Complement C3 is a risk factor for the development of diabetes: a population-based cohort study.
TLDR
It is concluded that the risk of developing diabetes is related to levels of complement C3, and only C3 was significantly associated with diabetes development after further adjustments for potential confounders, including BMI, insulin, and other inflammatory markers.Abstract:
Cross-sectional studies have reported strong correlations between plasma levels of complement C3, insulin, and glucose. This prospective study explored whether elevated levels of C3, C4, and other inflammation-sensitive plasma proteins (ISPs; fibrinogen, orosomucoid, alpha1-antitrypsin, haptoglobin, and ceruloplasmin) are associated with the development of diabetes. Plasma proteins were measured in 2,815 nondiabetic healthy men, age 38-50 years, who were reexamined after a mean follow-up of 6.1 years. Diabetes development (n = 123) was studied in relation to baseline levels of plasma proteins. After adjusting for age, screening year, and glucose at baseline, the odds ratio (95% CI) for developing diabetes was 1.00, 2.4 (1.1-5.3), 2.9 (1.4-6.0), and 5.6 (2.8-10.9), respectively, for men with C3 in the 1st, 2nd, 3rd, and 4th quartiles (trend: P < 0.00001). Fibrinogen, haptoglobin, C4, and the number of elevated ISPs were also related to future diabetes in this model. Only C3 was significantly associated with diabetes development after further adjustments for potential confounders, including BMI, insulin, and other inflammatory markers. We concluded that the risk of developing diabetes is related to levels of complement C3.read more
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Complement activation in polycystic ovary syndrome occurs in the postprandial and fasted state and is influenced by obesity and insulin sensitivity.
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Lifestyle changes followed by bariatric surgery lower inflammatory markers and the cardiovascular risk factors C3 and C4.
Torunn Kristin Nestvold,Erik Waage Nielsen,Judith K Ludviksen,Hilde Fure,Anne Landsem,Knut Tore Lappegård +5 more
TL;DR: The effect of bariatric surgery on markers of inflammation, coagulation and glucose metabolism, including high-sensitivity C-reactive protein, tumor necrosis factor-α, interferon-γ, i...
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Associations of ambient fine particulate matter and its constituents with serum complement C3 in a panel study of older adults in China.
TL;DR: The results revealed that short-term exposure to PM2.5 and its constituents could result in a significant increase in serum level of complement C3, and suggested a possible involvement of complementC3 in the effect of PM 2.5 on inflammatory reaction.
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