Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases.
Peter J. Kennelly,E G Krebs +1 more
About:
This article is published in Journal of Biological Chemistry.The article was published on 1991-08-25 and is currently open access. It has received 1311 citations till now. The article focuses on the topics: Kinase & Phosphatase.read more
Citations
More filters
Journal ArticleDOI
Cloned Glutamate Receptors
TL;DR: The application of molecular cloning technology to the study of the glutamate receptor system has led to an explosion of knowledge about the structure, expression, and function of this most important fast excitatory transmitter system in the mammalian brain.
Book ChapterDOI
Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines.
TL;DR: In this paper, the authors focused on interleukin-8 (IL-8) and related chemotactic cytokines, namely, CXC and CC chemokines.
Journal ArticleDOI
Protein Kinase C: Structure, Function, and Regulation
TL;DR: Multiple receptor pathways feeding into multiple lipid pathways have the common end result of activating protein kinase C by production of its second messenger, diacylglycerol.
Journal ArticleDOI
Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease
Kenji Uéda,Hisashi Fukushima,Eliezer Masliah,Yu Xia,Akihiko Iwai,Makoto Yoshimoto,Deborah A. C. Otero,Jun Kondo,Yasuo Ihara,Tsunao Saitoh +9 more
TL;DR: Primary structure predictions indicate that the NAC peptide sequence has a strong tendency to form beta-structures consistent with its association with amyloid, and the availability of the cDNA encoding full-length NACP should help to elucidate the mechanisms of amyloidsosis in AD.
Journal ArticleDOI
Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.
Tetsuya Ohtaki,Yasushi Shintani,Susumu Honda,Hirokazu Matsumoto,Akira Hori,Kimiko Kanehashi,Yasuko Terao,Satoshi Kumano,Yoshihiro Takatsu,Yasushi Masuda,Yoshihiro Ishibashi,Takuya Watanabe,Mari Asada,Takao Yamada,Masato Suenaga,Chieko Kitada,Satoshi Usuki,Tsutomu Kurokawa,Haruo Onda,Osamu Nishimura,Masahiko Fujino +20 more
TL;DR: It is shown that KiSS-1 encodes a carboxy-terminally amidated peptide with 54 amino-acid residues, which is isolated from human placenta as the endogenous ligand of an orphan G-protein-coupled receptor (hOT7T175) and named ‘metastin’.
References
More filters
Journal ArticleDOI
Protein kinase recognition sequence motifs
Bruce E. Kemp,Richard B. Pearson +1 more
TL;DR: Identification of phosphorylation site sequences and studies with corresponding model peptides have provided clues to how these important enzymes recognize their substrate proteins, making it possible to identify potential sites ofosphorylation in newly sequenced proteins.
Journal ArticleDOI
Role of multiple basic residues in determining the substrate specificity of cyclic AMP-dependent protein kinase.
TL;DR: Findings support the idea that multiple basic residues, in particular arginine, on the NH,-terminal side of the phosphorylated serine act as important substrate specificity determinants for the protein kinase.
Journal ArticleDOI
Substrate specificity of protein kinase C: use of synthetic peptides corresponding to physiological sites as probes for substrate recognition requirements
TL;DR: Comparative studies have demonstrated that, in vivo, the enzyme exhibits a preference for one basic residue C-terminal to the phosphorylatable residue, as in the sequence: Ser/Thr-Xaa-Lys/Arg, where Xaa is usually an uncharged residue.
Journal ArticleDOI
Substrates for p34cdc2: In vivo veritas?
Sergio Moreno,Paul Nurse +1 more
TL;DR: Moreno and Nurse as discussed by the authors identified the in vivo substrates of the p34* protein kinase in eukaryotic cells and demonstrated that in vitro sites in vitro should be identical with the phosphoryla- tion sites in vivo.
Journal ArticleDOI
Substrate specificity determinants for casein kinase II as deduced from studies with synthetic peptides.
TL;DR: A relatively short sequence of amino acids surrounding the phosphate acceptor site appears to serve as the basis for the specificity of casein kinase II.
Related Papers (5)
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
A simple method for displaying the hydropathic character of a protein
Jack Kyte,Russell F. Doolittle +1 more