Open Access
Comparative Effectiveness of Treatments To Prevent Fractures in Men and Women With Low Bone Density or Osteoporosis
Catherine H. MacLean,Alicia Alexander,Jason Carter,Susan Chen,Sheetal B Desai,Jennifer M. Grossman,Margaret Maglione,Maureen McMahon,Melissa McNamara,Walter Mojica,Sydne J Newberry,Veena K. Ranganath,Marika J. Suttorp,Martha Timmer,Carlo Tringale,Di Valentine,Annie Zhou +16 more
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TLDR
In this article, the authors compared the benefits in fracture reduction and the harms from adverse events (AE) among and within the various classes of treatment for low bone density for vertebral, non-vertebral, hip, and radial fractures.Abstract:
This Comparative Effectiveness Review (CER) compares the benefits in fracture reduction and the harms from adverse events (AE) among and within the various classes of treatment for low bone density. Our outcomes of interest for measuring benefits are vertebral, non-vertebral, hip, and radial fractures. The studies collect vertebral fracture outcomes in one of two ways. In some studies, all participants undergo radiography at pre-determined intervals. Other studies use clinical criteria, i.e. whether a fracture has been diagnosed by a clinician during the time interval. Trials that radiograph all participants will by nature detect more fractures. However the higher detection rate will apply to both treatment and placebo groups. Thus, the relative differences found should be similar that found in studies that use clinical criteria.read more
Citations
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Journal ArticleDOI
Calcium plus vitamin D supplementation and the risk of fractures.
Rebecca D. Jackson,Andrea Z. LaCroix,Margery Gass,Robert B. Wallace,John A Robbins,Cora E. Lewis,Tamsen Bassford,Shirley A.A. Beresford,Henry R. Black,Patricia L. Blanchette,Denise E. Bonds,Robert L. Brunner,Robert G. Brzyski,Bette J. Caan,Jane A. Cauley,Rowan T. Chlebowski,Steven R. Cummings,Iris A. Granek,Jennifer Hays,Gerardo Heiss,Susan L. Hendrix,Barbara V. Howard,Judith Hsia,F. Allan Hubbell,Karen C. Johnson,Howard L. Judd,Jane Morley Kotchen,Lewis H. Kuller,Robert Langer,Norman L. Lasser,Marian C. Limacher,Shari E. Ludlam,JoAnn E. Manson,Karen L. Margolis,Joan McGowan,Judith K. Ockene,Mary Jo O'Sullivan,Lawrence S. Phillips,Ross L. Prentice,Gloria E. Sarto,Marcia L. Stefanick,Linda Van Horn,Jean Wactawski-Wende,Evelyn P Whitlock,Garnet L. Anderson,Annlouise R. Assaf,David H. Barad +46 more
TL;DR: Among healthy postmenopausal women, calcium with vitamin D supplementation resulted in a small but significant improvement in hip bone density, did not significantly reduce hip fracture, and increased the risk of kidney stones.
Journal ArticleDOI
2010 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada: summary
Alexandra Papaioannou,Suzanne N Morin,Angela M. Cheung,Stephanie A. Atkinson,Jacques P. Brown,Sidney Feldman,David A. Hanley,Anthony B. Hodsman,Sophie A. Jamal,Stephanie M. Kaiser,Brent Kvern,Kerry Siminoski,William D. Leslie +12 more
TL;DR: There has been a paradigm shift in the prevention and treatment of osteoporosis and fractures, and the focus now is on preventing fragility fractures and their negative effects.
Journal ArticleDOI
Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards
Samuel D Vasikaran,Samuel D Vasikaran,Richard Eastell,Olivier Bruyère,A. J. Foldes,P. Garnero,Andrea Griesmacher,Michael R. McClung,Howard A. Morris,Stuart L. Silverman,Tommaso Trenti,D. A. Wahl,Cyrus Cooper,Cyrus Cooper,John A. Kanis +14 more
TL;DR: BTM hold promise in fracture risk prediction and for monitoring treatment and Uncertainties over their clinical use can be in part resolved by adopting international reference standards.
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The Patient Who Falls: “It’s Always a Trade-off”
Mary E. Tinetti,Chandrika Kumar +1 more
TL;DR: Using the case of an older man who has experienced multiple falls and a hip fracture, the consequences and etiology of falls are addressed; the evidence on predisposing factors and effective interventions are summarized; and how to translate this evidence into patient care is discussed.
Journal ArticleDOI
Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody.
TL;DR: Single doses of AMG 785 generally were well tolerated, and the data support further clinical investigation of sclerostin inhibition as a potential therapeutic strategy for conditions that could benefit from increased bone formation.
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