Complement C3 is a risk factor for the development of diabetes: a population-based cohort study.
TLDR
It is concluded that the risk of developing diabetes is related to levels of complement C3, and only C3 was significantly associated with diabetes development after further adjustments for potential confounders, including BMI, insulin, and other inflammatory markers.Abstract:
Cross-sectional studies have reported strong correlations between plasma levels of complement C3, insulin, and glucose. This prospective study explored whether elevated levels of C3, C4, and other inflammation-sensitive plasma proteins (ISPs; fibrinogen, orosomucoid, alpha1-antitrypsin, haptoglobin, and ceruloplasmin) are associated with the development of diabetes. Plasma proteins were measured in 2,815 nondiabetic healthy men, age 38-50 years, who were reexamined after a mean follow-up of 6.1 years. Diabetes development (n = 123) was studied in relation to baseline levels of plasma proteins. After adjusting for age, screening year, and glucose at baseline, the odds ratio (95% CI) for developing diabetes was 1.00, 2.4 (1.1-5.3), 2.9 (1.4-6.0), and 5.6 (2.8-10.9), respectively, for men with C3 in the 1st, 2nd, 3rd, and 4th quartiles (trend: P < 0.00001). Fibrinogen, haptoglobin, C4, and the number of elevated ISPs were also related to future diabetes in this model. Only C3 was significantly associated with diabetes development after further adjustments for potential confounders, including BMI, insulin, and other inflammatory markers. We concluded that the risk of developing diabetes is related to levels of complement C3.read more
Citations
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Is plasma C3 and C4 levels useful in young cerebral ischemic stroke patients? Associations with prognosis at 3 months
Bin ZhangNing,YangCong Gao +1 more
TL;DR: Wang et al. as mentioned in this paper conducted a study to establish the significance of admission C3 and C4 levels as a possible predictor of 3 months prognosis in young patients with acute ischemic stroke.
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Sigma-1 Receptor as a Protective Factor for Diabetes-Associated Cognitive Dysfunction via Regulating Astrocytic Endoplasmic Reticulum-Mitochondrion Contact and Endoplasmic Reticulum Stress
Mengyu Du,Tao Jiang,Shuxuan He,Bo Cheng,Xin Zhang,Liya Li,Lan Yang,Weiman Gao,Yansong Li,Qiang Wang +9 more
TL;DR: In this article , the role of the sigma-1 receptor (Sig-1R) and its underlying mechanism in cognitive dysfunction in patients with Type 1 diabetes mellitus was investigated.
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Association of complement C3 with incident type 2 diabetes and the mediating role of BMI: A 10-year follow-up study.
Jing Jiang,Hao Wang,Kang Liu,Shiqi He,Zhaoyang Li,Yu Yuan,Kuai Yu,Pinpin Long,Jiyang Wang,Tingyue Diao,Xiaomin Zhang,Meian He,Huan Guo,Tangchun Wu +13 more
TL;DR: It is revealed that C3 could be an early biomarker for incident T2DM, and that BMI might play a potential mediating role in the C3-T2DM associations, which provided clues for the pathogenesis of diabetes.
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The relevance of serum complement C3 with fasting blood glucose levels in obese type 2 diabetics
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