Dengue virus–induced hemorrhage in a nonhuman primate model
Nattawat Onlamoon,Sansanee Noisakran,Sansanee Noisakran,Hui Mien Hsiao,Alexander Duncan,Francois Villinger,Francois Villinger,Aftab A. Ansari,Guey Chuen Perng +8 more
TLDR
Rhesus macaques inoculated intravenously with a high dose of d Dengue virus produced dengue hemorrhage, which may provide a unique platform to define the early events in dengingue virus infection and help identify which blood components contribute to the pathogenesis of denge disease.About:
This article is published in Blood.The article was published on 2010-03-04 and is currently open access. It has received 154 citations till now. The article focuses on the topics: Dengue virus & Dengue fever.read more
Citations
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Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis.
TL;DR: The immune role of platelets is a delicate balance between its pathogenic response and its regulation of thrombotic and hemostatic functions, which regulates hemostasis andThrombosis, infection, and innate and adaptive immunity.
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Fever from the forest: prospects for the continued emergence of sylvatic dengue virus and its impact on public health.
Nikos Vasilakis,Jane Cardosa,Kathryn A. Hanley,Edward C. Holmes,Edward C. Holmes,Scott C. Weaver +5 more
TL;DR: An overview of the ecology and molecular evolution of sylvatic DENV and its potential for adaptation to human transmission is provided and how the study of SylvaticDENV will improve the ability to understand, predict and, ideally, avert further DENV emergence is emphasized.
Journal ArticleDOI
Pathogenesis of the Viral Hemorrhagic Fevers
TL;DR: Although ineffective immunity and high viral loads are characteristic of several viral hemorrhagic fevers, severe plasma leakage occurs at the time of viral clearance and defervescence in dengue hemorrhagic fever.
Journal ArticleDOI
Rapid and massive virus specific plasmablast responses during acute dengue virus infection in humans
Jens Wrammert,Nattawat Onlamoon,Rama Akondy,Guey Chuen Perng,Korakot Polsrila,Anmol Chandele,Marcin Kwissa,Bali Pulendran,Patrick C. Wilson,Orasri Wittawatmongkol,Sutee Yoksan,Nasikarn Angkasekwinai,Kovit Pattanapanyasat,Kulkanya Chokephaibulkit,Rafi Ahmed +14 more
TL;DR: Very potent plasmablast responses that often increased more than 1,000-fold over the baseline levels in healthy volunteers are found, raising the question as to whether these cells might have a role in dengue immunopathology during the ongoing infection.
Journal ArticleDOI
Dengue Virus Infection Induces Expansion of a CD14+CD16+ Monocyte Population that Stimulates Plasmablast Differentiation
Marcin Kwissa,Helder I. Nakaya,Helder I. Nakaya,Nattawat Onlamoon,Jens Wrammert,Jens Wrammert,Francois Villinger,Guey Chuen Perng,Sutee Yoksan,Kovit Pattanapanyasat,Kulkanya Chokephaibulkit,Rafi Ahmed,Rafi Ahmed,Bali Pulendran,Bali Pulendran +14 more
TL;DR: A systems biological approach to analyze immune responses to dengue in humans revealed that genes encoding proinflammatory mediators and type I interferon-related proteins were associated with high DENV levels during initial symptomatic disease and CD14(+)CD16(+) monocytes increased in the blood.
References
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Dengue and Dengue Hemorrhagic Fever
TL;DR: A review of the changing epidemiology of dengue and hemorrhagic fever by geographic region, the natural history and transmission cycles, clinical diagnosis of both Dengue fever and DVF, serologic and virologic laboratory diagnoses, pathogenesis, surveillance, prevention, and control can be found in this paper.
Dengue and dengue hemorrhagic fever.
TL;DR: A major challenge for public health officials in all tropical areas of the world is to devleop and implement sustainable prevention and control programs that will reverse the trend of emergent dengue hemorrhagic fever.
Journal ArticleDOI
Guide for the Care and Use of Laboratory Animals
TL;DR: The Guide for the Care and Use of Laboratory Animals by the Institute for Laboratory Animal Research (ILAR) of the National Research Council in the USA, is well known among most individuals involved in laboratory animal care and use and the overall intention is to support the readers to build a programme which creates a system of selfregulation and regulatory oversight.
Journal ArticleDOI
Pathogenesis of dengue: challenges to molecular biology
TL;DR: This work has identified a severe syndrome, dengue hemorrhagic fever/dengue shock syndrome, in Southeast Asian children, which recently has also been identified in children infected with the virus in Puerto Rico.
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