Journal ArticleDOI
Delivery of siRNA to the brain using a combination of nose-to-brain delivery and cell-penetrating peptide-modified nano-micelles.
TLDR
It is found that MPEG-PCL-Tat accelerated transport along the olfactory and trigeminal nerve pathway because of its high permeation across the nasal mucosa, which improved brain delivery compared to intravenous delivery of dextran either with or without MPEG-CPP, Tat.About:
This article is published in Biomaterials.The article was published on 2013-12-01. It has received 178 citations till now. The article focuses on the topics: Nanoparticles for drug delivery to the brain & Small interfering RNA.read more
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Journal ArticleDOI
Multifunctional polymeric micelles for delivery of drugs and siRNA
TL;DR: The purpose of this review is to highlight recent advances in the development of multifunctional polymeric micelles specifically for delivery of drugs and siRNA, as well as discuss the potential and suitability of multi-functional polymeric mouselles, including lipid-based micella, as promising vehicles for both siRNA and drugs.
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PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application.
TL;DR: This review discusses state‐of‐the‐art nanomedicines based on PEG‐PCL that have been investigated in a preclinical setting and highlights recent therapeutic applications investigated in vitro and in vivo using advanced systems such as triggered release, multi‐component therapies, theranostics, or gene delivery systems.
Journal ArticleDOI
Antisense oligonucleotides in therapy for neurodegenerative disorders.
TL;DR: There has been a recent revival of interest in the use of antisense oligonucleotides to treat several neurodegenerative disorders using different approaches to prevent disease onset or halt disease progression and the first clinical trials for spinal muscular atrophy and amyotrophic lateral sclerosis showing promising results.
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Progress in brain targeting drug delivery system by nasal route.
TL;DR: This review aims to describe the latest development of brain targeted DDSs via nasal administration that directly delivers the drugs to brain without systemic absorption, thus avoiding the side effects and enhancing the efficacy of neurotherapeutics.
Journal ArticleDOI
Oligonucleotide Therapies: The Past and the Present.
TL;DR: This review addresses the development of oligonucleotide (ON) medicines from a historical perspective by listing the landmark discoveries in this field by discussing the various biological processes that have been targeted and the corresponding ON interventions found in the literature.
References
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Journal ArticleDOI
PEGylated Nanoparticles for Biological and Pharmaceutical Applications
TL;DR: The potential utility of multimolecular assembly derived from heterobifunctional PEGs and block copolymers were explored to systematically modify the properties of metal and semiconductor nanostructures by controlling their structure and their surface properties, making them extremely attractive for use in biological and biomedical applications.
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Sniffing neuropeptides: a transnasal approach to the human brain
TL;DR: Three peptides were administered intranasally and found that they achieved direct access to the cerebrospinal fluid (CSF) within 30 minutes, bypassing the bloodstream.
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Nanoparticulate systems for brain delivery of drugs.
TL;DR: Intravenously injected doxorubicin-loaded polysorbate 80-coated nanoparticles were able to lead to a 40% cure in rats with intracranially transplanted glioblastomas 101/8, and may be especially helpful for the treatment of the disseminated and very aggressive brain tumors.
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Intranasal delivery to the central nervous system: Mechanisms and experimental considerations
TL;DR: This review focuses on the current understanding of the mechanisms underlying intranasal delivery to the central nervous system involving the olfactory and trigeminal nerves, the vasculature, the cerebrospinal fluid, and the lymphatic system.