Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis.
Frederikus A. Klok,Marieke J. H. A. Kruip,N.J.M. van der Meer,M.S. Arbous,Diederik Gommers,K.M. Kant,F H J Kaptein,J. van Paassen,M A M Stals,Menno V. Huisman,Henrik Endeman +10 more
TLDR
The very high cumulative incidence of thrombotic complications in critically ill patients with COVID-19 pneumonia is confirmed in this updated analysis.About:
This article is published in Thrombosis Research.The article was published on 2020-07-01 and is currently open access. It has received 1305 citations till now. The article focuses on the topics: Cumulative incidence & Intensive care.read more
Citations
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Cytokine Storm.
David C. Fajgenbaum,Carl H. June +1 more
TL;DR: From the Department of Medicine, Division of Translational Medicine and Human Genetics, Center for Cytokine Storm Treatment and Laboratory, and the Center for Cellular Immunotherapies and the Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia.
Journal ArticleDOI
Incidence of Venous Thromboembolism in Hospitalized Patients with COVID-19
Saskia Middeldorp,Michiel Coppens,Thijs F. van Haaps,Merijn Foppen,Alexander P.J. Vlaar,Marcella C.A. Müller,Catherine C. S. Bouman,Ludo F. M. Beenen,Ruud S. Kootte,Jarom Heijmans,Loek P. Smits,Peter I. Bonta,Nick van Es +12 more
TL;DR: Coronavirus disease 2019 (COVID‐19) can lead to systemic coagulation activation and thrombotic complications and should be treated with anticoagulant medication.
Journal ArticleDOI
Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study.
George Goshua,Alexander B Pine,Matthew L Meizlish,C-Hong Chang,Hanming Zhang,Parveen Bahel,Audrey Baluha,Noffar Bar,Robert D Bona,Adrienne J Burns,Charles S. Dela Cruz,Anne Dumont,Stephanie Halene,John Hwa,Jonathan L. Koff,Hope Menninger,Natalia Neparidze,Christina Price,Jonathan M. Siner,Christopher A. Tormey,Henry M. Rinder,Hyung J. Chun,Alfred Ian Lee +22 more
TL;DR: The findings show that endotheliopathy is present in COVID-19 and is likely to be associated with critical illness and death, and strategies to mitigate its progression might improve outcomes in CO VID-19.
Journal ArticleDOI
COVID-19 and diabetes mellitus: from pathophysiology to clinical management.
TL;DR: Evidence suggests that insulin and dipeptidyl peptidase 4 inhibitors can be used safely in patients with diabetes mellitus and COVID-19; metformin and sodium–glucose cotransporter 2 inhibitors might need to be withdrawn in patients at high risk of severe disease.
Journal ArticleDOI
COVID-19 update: Covid-19-associated coagulopathy.
TL;DR: Emerging insights into the pathobiology, mechanism, diagnosis, management, foundations for research and either planned or ongoing clinical trials for Covid-19-associated coagulopathy are summarized.
References
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Journal ArticleDOI
Pathological findings of COVID-19 associated with acute respiratory distress syndrome.
Zhe Xu,Lei Shi,Yijin Wang,Ji-Yuan Zhang,Lei Huang,Chao Zhang,Shuhong Liu,Peng Zhao,Hongxia Liu,Li Zhu,Yanhong Tai,Changqing Bai,Tingting Gao,Jin-Wen Song,Peng Xia,Jing-Hui Dong,Jingmin Zhao,Fu-Sheng Wang +17 more
TL;DR: O surto do novo coronavÃrus (COVID-19) em Wuhan, China, iniciado em dezembro de 2019, evoluiu para se tornar uma pandemia global A.
Journal ArticleDOI
Incidence of thrombotic complications in critically ill ICU patients with COVID-19.
Frederikus A. Klok,Marieke J. H. A. Kruip,N.J.M. van der Meer,M.S. Arbous,Diederik Gommers,K.M. Kant,F H J Kaptein,J. van Paassen,M A M Stals,Menno V. Huisman,Henrik Endeman +10 more
TL;DR: The findings reinforce the recommendation to strictly apply pharmacological thrombosis prophylaxis in all COVID-19 patients admitted to the ICU, and are strongly suggestive of increasing the prophYLaxis towards high-prophylactic doses, even in the absence of randomized evidence.
Journal ArticleDOI
High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study.
Julie Helms,Charles Tacquard,François Severac,Ian Leonard-Lorant,Mickaël Ohana,Xavier Delabranche,Hamid Merdji,Raphaël Clere-Jehl,Malika Schenck,Florence Fagot Gandet,Samira Fafi-Kremer,Vincent Castelain,Francis Schneider,Lelia Grunebaum,Eduardo Anglés-Cano,Laurent Sattler,Paul-Michel Mertes,Ferhat Meziani +17 more
TL;DR: Despite anticoagulation, a high number of patients with ARDS secondary to COVID-19 developed life-threatening thrombotic complications, and higher antICOagulation targets than in usual critically ill patients should therefore probably be suggested.
Journal ArticleDOI
Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy.
Corrado Lodigiani,G. Iapichino,Luca Carenzo,Maurizio Cecconi,Paola Ferrazzi,Tim Sebastian,Nils Kucher,Jan-Dirk Studt,Clara Sacco,Alexia Bertuzzi,Maria Teresa Sandri,Stefano Barco +11 more
TL;DR: There is an urgent need to improve specific VTE diagnostic strategies and investigate the efficacy and safety of thromboprophylaxis in ambulatory COVID-19 patients.
Journal ArticleDOI
Incidence of Venous Thromboembolism in Hospitalized Patients with COVID-19
Saskia Middeldorp,Michiel Coppens,Thijs F. van Haaps,Merijn Foppen,Alexander P.J. Vlaar,Marcella C.A. Müller,Catherine C. S. Bouman,Ludo F. M. Beenen,Ruud S. Kootte,Jarom Heijmans,Loek P. Smits,Peter I. Bonta,Nick van Es +12 more
TL;DR: Coronavirus disease 2019 (COVID‐19) can lead to systemic coagulation activation and thrombotic complications and should be treated with anticoagulant medication.
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