Journal ArticleDOI
Curcumin induces stress response, neurite outgrowth and prevent NF-kappaB activation by inhibiting the proteasome function.
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TLDR
It is shown that curcumin disrupts UPS function by directly inhibiting the enzyme activity of the proteasome’s 20S core catalytic component, which causes an increase in half-life of IκB-α that ultimately leads to the down-regulation of NF-κB activation.Abstract:
Curcumin, a natural polyphenolic compound, has long been known as an anti-tumour and anti-inflammatory compound; although, the common mechanism through which it exhibits such properties are remains unclear. Recently, we reported that the curcumin-induced apoptosis is mediated through the impairment of ubiquitin proteasome system (UPS). Here, we show that curcumin disrupts UPS function by directly inhibiting the enzyme activity of the proteasome's 20S core catalytic component. Like other proteasome inhibitors, curcumin exposure induces neurite outgrowth and the stress response, as evident from the induction of various cytosolic and endoplasmic reticulum chaperones as well as induction of transcription factor CHOP/GADD153. The direct inhibition of proteasome activity also causes an increase in half-life of IkappaB-alpha that ultimately leads to the down-regulation of NF-kappaB activation. These results suggest that curcumin-induced proteasomal malfunction might be linked with both anti-proliferative and anti-inflammatory activities.read more
Citations
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Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?
TL;DR: Curcumin modulates growth of tumor cells through regulation of multiple cell signaling pathways including cell proliferation pathway, cell survival pathway, and protein kinase pathway.
Journal ArticleDOI
The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders
Magdalena Działo,Justyna Mierziak,Urszula Korzun,Marta Preisner,Jan Szopa,Jan Szopa,Anna Kulma +6 more
TL;DR: This paper reviews the latest reports on the potential therapy of skin disorders through treatment with phenolic compounds, considering mostly a single specific compound or a combination of compounds in a plant extract.
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Role of curcumin in cancer therapy
TL;DR: Curcumin has been shown to have protective and therapeutic effects against cancers of the blood, skin, oral cavity, lung, pancreas, and intestinal tract, and to suppress angiogenesis and metastasis in rodents.
Journal ArticleDOI
The Multifaceted Role of Curcumin in Cancer Prevention and Treatment
Muthu K. Shanmugam,Grishma Rane,Madhu Mathi Kanchi,Frank Arfuso,Arunachalam Chinnathambi,M. E. Zayed,Sulaiman Ali Alharbi,Benny K. H. Tan,Alan Prem Kumar,Gautam Sethi,Gautam Sethi,Gautam Sethi +11 more
TL;DR: The current review focuses on the diverse molecular targets modulated by curcumin that contribute to its efficacy against various human cancers.
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Multi-targeted therapy by curcumin: how spicy is it?
TL;DR: Curcumin regulates multiple targets (multitargeted therapy), which is needed for treatment of most diseases, and it is inexpensive and has been found to be safe in human clinical trials.
References
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Journal ArticleDOI
Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor–κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis
TL;DR: It is found that curcumin down-regulates NF-κB in human MM cells, leading to the suppression of proliferation and induction of apoptosis, thus providing the molecular basis for the treatment of MM patients with this pharmacologically safe agent.
Journal Article
Inhibitory Effects of Dietary Curcumin on Forestomach, Duodenal, and Colon Carcinogenesis in Mice
TL;DR: Results indicate that not only did curcumin inhibit the number of tumors per mouse and the percentage of mice with tumors but it also reduced tumor size.
Journal ArticleDOI
Activation of the cell death program by inhibition of proteasome function
TL;DR: Proteasomal activity appears to be required in proliferating, but not in quiescent, HL60 cells for cell survival as well as normal progression through the cell cycle.
Journal ArticleDOI
Proteasome Inhibition Leads to a Heat-shock Response, Induction of Endoplasmic Reticulum Chaperones, and Thermotolerance
TL;DR: The findings suggest that inhibition of proteasome function induces heat-shock proteins and ER chaperones due to the accumulation of sufficient amounts of abnormal proteins and/or the inhibition of degradation of a key regulatory factor (e.g. heat- shock factor).
Journal ArticleDOI
p53-dependent Induction of Apoptosis by Proteasome Inhibitors
TL;DR: Results suggest that stabilization and accumulation of p53 plays a key role in apoptosis induced by proteasome inhibitors, and that other molecules may also be involved.
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