Cytoplasmic functions of the tumour suppressor p53
TLDR
An emerging area of research unravels additional activities of p53 in the cytoplasm, where it triggers apoptosis and inhibits autophagy, which contribute to the mission of p 53 as a tumour suppressor.Abstract:
The principal tumour-suppressor protein, p53, accumulates in cells in response to DNA damage, oncogene activation and other stresses. It acts as a nuclear transcription factor that transactivates genes involved in apoptosis, cell cycle regulation and numerous other processes. An emerging area of research unravels additional activities of p53 in the cytoplasm, where it triggers apoptosis and inhibits autophagy. These previously unknown functions contribute to the mission of p53 as a tumour suppressor.read more
Citations
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Autophagy and the Integrated Stress Response
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Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
TL;DR: The biochemical, structural and genetic studies that have clarified how the interplay between members of the BCL-2 family on mitochondria sets the apoptotic threshold are discussed, illuminating the physiological control of apoptosis, the pathological consequences of its dysregulation and the promising search for novel cancer therapies that target the BCA2 protein family.
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The first 30 years of p53: growing ever more complex
Arnold J. Levine,Moshe Oren +1 more
TL;DR: Thirty years ago p53 was discovered as a cellular partner of simian virus 40 large T-antigen, the oncoprotein of this tumour virus, and new functions of this protein were revealed, including the regulation of metabolic pathways and cytokines that are required for embryo implantation.
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Molecular Genetics of Colorectal Cancer
TL;DR: In this article, a review of gene mutations in colorectal cancer is presented, focusing on the nature and significance of individual and collective genetic and epigenetic defects in CRC.
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Crosstalk between apoptosis, necrosis and autophagy.
TL;DR: The recent literature that highlights the intricate interplay between apoptosis, necrosis and autophagy is reviewed, focusing on the relevance and impact of this crosstalk in normal development and in pathology.
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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
Jerry E. Chipuk,Tomomi Kuwana,Lisa Bouchier-Hayes,Nathalie Droin,Donald D. Newmeyer,Martin Schuler,Douglas R. Green +6 more
TL;DR: It is proposed that when p53 accumulates in the cytosol, it can function analogously to the BH3-only subset of proapoptotic Bcl-2proteins to activate Bax and trigger apoptosis.
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Transcriptional control of human p53-regulated genes
TL;DR: The most comprehensive list so far of human p53-regulated genes and their experimentally validated, functional binding sites that confer p53 regulation is presented.