Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: The AMBITION study
Graeme Jones,Anthony Sebba,Jieruo Gu,Mitchell B. Lowenstein,Armando Calvo,Juan J. Gomez-Reino,Daniel Siri,Matija Tomšič,Emma Alecock,Thasia G. Woodworth,Mark C. Genovese +10 more
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TLDR
Tocilizumab monotherapy is better than methotrexate monotherapy, with rapid improvement in RA signs and symptoms, and a favourable benefit–risk, in patients for whom treatment with methotRexate or biological agents has not previously failed.Abstract:
Background: The anti-interleukin (IL) 6 receptor antibody tocilizumab inhibits signalling of IL6, a key cytokine in rheumatoid arthritis (RA) pathogenesis. Objective: To evaluate through the AMBITION study the efficacy and safety of tocilizumab monotherapy versus methotrexate in patients with active RA for whom previous treatment with methotrexate/biological agents had not failed. Methods: This 24-week, double-blind, double-dummy, parallel-group study, randomised 673 patients to either tocilizumab 8 mg/kg every 4 weeks, or methotrexate, starting at 7.5 mg/week and titrated to 20 mg/week within 8 weeks, or placebo for 8 weeks followed by tocilizumab 8 mg/kg. The primary end point was the proportion of patients achieving American College of Rheumatology (ACR) 20 response at week 24. Results: The intention-to-treat analysis demonstrated that tocilizumab was better than methotrexate treatment with a higher ACR20 response (69.9 vs 52.5%; p 3×– Conclusion: Tocilizumab monotherapy is better than methotrexate monotherapy, with rapid improvement in RA signs and symptoms, and a favourable benefit–risk, in patients for whom treatment with methotrexate or biological agents has not previously failed. Trial registration number: NCT00109408read more
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Effect of interleukin-6 receptor inhibitor, tocilizumab, in preventing joint destruction in patients with rheumatoid arthritis showing inadequate response to TNF inhibitors
Yoshiya Tanaka,Tsutomu Takeuchi,Koichi Amano,Kazuyoshi Saito,Kentaro Hanami,Masao Nawata,Shunsuke Fukuyo,Hideto Kameda,Yuko Kaneko,Takahiko Kurasawa,Hayato Nagasawa,Daisuke Hoshi,Eri Sato,Hisashi Yamanaka +13 more
TL;DR: TCZ was a good treatment option for improving signs and symptoms and inhibiting progression of joint damage in patients with clinical and structural TNF-IR by assessing X-rays.
Journal ArticleDOI
Monitoring of Epstein-Barr virus (EBV)/cytomegalovirus (CMV)/varicella-zoster virus (VZV) load in patients receiving tocilizumab for rheumatoid arthritis
Cindy Mourgues,Cécile Henquell,Zuzana Tatar,Bruno Pereira,Cinthya Nourisson,Anne Tournadre,Martin Soubrier,Marion Couderc +7 more
TL;DR: TCZ does not seem to increase the VL of EBV, CMV or VZV in patients with rheumatoid arthritis and studies involving larger patient populations are necessary.
Journal ArticleDOI
Comparing Effects of Biologic Agents in Treating Patients with Rheumatoid Arthritis: A Multiple Treatment Comparison Regression Analysis.
TL;DR: A multiple treatment comparison regression analysis found the drug effect to be dependent on dose level, but not on disease duration, and the impact of a high versus low dose level was the same for all drugs.
Journal ArticleDOI
Drug retention of 7 biologics and tofacitinib in biologics-naïve and biologics-switched patients with rheumatoid arthritis -The ANSWER cohort study-
Kosuke Ebina,Toru Hirano,Yuichi Maeda,Wataru Yamamoto,Motomu Hashimoto,Koichi Murata,Tohru Takeuchi,Hideyuki Shiba,Yonsu Son,Hideki Amuro,Akira Onishi,K. Akashi,Ryota Hara,Masaki Katayama,Keiichi Yamamoto,Atsushi Kumanogoh,Makoto Hirao +16 more
TL;DR: Remarkable differences were observed in drug retention of 7 b DMARDs and TOF between bDMARDs-naïve and bDMards-switched patients with rheumatoid arthritis (RA).
Journal ArticleDOI
A randomized, double-blind, parallel-group, phase III study of shortening the dosing interval of subcutaneous tocilizumab monotherapy in patients with rheumatoid arthritis and an inadequate response to subcutaneous tocilizumab every other week: Results of the 12-week double-blind period.
TL;DR: In patients with inadequate response to TCZ-SC q2w, shortening the dosing interval to qw improved efficacy with acceptable tolerability and Occurrence of infection for both TCZ q 2w and qw is important and needs careful attention.
References
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Cytokine Pathways and Joint Inflammation in Rheumatoid Arthritis
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TL;DR: Subcutaneous [corrected] etanercept acted more rapidly to decrease symptoms and slow joint damage in patients with early active rheumatoid arthritis.
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