Complement C3 is a risk factor for the development of diabetes: a population-based cohort study.
TLDR
It is concluded that the risk of developing diabetes is related to levels of complement C3, and only C3 was significantly associated with diabetes development after further adjustments for potential confounders, including BMI, insulin, and other inflammatory markers.Abstract:
Cross-sectional studies have reported strong correlations between plasma levels of complement C3, insulin, and glucose. This prospective study explored whether elevated levels of C3, C4, and other inflammation-sensitive plasma proteins (ISPs; fibrinogen, orosomucoid, alpha1-antitrypsin, haptoglobin, and ceruloplasmin) are associated with the development of diabetes. Plasma proteins were measured in 2,815 nondiabetic healthy men, age 38-50 years, who were reexamined after a mean follow-up of 6.1 years. Diabetes development (n = 123) was studied in relation to baseline levels of plasma proteins. After adjusting for age, screening year, and glucose at baseline, the odds ratio (95% CI) for developing diabetes was 1.00, 2.4 (1.1-5.3), 2.9 (1.4-6.0), and 5.6 (2.8-10.9), respectively, for men with C3 in the 1st, 2nd, 3rd, and 4th quartiles (trend: P < 0.00001). Fibrinogen, haptoglobin, C4, and the number of elevated ISPs were also related to future diabetes in this model. Only C3 was significantly associated with diabetes development after further adjustments for potential confounders, including BMI, insulin, and other inflammatory markers. We concluded that the risk of developing diabetes is related to levels of complement C3.read more
Citations
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The vulnerable blood. Coagulation and clot structure in diabetes mellitus.
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Protective Role of Complement C3 Against Cytokine-Mediated β-Cell Apoptosis
Reinaldo Sousa Dos Santos,Laura Marroquí,Fabio Arturo Grieco,Lorella Marselli,Mara Suleiman,Stefan S.R. Henz,Piero Marchetti,Rasmus Wernersson,Decio L. Eizirik +8 more
TL;DR: RNA sequencing and protein-protein interaction analyses of human islets exposed to proinflammatory cytokines suggest that locally produced C3 is an important prosurvival mechanism in pancreatic β-cells under a proinflammatory assault.
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Can complement factors 5 and 8 and transthyretin be used as biomarkers for MODY 1 (HNF4A-MODY) and MODY 3 (HNF1A-MODY)?
TL;DR: This work set out to determine whether serum concentrations of C5, C8 and TTR can be used as biomarkers for patients with HNF4A‐MODY and HNF1A-MODY.
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C3aR and C5aR1 act as key regulators of human and mouse β-cell function
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