Journal ArticleDOI
Cutaneous delayed-type hypersensitivity in patients with atopic dermatitis
Dana Malajian,Donald V. Belsito +1 more
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Compared with nonatopics, patients with AD are significantly more likely to have at least 1 positive patch test reaction and to develop contact hypersensitivity to metal allergens.Abstract:
Background Literature on the relationship between atopic dermatitis (AD) and cutaneous delayed-type hypersensitivity is inconclusive. Objective We sought to compare the rates of positive patch test reactions to allergens on the North American Contact Dermatitis Group (NACDG) standard tray among patients with and without AD, and, to assess whether atopic patients in our database were more likely to patch test positive to certain classes of allergens. Methods A total of 2305 patients underwent patch testing to the NACDG standard screening series. The incidence of positive patch test reactions among patients with AD (n = 297) and without AD (n = 2008) was assessed. Statistical analysis was done using a χ 2 test with Yates continuity correction. Results Compared with nonatopic patients, those with AD were statistically more likely to have positive patch tests. AD was associated with contact hypersensitivity to nickel, cobalt, and chromium, but was not associated with contact sensitization to fragrances. Limitations Only patients suspected of having allergic contact dermatitis were tested. Our population was geographically limited to metropolitan Kansas City (including Kansas City, MO, Kansas City, KS, and the adjoining suburbs). Conclusion Compared with nonatopics, patients with AD are significantly more likely to have at least 1 positive patch test reaction and to develop contact hypersensitivity to metal allergens.read more
Citations
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Journal ArticleDOI
Comorbidities and the impact of atopic dermatitis.
TL;DR: This review summarizes recent developments in the burden and comorbidities of Atopic dermatitis, a chronic pruritic inflammatory skin disease with substantial patient and population burdens that may predispose to higher risk of other atopic disorders.
Journal ArticleDOI
When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council
Eric L. Simpson,Marjolein S. de Bruin-Weller,Carsten Flohr,Michael R. Ardern-Jones,Sébastien Barbarot,Mette Deleuran,Thomas Bieber,Christian Vestergaard,Sara J. Brown,Sara J. Brown,Michael J. Cork,Aaron M. Drucker,Lawrence F. Eichenfield,Lawrence F. Eichenfield,Regina Foelster-Holst,Emma Guttman-Yassky,Audrey Nosbaum,Nick J. Reynolds,Nick J. Reynolds,Jonathan I. Silverberg,Jochen Schmitt,Marieke M B Seyger,Phyllis I. Spuls,Jean-François Stalder,John C Su,Roberto Takaoka,Claudia Traidl-Hoffmann,Jacob P. Thyssen,Jorien van der Schaft,Andreas Wollenberg,Alan D. Irvine,Amy S. Paller,Amy S. Paller +32 more
TL;DR: The decision to start systemic medication should include assessment of severity and quality of life while considering the individual's general health status, psychologic needs, and personal attitudes toward systemic therapies.
Journal ArticleDOI
Nickel allergy and allergic contact dermatitis: A clinical review of immunology, epidemiology, exposure, and treatment.
TL;DR: This clinical review provides an updated overview of the epidemiology, exposure sources, methods for exposure quantification, skin deposition and penetration, immunology, diagnosis, thresholds for sensitization and elicitation, clinical pictures, prevention, and treatment of nickel allergy.
Journal ArticleDOI
The multiple factors affecting the association between atopic dermatitis and contact sensitization
TL;DR: It is concluded that multiple factors affect the association between atopic dermatitis and contact sensitization, and that these need to be appreciated in the clinical management of atopy dermatitis patients.
Journal ArticleDOI
Petrolatum: Barrier repair and antimicrobial responses underlying this “inert” moisturizer
Tali Czarnowicki,Dana Malajian,Dana Malajian,Saakshi Khattri,Saakshi Khattri,Joel Correa da Rosa,Riana Dutt,Riana Dutt,Robert Finney,Nikhil Dhingra,Peng Xiangyu,Peng Xiangyu,Hui Xu,Hui Xu,Yeriel Estrada,Xiuzhong Zheng,Patricia Gilleaudeau,Mary Sullivan-Whalen,Mayte Suárez-Fariñas,Avner Shemer,James G. Krueger,Emma Guttman-Yassky,Emma Guttman-Yassky +22 more
TL;DR: Petrolatum robustly modulates antimicrobials and epidermal differentiation barrier measures and shed light on the beneficial molecular responses of petrolatum in barrier-defective states, such as AD and postoperative wound care.
References
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Journal ArticleDOI
Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis
Colin N. A. Palmer,Alan D. Irvine,Ana Terron-Kwiatkowski,Yiwei Zhao,Haihui Liao,Simon P. Lee,David Goudie,Aileen Sandilands,Linda E. Campbell,Frances J.D. Smith,Grainne M. O'Regan,Rosemarie Watson,Jo E Cecil,Sherri J. Bale,John G. Compton,John J. DiGiovanna,John J. DiGiovanna,Philip Fleckman,Sue Lewis-Jones,Gehan Arseculeratne,Ann Sergeant,Colin S. Munro,Brahim El Houate,Ken McElreavey,Liselotte Brydensholt Halkjaer,Hans Bisgaard,Somnath Mukhopadhyay,Somnath Mukhopadhyay,W.H. Irwin McLean +28 more
TL;DR: It is shown that two independent loss-of-function genetic variants (R510X and 2282del4) in the gene encoding filaggrin (FLG) are very strong predisposing factors for atopic dermatitis.
Journal ArticleDOI
Atopic dermatitis and the atopic march.
TL;DR: Preliminary prevention studies with oral antihistamines provide evidence that early intervention might slow the atopic march, which has a tremendously negative effect on the quality of life of patients as well as family.
Journal ArticleDOI
The epidemiology of contact allergy in the general population – prevalence and main findings
TL;DR: A median prevalence of nickel allergy was determined and demonstrates that nickel was an important cause of contact allergy in the general population and that it was widespread in both men and women.
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