Cyclic AMP signaling reduces sirtuin 6 expression in non-small cell lung cancer cells by promoting ubiquitin-proteasomal degradation via inhibition of the Raf-MEK-ERK (Raf/mitogen-activated extracellular signal-regulated kinase/extracellular signal-regulated kinase) pathway.
Eui Jun Kim,Yong Sung Juhnn +1 more
Reads0
Chats0
TLDR
It is concluded that cAMP signaling reduces SIRT6 expression by promoting its ubiquitin-proteasome-dependent degradation, a process mediated by the PKA-dependent inhibition of the Raf-MEK-ERK pathway.About:
This article is published in Journal of Biological Chemistry.The article was published on 2015-04-10 and is currently open access. It has received 52 citations till now. The article focuses on the topics: Autocrine signalling & Cell signaling.read more
Citations
More filters
Journal ArticleDOI
SIRT6: Novel Mechanisms and Links to Aging and Disease.
TL;DR: New discoveries and models of SIRT6 biology are reviewed in four areas: heterochromatin stabilization and silencing; stem cell biology; cancer initiation and progression; and regulation of metabolic homeostasis.
Journal ArticleDOI
Complex roles of cAMP-PKA-CREB signaling in cancer.
TL;DR: The important roles of cAMP–PKA–CREB signaling in tumorigenesis are highlighted and the potential strategies to target this pathway for cancer therapy are discussed.
Journal ArticleDOI
Microarray profile of circular RNAs identifies hsa_circ_0014130 as a new circular RNA biomarker in non-small cell lung cancer.
TL;DR: Gene oncology analysis and pathway analysis revealed that hsa_circ_0014130 could participate in NSCLC development and might be closely related to the carcinogenesis ofNSCLC.
Journal ArticleDOI
Sirtuins in metabolism, DNA repair and cancer
TL;DR: Current knowledge on the functions of sirtuins mainly regarding DNA repair and energy metabolism are summarized, and the implication of sIRTuins in cancer specifically by regulating genome integrity and cancer-related metabolism is discussed.
Journal ArticleDOI
SIRT6, a Mammalian Deacylase with Multitasking Abilities.
TL;DR: This Review will attempt to provide a framework for the ability of SIRT6 to interconnect chromatin dynamics with metabolism and DNA repair, and the open questions the field will face in the future, particularly in the context of putative therapeutic opportunities.
References
More filters
Journal ArticleDOI
Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
Journal ArticleDOI
Changing Epidemiology of Small-Cell Lung Cancer in the United States Over the Last 30 Years: Analysis of the Surveillance, Epidemiologic, and End Results Database
Ramaswamy Govindan,Nathan C. Page,Daniel Morgensztern,William L. Read,Ryan M. Tierney,Anna Vlahiotis,Edward L. Spitznagel,Jay F. Piccirillo +7 more
TL;DR: The analysis indicates that the incidence of SCLC is decreasing in the United States, and only modest improvements have been seen in survival over the last 30 years.
Journal ArticleDOI
Functions of site-specific histone acetylation and deacetylation.
TL;DR: In this article, the degree of chromatin compaction and folding may be regulated by acetylation of histone H4 at lysine 16, which is important for spreading of heterochromatin components.
Journal ArticleDOI
Recent progress in the biology and physiology of sirtuins
TL;DR: The recent progress in sirtuin biology, the role these proteins have in various age-related diseases and the tantalizing notion that the activity of this family of enzymes somehow regulates how long the authors live are reviewed.
Journal ArticleDOI
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
Eriko Michishita,Ronald A. McCord,Elisabeth Berber,Mitomu Kioi,Hesed Padilla-Nash,Mara Damian,Peggie Cheung,Rika Kusumoto,Tiara L.A. Kawahara,J. Carl Barrett,Howard Y. Chang,Vilhelm A. Bohr,Thomas Ried,Or Gozani,Katrin F. Chua +14 more
TL;DR: The human SIRT6 protein is an NAD+-dependent, histone H3 lysine 9 (H3K9) deacetylase that modulates telomeric chromatin and contributes to the propagation of a specialized chromatin state at mammalian telomeres, which in turn is required for proper telomere metabolism and function.
Related Papers (5)
The Histone Deacetylase SIRT6 Is a Tumor Suppressor that Controls Cancer Metabolism
Carlos Sebastian,Bernadette M. M. Zwaans,Dafne Magalí Silberman,Dafne Magalí Silberman,Melissa Gymrek,Alon Goren,Lei Zhong,Oren Ram,Jessica Truelove,Alexander R. Guimaraes,Debra Toiber,Claudia Cosentino,Joel K. Greenson,Alasdair I. MacDonald,Liane M. McGlynn,Fraser Maxwell,Joanne Edwards,Sofia Giacosa,Ernesto Guccione,Ralph Weissleder,Bradley E. Bernstein,Aviv Regev,Aviv Regev,Aviv Regev,Paul G. Shiels,David B. Lombard,Raul Mostoslavsky +26 more
Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6
Raul Mostoslavsky,Katrin F. Chua,Katrin F. Chua,David B. Lombard,Wendy W. Pang,Miriam R. Fischer,Lionel Gellon,Pingfang Liu,Gustavo Mostoslavsky,Sonia Franco,Michael M. Murphy,Kevin D. Mills,Parin Patel,Joyce T. Hsu,Andrew L. Hong,Ethan Ford,Hwei Ling Cheng,Caitlin Kennedy,Nomeli P. Nunez,Nomeli P. Nunez,Roderick T. Bronson,David Frendewey,Wojtek Auerbach,David M. Valenzuela,Margaret Karow,Michael O. Hottiger,Stephen D. Hursting,J. Carl Barrett,J. Carl Barrett,Leonard Guarente,Richard C. Mulligan,Bruce Demple,George D. Yancopoulos,Frederick W. Alt +33 more