Considerations and code for partial volume correcting [18F]-AV-1451 tau PET data.
TLDR
Binding in the skull and meninges is found near lateral and medial orbitofrontal, lateral occipital, inferior and middle temporal, superior and inferior parietal, and inferior cerebellar gray matter and the choroid plexus shows non-specific binding that bleeds into hippocampus.About:
This article is published in Data in Brief.The article was published on 2017-10-16 and is currently open access. It has received 191 citations till now.read more
Citations
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Journal ArticleDOI
Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease
Anne Maass,Susan M. Landau,Suzanne L. Baker,Andy Horng,Samuel N. Lockhart,Renaud La Joie,Gil D. Rabinovici,William J. Jagust,Alzheimer’s Disease Neuroimaging Initiative +8 more
TL;DR: The data indicate that whole‐brain t Tau PET measures might be adequate biomarkers to detect AD‐related tau pathology, however, regional measures covering AD‐vulnerable regions may increase sensitivity to early tau PET signal, atrophy and memory decline.
Journal ArticleDOI
Prospective longitudinal atrophy in Alzheimer’s disease correlates with the intensity and topography of baseline tau-PET
Renaud La Joie,Adrienne Visani,Suzanne L. Baker,Jesse A. Brown,Viktoriya Bourakova,Jungho Cha,Kiran Chaudhary,Lauren Edwards,Leonardo Iaccarino,Mustafa Janabi,Orit H. Lesman-Segev,Zachary A. Miller,David C. Perry,James P. O'Neil,Julie Pham,Julio C. Rojas,Howard J. Rosen,William W. Seeley,Richard M. Tsai,Bruce L. Miller,William J. Jagust,William J. Jagust,Gil D. Rabinovici +22 more
TL;DR: Quantitative analyses showed that the global intensity of tau-PET, but not β-amyloid–PET, signal predicted the rate of subsequent atrophy, independent of baseline cortical thickness, which support disease models in which tau pathology is a major driver of local neurodegeneration.
Journal ArticleDOI
A walk through tau therapeutic strategies.
Santosh Jadhav,Jesús Avila,Jesús Avila,Michael Schöll,Gabor G. Kovacs,Eniko Veronika Kovari,Rostislav Skrabana,Lewis D. B. Evans,Eva Kontsekova,Barbara Malawska,Rohan de Silva,Luc Buée,Norbert Zilka +12 more
TL;DR: New tau therapeutics, across the board, have demonstrated the ability to prevent or reduce tau lesions and improve either cognitive or motor impairment in a variety of animal models developing neurofibrillary pathology.
Journal ArticleDOI
Entorhinal Tau Pathology, Episodic Memory Decline, and Neurodegeneration in Aging
Anne Maass,Samuel N. Lockhart,Theresa M. Harrison,Rachel K. Bell,Taylor J. Mellinger,Kaitlin N. Swinnerton,Suzanne L. Baker,Gil D. Rabinovici,Gil D. Rabinovici,William J. Jagust,William J. Jagust +10 more
TL;DR: Using tau-specific and Aβ-specific positron emission tomography tracers, it is shown that in vivo MTL tau pathology is associated with episodic-memory performance and MTL atrophy in cognitively normal adults, independent of Aβ.
Journal ArticleDOI
Longitudinal tau accumulation and atrophy in aging and alzheimer disease.
Theresa M. Harrison,Renaud La Joie,Anne Maass,Anne Maass,Suzanne L. Baker,Kaitlin N. Swinnerton,Laura Z. Fenton,Taylor J. Mellinger,Lauren Edwards,Julie Pham,Bruce L. Miller,Gil D. Rabinovici,William J. Jagust,William J. Jagust +13 more
TL;DR: To determine the rate of t Tau accumulation in healthy older adults (OA) and patients with Alzheimer disease (AD), as well as the relationship of tau accumulation to cortical atrophy, a large number of patients with AD are surveyed.
References
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Neuropathological stageing of Alzheimer-related changes.
Heiko Braak,Eva Braak +1 more
TL;DR: The investigation showed that recognition of the six stages required qualitative evaluation of only a few key preparations, permitting the differentiation of six stages.
Journal Article
Correction for Partial Volume Effects in PET: Principle and Validation
TL;DR: A new algorithm to correct for PVEs by characterizing the geometric interaction between the PET system and the brain activity distribution, which allows the correction for Pves simultaneously in all identified brain regions, independent of tracer levels.
Journal ArticleDOI
PET Imaging of Tau Deposition in the Aging Human Brain
Michael Schöll,Michael Schöll,Samuel N. Lockhart,Daniel R. Schonhaut,James P. O'Neil,Mustafa Janabi,Rik Ossenkoppele,Rik Ossenkoppele,Rik Ossenkoppele,Suzanne L. Baker,Jacob W. Vogel,Jamie Faria,Henry Schwimmer,Gil D. Rabinovici,Gil D. Rabinovici,Gil D. Rabinovici,William J. Jagust,William J. Jagust +17 more
TL;DR: In this paper, the authors defined patterns of tau tracer retention in normal aging in relation to age, cognition, and β-amyloid deposition, and found that older age was associated with increased tracers retention in regions of the medial temporal lobe, which predicted worse episodic memory performance.
Journal ArticleDOI
Validating novel tau positron emission tomography tracer [F‐18]‐AV‐1451 (T807) on postmortem brain tissue
Marta Marquié,Marta Marquié,Marc D. Normandin,Charles R. Vanderburg,Isabel Costantino,Elizabeth Bien,Lisa G. Rycyna,William E. Klunk,Chester A. Mathis,Milos D. Ikonomovic,Milos D. Ikonomovic,Manik L. Debnath,Neil Vasdev,Bradford C. Dickerson,Stephen N. Gomperts,John H. Growdon,Keith A. Johnson,Matthew P. Frosch,Bradley T. Hyman,Teresa Gomez-Isla +19 more
TL;DR: The authors examined region and substrate-specific autoradiographic and in vitro binding patterns of positron emission tomography tracer [F-18]-AV-1451 (previously known as T807), tailored to allow in vivo detection of paired helical filament-tau-containing lesions, and to determine whether there is off-target binding to other amyloid/non-amyloid proteins.
Journal ArticleDOI
An autoradiographic evaluation of AV-1451 Tau PET in dementia.
Val J. Lowe,Geoffry L. Curran,Ping Fang,Amanda M. Liesinger,Keith A. Josephs,Joseph E. Parisi,Kejal Kantarci,Bradley F. Boeve,Mukesh K. Pandey,Tyler J. Bruinsma,David S. Knopman,David T.W. Jones,Leonard Petrucelli,Casey Cook,Neill R. Graff-Radford,Dennis W. Dickson,Ronald C. Petersen,Clifford R. Jack,Melissa E. Murray +18 more
TL;DR: Reduced AV-1451 binding in neuritic pathology compared to neurofibrillary tangles suggests that the maturity of tau pathology may affect AV- fourteen51 binding and suggests complexity in AV- 1451 binding.
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