Contribution of microglia-mediated neuroinflammation to retinal degenerative diseases.
TLDR
An overview of the roles of microglia-mediated neuroinflammation in major retinal degenerative diseases like glaucoma, age-related macular degeneration, and diabetic retinopathy is given.Abstract:
Retinal degenerative diseases are major causes of vision loss and blindness worldwide and are characterized by chronic and progressive neuronal loss. One common feature of retinal degenerative diseases and brain neurodegenerative diseases is chronic neuroinflammation. There is growing evidence that retinal microglia, as in the brain, become activated in the course of retinal degenerative diseases, having a pivotal role in the initiation and propagation of the neurodegenerative process. A better understanding of the events elicited and mediated by retinal microglia will contribute to the clarification of disease etiology and might open new avenues for potential therapeutic interventions. This review aims at giving an overview of the roles of microglia-mediated neuroinflammation in major retinal degenerative diseases like glaucoma, age-related macular degeneration, and diabetic retinopathy.read more
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Journal ArticleDOI
The Role of Microglia in Retinal Neurodegeneration: Alzheimer's Disease, Parkinson, and Glaucoma
Ana I. Ramírez,Rosa de Hoz,Elena Salobrar-García,Juan J. Salazar,Blanca Rojas,Daniel Ajoy,Inés López-Cuenca,Pilar Rojas,Pilar Rojas,Alberto Triviño,José Ramírez +10 more
TL;DR: The aim of the present review is to describe the contribution in retina to microglial-mediated neuroinflammation in AD, PD, and glaucomatous neurodegeneration.
Journal ArticleDOI
Microglia in Retinal Degeneration.
TL;DR: This review provides an overview of recent studies that depict microglial responses in diverse retinal pathologies that have degeneration and chronic immune reactions as key pathophysiological components and discusses innovative immunomodulatory therapy strategies that dampen the detrimental immunological responses to improve disease outcome.
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Suppression of Diabetic Retinopathy with Angiopoietin-1
Anthony P. Adamis,Vassiliki Poulaki,Tamim Qaum,Qingwen Xu,Yasufumi Moromizato,S E Bursell,Stanley J. Wiegand,John S. Rudge,George D. Yancopoulos,Antonia M. Joussen +9 more
TL;DR: Angiopoietin-1 is identified as the first naturally occurring protein that directly protects the retinal vasculature in diabetes and is shown to prevent and reverse diabetic retinal vascular changes in both new and established diabetes.
Journal ArticleDOI
PINK1/PARKIN signalling in neurodegeneration and neuroinflammation.
TL;DR: The role of mitochondrial dysfunction in disorders such as amyotrophic lateral sclerosis, Alzheimer's, Huntington’s and Parkinson's diseases, as well as eye diseases such as age-related macular degeneration and glaucoma, and the causative factors leading to PINK1/PARKIN-mediated neurodegeneration and neuroinflammation are debated.
Journal ArticleDOI
Neuroprotective effects of chrysin: From chemistry to medicine
Seyed Fazel Nabavi,Nady Braidy,Solomon Habtemariam,Ilkay Erdogan Orhan,Maria Daglia,Azadeh Manayi,Olga Gortzi,Seyed Mohammad Nabavi +7 more
TL;DR: The present paper aimed to critically review the available literature data regarding the neuroprotective effects of chrysin as well as its chemistry, sources and bioavailability.
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