Complement C3 is a risk factor for the development of diabetes: a population-based cohort study.
TLDR
It is concluded that the risk of developing diabetes is related to levels of complement C3, and only C3 was significantly associated with diabetes development after further adjustments for potential confounders, including BMI, insulin, and other inflammatory markers.Abstract:
Cross-sectional studies have reported strong correlations between plasma levels of complement C3, insulin, and glucose. This prospective study explored whether elevated levels of C3, C4, and other inflammation-sensitive plasma proteins (ISPs; fibrinogen, orosomucoid, alpha1-antitrypsin, haptoglobin, and ceruloplasmin) are associated with the development of diabetes. Plasma proteins were measured in 2,815 nondiabetic healthy men, age 38-50 years, who were reexamined after a mean follow-up of 6.1 years. Diabetes development (n = 123) was studied in relation to baseline levels of plasma proteins. After adjusting for age, screening year, and glucose at baseline, the odds ratio (95% CI) for developing diabetes was 1.00, 2.4 (1.1-5.3), 2.9 (1.4-6.0), and 5.6 (2.8-10.9), respectively, for men with C3 in the 1st, 2nd, 3rd, and 4th quartiles (trend: P < 0.00001). Fibrinogen, haptoglobin, C4, and the number of elevated ISPs were also related to future diabetes in this model. Only C3 was significantly associated with diabetes development after further adjustments for potential confounders, including BMI, insulin, and other inflammatory markers. We concluded that the risk of developing diabetes is related to levels of complement C3.read more
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Serum complement C3 and islet β-cell function in patients with type 2 diabetes: A 4.6-year prospective follow-up study
Jian-bin Su,Yun-Yu Wu,Feng Xu,Xing Wang,Hong-li Cai,Li-hua Zhao,Xiu-lin Zhang,Tong Chen,Hai-yan Huang,Xue-qin Wang +9 more
TL;DR: Serum complement C3 levels were positively correlated with baseline natural logarithm of AUC cp (lnAUC cp), and its changes were also independently associated with changes in islet β-cell function over time in patients with T2D.
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Association of thyroid hormones with resting energy expenditure and complement C3 in normal weight high body fat women
Maryam Karkhaneh,Mostafa Qorbani,Asal Ataie-Jafari,Mohamad Reza Mohajeri-Tehrani,Hamid Asayesh,Saeed Hosseini +5 more
TL;DR: An increase in body fat even in the presence of a normal body weight can be accompanied by the changes in thyroid function and inflammatory markers such as complement C3.
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Serum IgG2 levels are specifically associated with whole-body insulin-mediated glucose disposal in non-diabetic offspring of type 2 diabetic individuals: a cross-sectional study
Teresa Vanessa Fiorentino,Elena Succurro,Franco Arturi,Aida Giancotti,Cinzia Peronace,Angela Quirino,Franz Sesti,Francesco Andreozzi,Marta Letizia Hribal,Francesco Perticone,Alfredo Focà,Giorgio Sesti +11 more
TL;DR: The independent association between higher levels of IgG2 and decreased whole-body insulin sensitivity in non-diabetic individuals is confirmed in humans, thus confirming in humans the animal-based evidence indicating the pathogenic role of Igg2 in insulin resistance.
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Protective role of complement C3 against cytokine-mediated beta cell apoptosis
R. S. Dos Santos,Laura Marroquí,Fabio Arturo Grieco,Lorella Marselli,S. R. Henz,Piero Marchetti,Rasmus Wernersson,DL Eizirik +7 more
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Serum proteome assessment in nonalcoholic fatty liver disease in children: a preliminary study.
Paweł Małecki,Joanna Tracz,Magdalena Łuczak,Magdalena Figlerowicz,Katarzyna Mazur-Melewska,Wojciech Służewski,Anna Mania +6 more
TL;DR: The plasma protein profile is significantly altered in nonalcoholic liver disease in children and may prove to be a valuable source of biomarkers to evaluate the extent of liver disease.
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