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Comparison of mucosal adhesion and species identification of bifidobacteria isolated from healthy and allergic infants

TLDR
Dietary supplementation of bifidobacteria typical for healthy infants, may be beneficial in the treatment of allergic disorders and suggests a correlation between allergic disease and the composition of the intestinal bifIDobacteria flora which has reduced adhesive abilities to the intestinal mucus.
Abstract
Fifty bifidobacteria strains were isolated from fecal samples of allergic and age matched healthy infants. Allergic infants were found to have an adult type Bifidobacterium flora with high levels of Bifidobacterium adolescentis. Healthy infants had a typical infant Bifidobacterium flora with high levels of Bifidobacterium bifidum. These isolates were tested for their adhesive properties to human intestinal mucus. The adhesion of the fecal bifidobacteria from healthy infants was significantly higher (P<0.0001) than for allergic infants. This suggests a correlation between allergic disease and the composition of the intestinal bifidobacteria flora which has reduced adhesive abilities to the intestinal mucus. Therefore, dietary supplementation of bifidobacteria typical for healthy infants, may be beneficial in the treatment of allergic disorders.

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Antagonistic activities of lactobacilli and bifidobacteria against microbial pathogens

TL;DR: There is increasing evidence that lactobacilli and bifidobacteria, which inhabit the gastrointestinal microbiota, develop antimicrobial activities that participate in the host's gastrointestinal system of defence.
Journal ArticleDOI

Bacterial metabolism and health-related effects of galacto-oligosaccharides and other prebiotics

TL;DR: Inulin-derived oligosaccharides and GOS are mildly laxative, but can result in flatulence and osmotic diarrhoea if taken in large amounts.
Journal ArticleDOI

Drugs in Pregnancy

TL;DR: For example, this article found that most drugs that appear in the Physicians' Desk Reference and similar sources contain statements such as, “Use in pregnancy is not recommended unless the potential benefits justify the potential risks to the fetus.
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The role of the intestinal microbiota in the development of atopic disorders

TL;DR: The microbiota hypothesis in atopic diseases is promising and deserves further attention, but to gain more insight into the role of the gut microbiota in the etiology of atopy, large‐scale prospective birth cohort studies using molecular methods to study the Gut microbiota are needed.
Journal ArticleDOI

Probiotics: potential pharmaceutical applications.

TL;DR: The present review encompasses information regarding the probiotics and their proposed uses, including the concepts of prebiotics and synbiotics, the application of genetic engineering to produce newer probiotics, and questions regarding the reliability, utility and the safety of these products.
References
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Journal ArticleDOI

Functional food science and gastrointestinal physiology and function

TL;DR: The develop-ment of functional foods for the gut is in its infancy and will be successful only if more fundamental research is done on digestive physiology, the gut microflora, immune system and mucosal function.
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The intestinal microflora in allergic Estonian and Swedish 2-year-old children.

TL;DR: It has been suggested that a reduced microbial stimulation during infancy and early childhood would result in a slower postnatal maturation of the immune system and development of an optimal balance between TH1‐ and TH2‐like immunity.
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Fecal Microflora in Healthy Infants Born by Different Methods of Delivery: Permanent Changes in Intestinal Flora After Cesarean Delivery

TL;DR: It is shown for the first time that the primary gut flora in infants born by cesarean delivery may be disturbed for up to 6 months after the birth, and even longer follow-up is needed to establish how long-lasting these alterations of thePrimary gut flora can be.
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The Bifidogenic Nature of Chicory Inulin and Its Hydrolysis Products

TL;DR: In vitro fermentation of inulin revealed that molecules with a chain length (degree of polymerization or DP) > 10 are fermented on average half as quickly as molecule with a DP < 10, and all beta(2-1)fructans are bifidogenic and classified as biobiotics.
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The Intestinal Microflora of Infants: Composition of Fecal Flora in Breast-Fed and Bottle-Fed Infants

TL;DR: The fecal flora of 35 breast‐fed and 35 bottle‐fed babies was determined and the organism that showed the highest number and the highest frequency of occurrence in both groups was Bifidobacterium breve.
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