Journal ArticleDOI
Curcumin induces stress response, neurite outgrowth and prevent NF-kappaB activation by inhibiting the proteasome function.
TLDR
It is shown that curcumin disrupts UPS function by directly inhibiting the enzyme activity of the proteasome’s 20S core catalytic component, which causes an increase in half-life of IκB-α that ultimately leads to the down-regulation of NF-κB activation.Abstract:
Curcumin, a natural polyphenolic compound, has long been known as an anti-tumour and anti-inflammatory compound; although, the common mechanism through which it exhibits such properties are remains unclear. Recently, we reported that the curcumin-induced apoptosis is mediated through the impairment of ubiquitin proteasome system (UPS). Here, we show that curcumin disrupts UPS function by directly inhibiting the enzyme activity of the proteasome's 20S core catalytic component. Like other proteasome inhibitors, curcumin exposure induces neurite outgrowth and the stress response, as evident from the induction of various cytosolic and endoplasmic reticulum chaperones as well as induction of transcription factor CHOP/GADD153. The direct inhibition of proteasome activity also causes an increase in half-life of IkappaB-alpha that ultimately leads to the down-regulation of NF-kappaB activation. These results suggest that curcumin-induced proteasomal malfunction might be linked with both anti-proliferative and anti-inflammatory activities.read more
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Induction of full-length survival motor neuron by polyphenol botanical compounds
TL;DR: Curcumin, EGCG, and resveratrol increased exon 7 inclusion of SMN2 transcripts in transient reporter assays, and these compounds stimulated the production of full-length SMN RNA and protein as well as the formation ofSMN-containing nuclear gems in SMA patient fibroblasts.
Journal ArticleDOI
Targeting proteasomal pathways by dietary curcumin for cancer prevention and treatment.
TL;DR: Curcumin, a major component of the golden spice turmeric (Curcuma longa), has been linked with the prevention and treatment of a wide variety of cancers through modulation of multiple cell signaling pathways as discussed by the authors.
Journal ArticleDOI
Chalcone-based small-molecule inhibitors attenuate malignant phenotype via targeting deubiquitinating enzymes
TL;DR: Evidence of antitumor activity of novel chalcone-based derivatives mediated by their DUB-targeting capacity is provided, which supports the development of pharmaceuticals to directly target DUB as a most efficient strategy compared with proteasome inhibition and provides a clear rationale for the clinical evaluation of these novel small-molecule DUB inhibitors.
Journal Article
Curcumin: from food spice to cancer prevention.
TL;DR: Curcumin is a potent inhibitor of cytochrome P450 with capacity to simultaneously induce detoxifying enzymes such as glutathione S-transferase and as such may find application as a chemopreventive agent.
Journal ArticleDOI
Neurite Outgrowth Effect of 4- O -methylhonokiol by Induction of Neurotrophic Factors Through ERK Activation
Yong Kyoung Lee,Im Seop Choi,Young Heui Kim,Ki Ho Kim,Sang Yun Nam,Young Won Yun,Moon Soon Lee,Ki Wan Oh,Jin Tae Hong +8 more
TL;DR: 4-O-methylhonokiol has the ability to induce neurite outgrowth via the increase of neurotrophic factor levels through ERK activation, as well as neuroprotective effects against chemical and heat damages.
References
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Journal ArticleDOI
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
TL;DR: It is clear now that degradation of cellular proteins is a highly complex, temporally controlled, and tightly regulated process that plays major roles in a variety of basic pathways during cell life and death as well as in health and disease.
Journal Article
Anticancer potential of curcumin: preclinical and clinical studies.
TL;DR: Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis, and Pharmacologically,Curcumin has been found to be safe.
Journal ArticleDOI
Pharmacology of Curcuma longa
TL;DR: It appears that when given orally, curcumin is far less active than after i.p. administration, and systemic effects seem to be questionable after oral application except that they occur at very low concentrations ofCurcumin, which does not exclude a local action in the gastrointestinal tract.
Journal ArticleDOI
Activation of Transcription Factor NF-κB Is Suppressed by Curcumin (Diferuloylmethane)
Sanjaya Singh,Bharat B. Aggarwal +1 more
TL;DR: It is demonstrated that curcumin (diferuloylmethane), a known anti-inflammatory and anticarcinogenic agent, is a potent inhibitor of NF-κB activation.
Journal ArticleDOI
Molecular sequelae of proteasome inhibition in human multiple myeloma cells
Nicholas Mitsiades,Constantine S. Mitsiades,Vassiliki Poulaki,Dharminder Chauhan,Galinos Fanourakis,Xuesong Gu,Charles G. Bailey,Marie Joseph,Towia A. Libermann,Steven P. Treon,Nikhil C. Munshi,Paul G. Richardson,Teru Hideshima,Kenneth C. Anderson +13 more
TL;DR: The molecular sequelae of PS-341 treatment in MM cells are characterized and the rationale for future clinical trials of this promising agent, in combination with conventional and novel therapies, to improve patient outcome in MM is explained.
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Activation of Transcription Factor NF-κB Is Suppressed by Curcumin (Diferuloylmethane)
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