Complement C3 is a risk factor for the development of diabetes: a population-based cohort study.
TLDR
It is concluded that the risk of developing diabetes is related to levels of complement C3, and only C3 was significantly associated with diabetes development after further adjustments for potential confounders, including BMI, insulin, and other inflammatory markers.Abstract:
Cross-sectional studies have reported strong correlations between plasma levels of complement C3, insulin, and glucose. This prospective study explored whether elevated levels of C3, C4, and other inflammation-sensitive plasma proteins (ISPs; fibrinogen, orosomucoid, alpha1-antitrypsin, haptoglobin, and ceruloplasmin) are associated with the development of diabetes. Plasma proteins were measured in 2,815 nondiabetic healthy men, age 38-50 years, who were reexamined after a mean follow-up of 6.1 years. Diabetes development (n = 123) was studied in relation to baseline levels of plasma proteins. After adjusting for age, screening year, and glucose at baseline, the odds ratio (95% CI) for developing diabetes was 1.00, 2.4 (1.1-5.3), 2.9 (1.4-6.0), and 5.6 (2.8-10.9), respectively, for men with C3 in the 1st, 2nd, 3rd, and 4th quartiles (trend: P < 0.00001). Fibrinogen, haptoglobin, C4, and the number of elevated ISPs were also related to future diabetes in this model. Only C3 was significantly associated with diabetes development after further adjustments for potential confounders, including BMI, insulin, and other inflammatory markers. We concluded that the risk of developing diabetes is related to levels of complement C3.read more
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Effect of weight loss on C3 and C4 components of complement in obese patients.
Antonio Hernández-Mijares,Celia Bañuls,Lorena Bellod,Ana Jover,Eva Solá,Carlos Morillas,Victor M. Victor,Victor M. Victor,Milagros Rocha,Milagros Rocha +9 more
TL;DR: In this article, a longitudinal intervention study based on a 6-week very low-calorie diet (VLCD), a liquid formula of 603kcal/day, was conducted to evaluate the effects of weight loss on lipid and hydrocarbonated metabolism parameters and on the levels of C3 and C4 components of complement in obese patients.
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Screening for potential serum-based proteomic biomarkers for human type 2 diabetes mellitus using MALDI-TOF MS.
Qiutao Meng,Siqi Ge,Siqi Ge,Wenhua Yan,Ruisheng Li,Jingtao Dou,Haibing Wang,Baoan Wang,Qingwei Ma,Yong Zhou,Manshu Song,Xinwei Yu,Xinwei Yu,Hao Wang,Xinghua Yang,Fen Liu,Mohamed Ali Alzain,Yuxiang Yan,Ling Zhang,Lijuan Wu,Feifei Zhao,Yan He,Xiuhua Guo,Feng Chen,Weizhuo Xu,Monique Garcia,Desmond Dev Menon,Youxin Wang,Yiming Mu,Wei Wang,Wei Wang +30 more
TL;DR: Type 2 diabetes mellitus is a complex, pandemic disease contributing towards the global burden of health issues and there are no simple clinical tests for the early detection of T2DM.
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Peripheral complement proteins in schizophrenia: A systematic review and meta-analysis of serological studies.
TL;DR: Serological studies provide mixed evidence regarding dysregulation of the complement system in schizophrenia and larger studies of a longitudinal nature, focusing on early phenotypes, could provide further insights regarding the potential role of the complementary system in psychotic disorders.
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Rosiglitazone decreases postprandial production of acylation stimulating protein in type 2 diabetics
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Adipose tissue complement factor B promotes adipocyte maturation.
Hiroaki Matsunaga,Misaki Iwashita,Takanori Shinjo,Akiko Yamashita,Mitsudai Tsuruta,Shoichiro Nagasaka,Ataru Taniguchi,Mitsuo Fukushima,Naoya Watanabe,Fusanori Nishimura +9 more
TL;DR: CfB plays a crucial role in late-phase of adipocyte differentiation and subsequent lipid droplet formation in adipocytes and in the subcutaneous adipose tissue.
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