Journal ArticleDOI
Cylindrospermopsin: a potent hepatotoxin from the blue-green alga Cylindrospermopsis raciborskii
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This article is published in Journal of the American Chemical Society.The article was published on 1992-09-01. It has received 534 citations till now. The article focuses on the topics: Cylindrospermopsis raciborskii & Cylindrospermopsis.read more
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Journal ArticleDOI
Validation of a Method for Cylindrospermopsin Determination in Vegetables: Application to Real Samples Such as Lettuce (Lactuca sativa L.).
Ana I. Prieto,Remedios Guzmán-Guillén,Leticia Díez-Quijada,Alexandre Campos,Vitor Vasconcelos,Ángeles Jos,Ana M. Cameán +6 more
TL;DR: The validated method showed good results in terms of sensitivity, precision, accuracy, and robustness for CYN determination in leaf vegetables such as lettuce, and it was successfully applied to quantify CYN in edible lettuce leaves exposed to CYN-contaminated water.
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Modulation of chromatin remodelling induced by the freshwater cyanotoxin cylindrospermopsin in human intestinal caco-2 cells.
Antoine Huguet,Aurélie Hatton,Romain Villot,Hélène Quenault,Yannick Blanchard,Valérie Fessard +5 more
TL;DR: Cylindrospermopsin overexpressed proteins involved in DNA damage repair and transcription, including modifications of nucleosomal histones, which is essential for initiating transcription.
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Histopathological and immunohistochemical analysis of Tilapia (Oreochromis niloticus) exposed to cylindrospermopsin and the effectiveness of N-Acetylcysteine to prevent its toxic effects.
Daniel Gutiérrez-Praena,María Ángeles Risalde,Silvia Pichardo,Ángeles Jos,Rosario Moyano,Alfonso Blanco,Vitor Vasconcelos,Ana M. Cameán +7 more
TL;DR: NAC can be considered a useful chemoprotectant in the prophylaxis and treatment of CYN-related intoxications in fish, as it reduced the number of immunopositive cases in a dose-dependent way.
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Identification of two residues essential for the stringent substrate specificity and active site stability of the prokaryotic l-arginine:glycine amidinotransferase CyrA.
TL;DR: Overall, the results indicated that these two residues are essential for both stringent substrate specificity and the active site stability and flexibility of this unique cyanobacterial enzyme.
Journal ArticleDOI
Cytotoxic effects of cylindrospermopsin in mitotic and non-mitotic Vicia faba cells.
Tamás Garda,Milán Riba,Gábor Vasas,Dániel Beyer,Márta M-Hamvas,Gréta Hajdu,Ildikó Tándor,Csaba Máthé +7 more
TL;DR: Cylindrospermopsin induced the formation of double, split and asymmetric preprophase bands (PPBs) in parallel with the alteration of cell division planes, related to the interference of cyanotoxin with protein synthesis, thus it was a plant- and CYN specific alteration.