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Corneal nerves: structure, contents and function.
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TLDR
A revised interpretation of human corneal nerve architecture is presented based on recent observations obtained by in vivo confocal microscopy (IVCM), immunohistochemistry, and ultrastructural analyses of serial-sectionedhuman corneas.About:
This article is published in Experimental Eye Research.The article was published on 2003-05-01. It has received 1010 citations till now. The article focuses on the topics: Neurotrophic keratitis & Cornea.read more
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TFOS DEWS II pathophysiology report
Anthony J. Bron,Anthony J. Bron,Cintia S. de Paiva,Sunil K. Chauhan,Stefano Bonini,Eric E. Gabison,Sandeep Jain,Erich Knop,Maria Markoulli,Yoko Ogawa,Victor L. Perez,Yuichi Uchino,Norihiko Yokoi,Driss Zoukhri,David A. Sullivan +14 more
TL;DR: The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms involved in the initiation and perpetuation of dry eye disease, finding the targeting of the terminal duct in meibomian gland disease and the influence of gaze dynamics and the closed eye state on tear stability and ocular surface inflammation to be important.
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Semaphorin3A induces nerve regeneration in the adult cornea-a switch from its repulsive role in development
TL;DR: In this paper, the authors investigated the neuro-regenerative potential of Sema3A on adult peripheral nervous system neurons such as those that innervate the cornea and found that upon cornea injury, there is a fast increase in Semaphorin3A expression.
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A Randomized, Controlled Trial of Corneal Collagen Cross-Linking in Progressive Keratoconus: Three-Year Results
Christine Wittig-Silva,Elsie Chan,Fakir M. Amirul Islam,Tony Wu,Mark Whiting,Grant R. Snibson +5 more
TL;DR: At 36 months, there was a sustained improvement in Kmax, UCVA, and BSCVA after CXL, whereas eyes in the control group demonstrated further progression, and corneal thickness at the thinnest point was reduced.
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Dry eye disease: an immune-mediated ocular surface disorder.
TL;DR: The fundamental links between inflammation and dry eye disease are reviewed and the clinical implications of inflammation in disease management are discussed and the self-perpetuating inflammatory cycle is discussed.
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Neural basis of sensation in intact and injured corneas.
TL;DR: Corneal nerves destroyed by injury soon start to regenerate and form microneuromas that exhibit abnormal responsiveness and spontaneous discharges, due to an altered expression of ion channel proteins in the soma and in regenerating nerve terminals.
References
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Regulation of cell survival by secreted proneurotrophins.
TL;DR: It is shown that the proforms of nerve growth factor (NGF) and the pro forms of brain derived neurotrophic factor (BDNF) are secreted and cleaved extracellularly by the serine protease plasmin and by selective matrix metalloproteinases (MMPs).
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Differentiation-related expression of a major 64K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cells.
TL;DR: Keratin expression data suggest that the acidic 55K and basic 64K keratins represent markers for an advanced stage of corneal epithelial differentiation.
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GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF
Shuqian Jing,Duanzhi Wen,Yanbin Yu,Paige Holst,Yi Luo,Mei Fang,Rami Tamir,Laarni Antonio,Zheng Hu,Rod Cupples,Jean-Claude Louis,Sylvia Hu,Bruce W. Altrock,Gary M. Fox +13 more
TL;DR: In this paper, the expression cloning and characterization of GDNFR-α, a novel glycosylphosphatidylinositol-linked cell surface receptor for glial cell line-derived neurotrophic factor (GDNF), was reported.