Cytotoxic Activity Of Non Polar Fraction From Annona Muricata L. Leaves On Hela And Raji Cell Line
Anif Nur Artanti,Okid Parama Astirin,Adi Prayitno +2 more
- Vol. 1, Iss: 2, pp 112-118
TLDR
The focus of this study was to develop the potency of non polar fraction from Annona muricata L. leaves by observing the cytotoxic effect on Hela and Raji cancer cell line.Abstract:
The main focus of the research is cancer by a viral infection such as nasopharinx and cervical cancer that have high incidence in Indonesia. Cervical cancer is due to the viral infection known as the Human Papilloma Virus (HPV) and nasopharing cancer is a cancer that is caused by EBV infection (Eppstein Barr virus). The main priority of nasopharinx and servix cancer treatment is the use of chemotherapeutic agents, but it might also lead to diverse side-effects. The focus of this study was to develop the potency of non polar fraction from Annona muricata L. leaves by observing the cytotoxic effect on Hela and Raji cancer cell line.read more
Citations
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Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects.
TL;DR: The reported toxicity notwithstanding, A. muricata extracts seem to be some of the safest and promising therapeutic agents of the 21st century and beyond that need to be studied further for better medicinal formulations and diseases management.
Journal ArticleDOI
Exploring the Leaves of Annona muricata L. as a Source of Potential Anti-inflammatory and Anticancer Agents
TL;DR: The present knowledge of the plant has been critically assessed, aimed at improving its prospect as a source of potential anti-inflammatory and anticancer agents and will provide a new path for ensuring research on this plant to discover new agents to treat inflammatory diseases and cancer.
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Medicinal plants used in traditional management of cancer in Uganda: A review of ethnobotanical surveys, phytochemistry, and anticancer studies
Timothy Omara,Ambrose Kiprop,Rose C. Ramkat,Jackson K. Cherutoi,Sarah Kagoya,Decrah Moraa Nyangena,Tsedey Azeze Tebo,Papias Nteziyaremye,Lucy Nyambura Karanja,Abigael Jepchirchir,Alfayo Maiyo,Betty Jematia Kiptui,Immaculate Mbabazi,Caroline Kiwanuka Nakiguli,Caroline Kiwanuka Nakiguli,Brenda Victoria Nakabuye,Margaret Chepkemoi Koske,Margaret Chepkemoi Koske +17 more
TL;DR: There is a need to isolate and evaluate the anticancer potential of the bioactive compounds in the unstudied claimed plants, such as Cyperus alatus (Nees) F.f.), Ficus dawei Hutch.
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HPLC determination of caffeine in coffee beverage
B E P Fajara,Hari Susanti +1 more
TL;DR: In this article, the authors used HPLC method to determine the level of caffeine in coffee beverages with three branded coffee beverages which include in 3 of Top Brand Index 2016 Phase 2 were used as samples.
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Metabolic Enzyme Inhibitory and Larvicidal Activity of Biosynthesized and Heat Stabilized Silver Nanoparticles Using Annona muricata Leaf Extract
S.B. Santhosh,Devarajan Natarajan,Paramasivam Deepak,B. Gayathri,L. Kaviarasan,P. Naresh,M.J. Nanjan,M.J.N. Chandrasekar +7 more
TL;DR: In this paper, the synthesis of silver nanoparticles (AgNPs) using Annona muricata (A. murica) leaf extract and its larvicidal, metabolic enzyme inhibitory properties was demonstrated.
References
More filters
Journal ArticleDOI
Natural Products as Sources of New Drugs over the Last 25 Years
David J. Newman,Gordon M. Cragg +1 more
TL;DR: This review is an updated and expanded version of two prior reviews that were published in this journal in 1997 and 2003 and is able to identify only one de novo combinatorial compound approved as a drug in this 25 plus year time frame.
Journal ArticleDOI
Molecular mechanisms of resistance and toxicity associated with platinating agents.
Cara A. Rabik,M. Eileen Dolan +1 more
TL;DR: Preclinical data that has clinical relevance generated over the past five years of platinating agents, including cisplatin, carboplatin, and oxaliplatin are focused on.
Journal ArticleDOI
Global burden of human papillomavirus and related diseases.
David Forman,Catherine de Martel,Charles J.N. Lacey,Isabelle Soerjomataram,Joannie Lortet-Tieulent,Laia Bruni,Jérôme Vignat,Jacques Ferlay,Freddie Bray,Martyn Plummer,Silvia Franceschi +10 more
TL;DR: Cervical cancer is the third most common female malignancy and shows a strong association with level of development, rates being at least four-fold higher in countries defined within the low ranking of the Human Development Index (HDI) compared with those in the very high category.
Journal ArticleDOI
Mechanisms of Cisplatin nephrotoxicity.
TL;DR: Recent advances in understanding of cisplatin nephrotoxicity are summarized and it is discussed how these advances might lead to more effective prevention.
Journal ArticleDOI
Cytotoxic activity screening of some indigenous Thai plants
TL;DR: The extracts of Polyalthia evecta and Erythroxylum cuneatum showed potent anticancer activity in the HepG2 cell line with IC(50) of 70+/-3 microg/ml and 64+/-4 microG/ml, respectively, indicating its potential for biopharmaceutical use.