Journal ArticleDOI
Depressive symptoms increase the risk of progression to dementia in subjects with mild cognitive impairment: systematic review and meta-analysis
Raimundo J. Mourao,Guilherme Mansur,Leandro Fernandes Malloy-Diniz,Erico Costa,Breno S. Diniz,Breno S. Diniz +5 more
TLDR
A meta‐analysis of studies that evaluated the risk of dementia in subjects with MCI and depressive symptoms compared with subjects withMCI and no depressive symptoms concludes that depressive symptoms in older with mild cognitive impairment should be considered as a risk factor for dementia.Abstract:
Objective
There is a long-standing debate in the literature whether depressive symptoms increase the risk of dementia in older with mild cognitive impairment (MCI). We aim to conduct a meta-analysis of studies that evaluated the risk of dementia in subjects with MCI and depressive symptoms compared with subjects with MCI and no depressive symptoms.
Methods
We calculated the relative risk of progression to dementia in subjects with MCI and depressive symptoms compared with subjects with MCI and no depressive symptoms using a generic inverse variance method with random effect models.
Results
Eighteen studies were included in the meta-analysis, with a sample size of 10,861 MCI subjects. The pooled relative risk of progressing to dementia was 1.28 CI95% [1.09–1.52] (p = 0.003) in the group of MCI subjects with depressive symptoms compared with the MCI subjects with no depressive symptoms.
Discussion
Our results provide additional evidence that depressive symptoms determine an additive risk effect to the progression to dementia in subjects with MCI. The comorbidity between depression and cognitive impairment can be an intervention target for prevention of dementia in MCI subjects. Copyright © 2015 John Wiley & Sons, Ltd.read more
Citations
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Journal ArticleDOI
Prevalence of Depression in Patients With Mild Cognitive Impairment: A Systematic Review and Meta-analysis.
Zahinoor Ismail,Heba Elbayoumi,Corinne E. Fischer,David B. Hogan,Colleen Millikin,Tom A. Schweizer,Moyra E. Mortby,Eric E. Smith,Scott B. Patten,Kirsten M. Fiest +9 more
TL;DR: The method used to diagnose depression did not significantly influence the prevalence estimate, nor did the criteria used for MCI diagnosis or MCI subtype, and a contributor to heterogeneity in the reported literature is the source of the sample, with greater depression burden prevalent in clinic-based samples.
Journal ArticleDOI
Implications of sleep disturbance and inflammation for Alzheimer's disease dementia
TL;DR: A bidirectional relationship between sleep and Alzheimer's disease is supported by advances in understanding of sleep disturbance-induced increases in systemic inflammation, which can be viewed as an early event in the course of Alzheimer’s disease.
Journal ArticleDOI
Vascular depression consensus report - a critical update.
Howard J. Aizenstein,Andrius Baskys,Maura Boldrini,Meryl A. Butters,Breno S. Diniz,Manoj Kumar Jaiswal,Kurt A. Jellinger,Lev S. Kruglov,Ivan A. Meshandin,Milija Mijajlovic,Guenter Niklewski,Sarah Pospos,Keerthy Raju,Kneginja Richter,David C. Steffens,Warren D. Taylor,Warren D. Taylor,Oren Tene +17 more
TL;DR: This diagnosis, based on clinical and MRI findings, suggests that vascular lesions lead to depression by disruption of frontal–subcortical–limbic networks involved in mood regulation, and should be reserved for depressed older patients with vascular pathology and evident cerebral involvement.
Journal ArticleDOI
Epilepsy and cognition - A bidirectional relationship?
TL;DR: In conclusion, an epilepsy-centric unidirectional view of the behavioral problems being caused by epilepsy is obsolete and a practical clinical approach is favored according to which the comorbidities of epilepsy must be diagnosed at the onset of the disease, and according to who may require separate treatment approaches.
Journal ArticleDOI
Vitamin D and Depression: Cellular and Regulatory Mechanisms
TL;DR: The phenotypic stability hypothesis argues that vitamin D acts by reducing the increased neuronal levels of Ca2+ that are driving depression, which may explain how it acts to reduce the onset of depression.
References
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Journal ArticleDOI
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TL;DR: Moher et al. as mentioned in this paper introduce PRISMA, an update of the QUOROM guidelines for reporting systematic reviews and meta-analyses, which is used in this paper.
Journal ArticleDOI
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Guy M. McKhann,David A. Drachman,Marshall F. Folstein,Robert Katzman,Donald L. Price,Emanuel M. Stadlan +5 more
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Journal ArticleDOI
Mild Cognitive Impairment: Clinical Characterization and Outcome
Ronald C. Petersen,Glenn E. Smith,Stephen C. Waring,Robert J. Ivnik,Eric G. Tangalos,Emre Kokmen +5 more
TL;DR: Patients who meet the criteria for MCI can be differentiated from healthy control subjects and those with very mild AD, and appear to constitute a clinical entity that can be characterized for treatment interventions.
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