Journal ArticleDOI
D-lactate production in erythrocytes infected with Plasmodium falciparum.
TLDR
D-Lactate production by the parasite appears to be a defense mechanism to protect the parasite from the toxic effects of methylglyoxal.About:
This article is published in Molecular and Biochemical Parasitology.The article was published on 1990-09-01. It has received 131 citations till now. The article focuses on the topics: Methylglyoxal & Lactoylglutathione lyase.read more
Citations
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Journal ArticleDOI
Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification--a role in pathogenesis and antiproliferative chemotherapy.
TL;DR: The modification of nucleic acids and protein by methylglyoxal is a signal for their degradation and may have a role in the development of diabetic complications, atherosclerosis, the immune response in starvation, aging and oxidative stress.
Journal ArticleDOI
Methylglyoxal in living organisms: chemistry, biochemistry, toxicology and biological implications.
TL;DR: A comprehensive overview of methylglyoxal research, extending discussion from chemistry to biological implications by reviewing some important characteristics of methyl glyoxal metabolism and toxicity in a wide variety of species, and emphasizing the action of methyl-oxoaldehyde production in the environment as a potential risk factor and to the possible role of this a-dicarbonyl in diseases as discussed by the authors.
Journal ArticleDOI
Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems - role in ageing and disease
TL;DR: It is appreciated that glyoxalase 1 protects against dicarbonyl modifications of the proteome, genome and lipome and represents part of the enzymatic defence against glycation.
Journal ArticleDOI
Membrane Transport in the Malaria-Infected Erythrocyte
TL;DR: This review focuses on the transport properties of the different membranes of the malaria-infected erythrocyte, as well as on the role played by the various membrane transport systems in the uptake of solutes from the extracellular medium, the disposal of metabolic wastes, and the origin and maintenance of electrochemical ion gradients.
Book ChapterDOI
The pathophysiology of malaria.
Nicholas J. White,May Ho +1 more
TL;DR: Understanding of pathophysiological mechanisms in malaria has advanced considerably in areas, such as the pathogenesis of metabolic dysfunction, the molecular processes involved in cytoadherence, and the causes of anaemia, but in other areas progress has been slow.
References
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Journal ArticleDOI
Human malaria parasites in continuous culture
William Trager,James B. Jensen +1 more
TL;DR: Plasmodium falciparum can now be maintained in continuous culture in human erythrocytes incubated at 38 degrees C in RPMI 1640 medium with human serum under an atmosphere with 7 percent carbon dioxide and low oxygen.
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Measurement of the Lactate Dehydrogenase Activity of Plasmodium falciparum as an Assessment of Parasitemia
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Genome sequence of the human malaria parasite Plasmodium falciparum
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