Complement C3 is a risk factor for the development of diabetes: a population-based cohort study.
TLDR
It is concluded that the risk of developing diabetes is related to levels of complement C3, and only C3 was significantly associated with diabetes development after further adjustments for potential confounders, including BMI, insulin, and other inflammatory markers.Abstract:
Cross-sectional studies have reported strong correlations between plasma levels of complement C3, insulin, and glucose. This prospective study explored whether elevated levels of C3, C4, and other inflammation-sensitive plasma proteins (ISPs; fibrinogen, orosomucoid, alpha1-antitrypsin, haptoglobin, and ceruloplasmin) are associated with the development of diabetes. Plasma proteins were measured in 2,815 nondiabetic healthy men, age 38-50 years, who were reexamined after a mean follow-up of 6.1 years. Diabetes development (n = 123) was studied in relation to baseline levels of plasma proteins. After adjusting for age, screening year, and glucose at baseline, the odds ratio (95% CI) for developing diabetes was 1.00, 2.4 (1.1-5.3), 2.9 (1.4-6.0), and 5.6 (2.8-10.9), respectively, for men with C3 in the 1st, 2nd, 3rd, and 4th quartiles (trend: P < 0.00001). Fibrinogen, haptoglobin, C4, and the number of elevated ISPs were also related to future diabetes in this model. Only C3 was significantly associated with diabetes development after further adjustments for potential confounders, including BMI, insulin, and other inflammatory markers. We concluded that the risk of developing diabetes is related to levels of complement C3.read more
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Complement C3 as a marker of cardiometabolic risk in psoriasis.
Tiago Torres,Nuno Bettencourt,Denisa Mendonça,Carlos Vasconcelos,Berta Martins da Silva,Manuela Selores +5 more
TL;DR: Within psoriasis patients, C3 levels were independently associated with abdominal visceral fat, insulin resistance, metabolic syndrome and oxidized LDL-cholesterol, while C-reactive protein did not, showing that C3 may be a better marker of cardiometabolic risk than C- reactive protein.
Journal ArticleDOI
New insights into complement C3 and inflammation in hypertension.
Sunil K. Nadar,Gregory Y.H. Lip +1 more
TL;DR: Inflammation may still have a role as a ‘bridge’ connecting hypertension and athero-sclerotic vascular disease and gaps still remain in understanding of the precise pathophysiological mechanism on how various risk factors such ashypertension, hypercholesterolaemia and diabetes lead to the development of atherosclerosis.
Journal ArticleDOI
Triacylglycerols and body fat mass are possible independent predictors of C3 in apparently healthy young Brazilian adults.
TL;DR: An independent role of triacylglycerols, a component of the metabolic syndrome, and body fat mass as possible predictors of C3 concentrations is demonstrated, demonstrating that C3 can be used as an early marker for metabolic syndrome manifestations.
Journal ArticleDOI
Elevated serum complement C3 levels are associated with prehypertension in an adult population.
Xue Bao,Ge Meng,Qing Zhang,Li Liu,Hongmei Wu,Huanmin Du,Hongbin Shi,Yang Xia,Xiaoyan Guo,Xing Liu,Peipei Han,Renwei Dong,Xiuyang Wang,Chunlei Li,Qian Su,Yeqing Gu,Liyun Fang,Fei Yu,Huijun Yang,Li Kang,Yixuan Ma,Bin Yu,Xinyu Ma,Shaomei Sun,Xing Wang,Ming Zhou,Qiyu Jia,Qi Guo,Kun Song,Guolin Wang,Guowei Huang,Kaijun Niu,Kaijun Niu +32 more
TL;DR: The findings suggested that elevated serum C3 levels are associated with prehypertension, and reducing inflammation may be a potential therapeutic strategy for pre Hypertension and hypertension that is worthy of further studies and discussion.
Journal ArticleDOI
Circulating HER2/ErbB2 Levels Are Associated With Increased Incidence of Diabetes: A Population-Based Cohort Study
Iram Faqir Muhammad,Yan Borné,Xue Bao,Xue Bao,Olle Melander,Marju Orho-Melander,Peter M. Nilsson,Jan Nilsson,Gunnar Engström +8 more
TL;DR: Elevated levels of ErbB2 are associated with increased incidence of diabetes and was significantly and positively associated with glucose, insulin, and HbA1c after being adjusted for potential confounding factors.
References
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Journal ArticleDOI
Homeostasis model assessment : insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
TL;DR: The correlation of the model's estimates with patient data accords with the hypothesis that basal glucose and insulin interactions are largely determined by a simple feed back loop.
Journal ArticleDOI
C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus
TL;DR: Elevated levels of CRP and IL-6 predict the development of type 2 DM, and data support a possible role for inflammation in diabetogenesis.
Journal ArticleDOI
C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction A Potential Role for Cytokines Originating From Adipose Tissue?
TL;DR: The data suggest that adipose tissue is an important determinant of a low level, chronic inflammatory state as reflected by levels of interleukin-6, tumor necrosis factor-alpha, and C-reactive protein, and that infection with H pylori, C pneumoniae, and cytomegalovirus is not.
Journal ArticleDOI
Elevated Levels of Acute-Phase Proteins and Plasminogen Activator Inhibitor-1 Predict the Development of Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study
TL;DR: Chronic inflammation emerges as a new risk factor for the development of type 2 diabetes; PAI-1 predicts type 1 diabetes independent of insulin resistance and other known risk factors for diabetes.
Journal ArticleDOI
Is Type II diabetes mellitus a disease of the innate immune system
John C. Pickup,M. A. Crook +1 more
TL;DR: It is suggested that in Type II diabetes and impaired glucose tolerance long-term lifestyle and environmental stimulants, probably in those with an innately hypersensitive acute-phase response, produce disease instead of repair.