Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: The AMBITION study
Graeme Jones,Anthony Sebba,Jieruo Gu,Mitchell B. Lowenstein,Armando Calvo,Juan J. Gomez-Reino,Daniel Siri,Matija Tomšič,Emma Alecock,Thasia G. Woodworth,Mark C. Genovese +10 more
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TLDR
Tocilizumab monotherapy is better than methotrexate monotherapy, with rapid improvement in RA signs and symptoms, and a favourable benefit–risk, in patients for whom treatment with methotRexate or biological agents has not previously failed.Abstract:
Background: The anti-interleukin (IL) 6 receptor antibody tocilizumab inhibits signalling of IL6, a key cytokine in rheumatoid arthritis (RA) pathogenesis. Objective: To evaluate through the AMBITION study the efficacy and safety of tocilizumab monotherapy versus methotrexate in patients with active RA for whom previous treatment with methotrexate/biological agents had not failed. Methods: This 24-week, double-blind, double-dummy, parallel-group study, randomised 673 patients to either tocilizumab 8 mg/kg every 4 weeks, or methotrexate, starting at 7.5 mg/week and titrated to 20 mg/week within 8 weeks, or placebo for 8 weeks followed by tocilizumab 8 mg/kg. The primary end point was the proportion of patients achieving American College of Rheumatology (ACR) 20 response at week 24. Results: The intention-to-treat analysis demonstrated that tocilizumab was better than methotrexate treatment with a higher ACR20 response (69.9 vs 52.5%; p 3×– Conclusion: Tocilizumab monotherapy is better than methotrexate monotherapy, with rapid improvement in RA signs and symptoms, and a favourable benefit–risk, in patients for whom treatment with methotrexate or biological agents has not previously failed. Trial registration number: NCT00109408read more
Citations
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Multiplex analysis of laboratory biomarkers in assessing effectiveness of tocilizumab in treatment of rheumatoid arthritis
TL;DR: In this article, the authors evaluated the effectiveness of TCZumab (TCZ) in RA using multiplex cytokine analysis and found that the most associated factors with the effectiveness were: MMP-3 (AUC 0.85; CI: 0.7-1.0), anti-CCP (0.7), and VEGF(0.5).
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Comparison of treatment of severe rheumatoid arthritis patients with biological agents and JAK-STAT inhibitors. An observational study
TL;DR: The results of the present observational study indicated that treatment with JAK inhibitors is very promising, and these drugs are not inferior in effectiveness to bDMARDs.
Новые направления фармакотерапии ревматических заболеваний - ингибиция интерлейкина 6 и интерлейкина 17
E. L. Nasonov,V. A. Nasonova +1 more
TL;DR: In this paper, the authors propose a method to improve the quality of the data collected by the system. But, their method is not suitable for large-scale data sets, such as large data sets with large numbers of users.
Journal ArticleDOI
Polyarthrite rhumatoïde traitée par tocilizumab chez deux patients souffrant d’hépatopathie chronique compliquée d’hypertension portale
TL;DR: Les perfusions de tocilizumab a la posologie de 4 mg/kg, en monotherapie, ont permis d’obtenir un sevrage en cortisoniques, une remission a la fois clinique et structurale avec une tolerance hepatique satisfaisante a 10 et 18 mois.
References
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TL;DR: Subcutaneous [corrected] etanercept acted more rapidly to decrease symptoms and slow joint damage in patients with early active rheumatoid arthritis.
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