Journal ArticleDOI
Comparison of Macrophage Phenotype Between Decidua Basalis and Decidua Parietalis by Flow Cytometry
U. Repnik,Tamara Tilburgs,Dave L. Roelen,B.J. van der Mast,H. H. H. Kanhai,S.A. Scherjon,Frans H.J. Claas +6 more
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TLDR
The expressions of CD105, DC-SIGN and MMR were the strongest in decidua basalis of mid pregnancy and indicate the importance of decidual macrophages in tissue homeostasis at the uteroplacental interface.About:
This article is published in Placenta.The article was published on 2008-05-01. It has received 79 citations till now. The article focuses on the topics: Decidua Basalis & Decidua Parietalis.read more
Citations
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Journal ArticleDOI
The unique immunological and microbial aspects of pregnancy
TL;DR: Recent evidence that supports the idea that immunological responses at the receptive maternal–fetal interface are not simply suppressed but are instead highly dynamic is discussed.
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Macrophages at the Fetal–Maternal Interface Express Markers of Alternative Activation and Are Induced by M-CSF and IL-10
TL;DR: Results consistently point to a central role for M-CSF and in particular IL-10 in the shaping of decidual Mϕ with regulatory properties, which may play an important role in supporting the homeostatic and tolerant immune milieu required for a successful pregnancy.
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Immune cells in the placental bed.
TL;DR: The next 25 years may provide more answers to the role of the endometrial leukocytes in normal pregnancy, so that further advances can be made in investigation of their role, if any, in pregnancy pathology.
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Two Unique Human Decidual Macrophage Populations
TL;DR: Two distinct subsets of CD14+ decidual macrophages (dMɸs) are found to be present in first-trimester decidua, and each secrete both proinflammatory and anti-inflammatory cytokines that may contribute to the balance that establishes fetal–maternal tolerance.
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The immunomodulatory roles of macrophages at the maternal-fetal interface
TL;DR: Decidual macrophages exert an immunosuppressive phenotype characterized by abundant production of interleukin (IL)-10 and indoleamine 2,3-dioxygenase activity that favors maternal immune tolerance to semiallogenic fetus.
References
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Pattern recognition receptors: doubling up for the innate immune response.
TL;DR: Antigen presenting cells (macrophages and dendritic cells) express pattern recognition molecules that are thought to recognize foreign ligands during early phases of the immune response, suggesting that they play a dual role in normal tissue function and host defense.
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Endovascular Trophoblast Invasion: Implications for the Pathogenesis of Intrauterine Growth Retardation and Preeclampsia
TL;DR: The reviewed data suggest that endovascular trophoblast invasion involves a side route of interstitial invasion, which is associated with maintenance of high uteroplacental vascular resistance and intrauterine growth restriction (IUGR) and preeclampsia.
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Mycobacteria Target DC-SIGN to Suppress Dendritic Cell Function
Teunis B.H. Geijtenbeek,Sandra J. van Vliet,Estella A Koppel,Marta Sanchez-Hernandez,Christine M.J.E. Vandenbroucke-Grauls,Ben J. Appelmelk,Yvette van Kooyk +6 more
TL;DR: It is demonstrated that the DC-specific C-type lectin DC-SIGN is an important receptor on DCs that captures and internalizes intact Mycobacterium bovis bacillus Calmette-Guérin (BCG) through the mycobacterial cell wall component ManLAM.
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Immunology of placentation in eutherian mammals.
Ashley Moffett,Charlie Loke +1 more
TL;DR: The traditional way to study the immunology of pregnancy follows the classical transplantation model, which views the fetus as an allograft, but a more recent approach focuses on the unique, local uterine immune response to the implanting placenta.
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Scavenger receptors in innate immunity.
TL;DR: Scavenger receptors are expressed by myeloid cells (macrophages and dendritic cells) and certain endothelial cells and are involved in lipid metabolism and bind modified low-density lipoproteins.