Journal ArticleDOI
Prevalence of Depression in Patients With Mild Cognitive Impairment: A Systematic Review and Meta-analysis.
Zahinoor Ismail,Heba Elbayoumi,Corinne E. Fischer,David B. Hogan,Colleen Millikin,Tom A. Schweizer,Moyra E. Mortby,Eric E. Smith,Scott B. Patten,Kirsten M. Fiest +9 more
TLDR
The method used to diagnose depression did not significantly influence the prevalence estimate, nor did the criteria used for MCI diagnosis or MCI subtype, and a contributor to heterogeneity in the reported literature is the source of the sample, with greater depression burden prevalent in clinic-based samples.Abstract:
Importance Depression is common in individuals with mild cognitive impairment (MCI) and may confer a higher likelihood of progression to dementia. Prevalence estimates of depression in those with MCI are required to guide both clinical decisions and public health policy, but published results are variable and lack precision. Objective To provide a precise estimate of the prevalence of depression in individuals with MCI and identify reasons for heterogeneity in the reported results. Data sources A search of literature from database inception to March 2016 was performed using Medline, Embase, and PsycINFO. Hand searching of all included articles was performed, including a Google Scholar search of citations of included articles. Study selection Articles were included if they (1) were published in English, (2) reported patients with MCI as a primary study group, (3) reported depression or depressive symptoms using a validated instrument, and (4) reported the prevalence of depression in patients with MCI. Data extraction and synthesis All abstracts, full-text articles, and other sources were reviewed, with data extracted in duplicate. The overall prevalence of depression in patients with MCI was pooled using a random-effects model. Heterogeneity was explored using stratification and random-effects meta-regression. Main outcomes and measures The prevalence of depression in patients with MCI, reported as a percentage with 95% CIs. Estimates were also stratified by population source (community-based or clinic-based sample), method of depression diagnosis (clinician-administered, informant-based, or self-report), and method of MCI diagnosis (cognitive vs global measure and amnestic vs nonamnestic). Results Of 5687 unique abstracts, 255 were selected for full-text review, and 57 studies, representing 20 892 patients, met all inclusion criteria. The overall pooled prevalence of depression in patients with MCI was 32% (95% CI, 27-37), with significant heterogeneity between estimates (I2 = 90.7%). When stratified by source, the prevalence of depression in patients with MCI in community-based samples was 25% (95% CI, 19-30) and was 40% (95% CI, 32-48) in clinic-based samples, which was significantly different (P Conclusions and relevance The prevalence of depression in patients with MCI is high. A contributor to heterogeneity in the reported literature is the source of the sample, with greater depression burden prevalent in clinic-based samples.read more
Citations
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Journal ArticleDOI
Prevalence of depression and depressive symptoms among outpatients: a systematic review and meta-analysis
Jinghui Wang,Xiaohang Wu,Weiyi Lai,Erping Long,Xiayin Zhang,Wangting Li,Yi Zhu,Chuan Chen,Xiaojian Zhong,Zhenzhen Liu,Dongni Wang,Haotian Lin +11 more
TL;DR: Evidence is provided that a significant proportion of outpat patients experience depression or depressive symptoms, highlighting the importance of developing effective management strategies for the early identification and treatment of these conditions among outpatients in clinical practice.
Journal ArticleDOI
The Mild Behavioral Impairment Checklist (MBI-C): A Rating Scale for Neuropsychiatric Symptoms in Pre-Dementia Populations
Zahinoor Ismail,Luis Agüera-Ortiz,Henry Brodaty,Alicja Cieslak,Jeffrey L. Cummings,Corinne E. Fischer,Serge Gauthier,Yonas E. Geda,Nathan Herrmann,Jamila Kanji,Krista L. Lanctôt,David Miller,Moyra E. Mortby,Chiadi U. Onyike,Paul B. Rosenberg,Eric E. Smith,Gwenn S. Smith,David L. Sultzer,Constantine G. Lyketsos +18 more
TL;DR: The MBI-C provides the first measure specifically developed to assess the MBI construct as explicitly described in the criteria, and its utility lies in MBI case detection, and monitoring the emergence of MBI symptoms and domains over time.
Journal ArticleDOI
Bifidobacterium with the role of 5-hydroxytryptophan synthesis regulation alleviates the symptom of depression and related microbiota dysbiosis.
TL;DR: Results indicate that Bifidobacterium E41 and M2CF22M7 have an antidepressant effect in mice partly in a 5-HTP dependent and microbiota-regulating manner, and Nurturing the gut microbiota with these strains may become an emerging therapeutic way for mood disorder.
Journal ArticleDOI
Arcsine-based transformations for meta-analysis of proportions: Pros, cons, and alternatives
Lifeng Lin,Chang Xu +1 more
TL;DR: The pros and cons of arcsine‐based transformations are explained, the alternatives that may be generally superior to the currently popular practice are discussed, and generalized linear mixed models and Bayesian models are discussed.
Journal ArticleDOI
Affective and emotional dysregulation as pre-dementia risk markers: exploring the mild behavioral impairment symptoms of depression, anxiety, irritability, and euphoria.
Zahinoor Ismail,Jennifer R. Gatchel,Daniel R. Bateman,Ricardo Barcelos-Ferreira,Marc Cantillon,Judith Jaeger,Nancy J. Donovan,Moyra E. Mortby +7 more
TL;DR: Affective symptoms are of prognostic utility, but interventions to prevent dementia syndromes are limited, and trials need to assess interventions targeting known dementia pathology, toward novel pathology, as well as using psychiatric medications.
References
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Journal ArticleDOI
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