phillip D. Markham,David T. Durack,S. Nusinoff Lehrman,David W. Barry,Margaret A. Fischl,Robert C. Gallo,Dani P. Bolognesi,Samuel Broder +17 more
TL;DR: 4 dose regimens of 3'-azido-3'-deoxythymidine (AZT), a thymidine analogue with potent anti-viral activity against HTLV-III in vitro, were examined in 19 patients with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC).
Journal ArticleDOI
Platelet-derived growth factor and double-stranded ribonucleic acids stimulate expression of the same genes in 3T3 cells
TL;DR: It is shown that double-stranded ribonucleic acid is a potent inducer of the competence gene family, and these PDGF-inducible genes could conceivably function in a feedback loop to control 3T3 cell growth.
Journal ArticleDOI
Defective interfering particles with covalently linked [+/-]RNA induce interferon
TL;DR: Defective interfering particles of vesicular stomatitis virus which contain covalently linked complementary [+]message and [−]anti-message RNA as a single-stranded ribonucleoprotein complex within the particle, are extremely efficient inducers of interferon.
Journal ArticleDOI
Structural requirements of the rIn·rCn complex for Induction of human interferon☆
TL;DR: Two inducers may have a better therapeutic index than rIn·rCn itself; they are hydrolyzed by nucleases five- to eight-fold faster, and yet are nearly as active as interferon inducers.
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Administration of 3'-azido-3'-deoxythymidine, an inhibitor of htlv-iii/lav replication, to patients with aids or aids-related complex
Robert Yarchoan,Kent J. Weinhold,H. Kim Lyerly,Edward P. Gelmann,Robert M. Blum,Gene M. Shearer,Hiroaki Mitsuya,Jerry M. Collins,Charles E. Myers,Raymond W. Klecker,Phillip D. Markham,David T. Durack,S. Nusinoff Lehrman,David W. Barry,Margaret A. Fischl,Robert C. Gallo,Dani P. Bolognesi,Samuel Broder +17 more