Journal ArticleDOI
Design and therapeutic application of matrix metalloproteinase inhibitors.
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This article is published in Chemical Reviews.The article was published on 1999-09-08. It has received 944 citations till now. The article focuses on the topics: Matrix metalloproteinase inhibitor.read more
Citations
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Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy.
Richard A. Friesner,Jay L. Banks,Robert B. Murphy,Thomas A. Halgren,Jasna Klicic,Daniel T. Mainz,Matthew P. Repasky,Eric H. Knoll,Mee Shelley,Jason K. Perry,David E. Shaw,Perry Francis,Peter S Shenkin +12 more
TL;DR: Glide approximates a complete systematic search of the conformational, orientational, and positional space of the docked ligand to find the best docked pose using a model energy function that combines empirical and force-field-based terms.
Journal ArticleDOI
Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening.
Thomas A. Halgren,Robert B. Murphy,Richard A. Friesner,Hege S. Beard,Leah L. Frye,W. Thomas Pollard,Jay L. Banks +6 more
TL;DR: Comparisons to results for the thymidine kinase and estrogen receptors published by Rognan and co-workers show that Glide 2.5 performs better than GOLD 1.1, FlexX 1.8, or DOCK 4.01.
Journal ArticleDOI
Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations
TL;DR: The studies that brought MPIs into clinical testing are reviewed and the design and outcome of the trials are discussed in light of new information about the cellular source, substrates, and mode of action of MMPs at different stages of tumor progression.
Journal ArticleDOI
Iron-Catalyzed Reactions in Organic Synthesis
TL;DR: A new iron(III) halide-promoted aza-Prins cyclization between γ,δ-unsaturated tosylamines and aldehydes provides six-membered azacycles in good to excellent yields.
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Asymmetric multicomponent reactions (amcrs): the new frontier
Diego J. Ramón,Miguel Yus +1 more
TL;DR: Asymmetric multicomponent reactions involve the preparation of chiral compounds by the reaction of three or more reagents added simultaneously and has some advantages over classic divergent reaction strategies, such as lower costs, time, and energy, as well as environmentally friendlier aspects.
References
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Journal ArticleDOI
A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
Roy A. Black,Charles Rauch,Carl J. Kozlosky,Jacques J. Peschon,Jennifer L. Slack,Martin F. Wolfson,Beverly J. Castner,Kim L. Stocking,Pranitha Reddy,Subhashini Srinivasan,Nicole Nelson,Norman Boiani,Kenneth A. Schooley,Mary Gerhart,Raymond Davis,Jeffrey N. Fitzner,Richard S. Johnson,Raymond J. Paxton,Carl J. March,Douglas P. Cerretti +19 more
TL;DR: The results should facilitate the development of therapeutically useful inhibitors of TNF-α release, and they indicate that an important function of adamalysins may be to shed cell-surface proteins.
Journal ArticleDOI
A matrix metalloproteinase expressed on the surface of invasive tumour cells
Hiroshi Sato,Takahisa Takino,Yasunori Okada,Jian Cao,Akira Shinagawa,Etsuhide Yamamoto,Motoharu Seiki +6 more
TL;DR: The cloning of the complemen-tary DNA encoding a new matrix metalloproteinase with a potential transmembrane domain is reported, which may trigger invasion by tumour cells by activating pro-gelatinase A on the tumour cell surface.
Journal ArticleDOI
Discovering High-Affinity Ligands for Proteins: SAR by NMR
TL;DR: A nuclear magnetic resonance (NMR)-based method is described in which small organic molecules that bind to proximal subsites of a protein are identified, optimized, and linked together to produce high-affinity ligands and appears particularly useful in target-directed drug research.
Journal ArticleDOI
Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase ISOLATION OF THE ACTIVATED FORM OF THE MEMBRANE METALLOPROTEASE
Alex Y. Strongin,Ivan E. Collier,Gregory A. Bannikov,Barry L. Marmer,Gregory A. Grant,Gregory I. Goldberg +5 more
TL;DR: Activation of 72T4Cl on the cell membrane provides a basic mechanism for spatially regulated extracellular proteolysis and presents a new target for prognosis and treatment of metastatic disease.
Journal ArticleDOI
Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha.
Marcia L. Moss,S.-L. Catherine Jin,Marcos E. Milla,William Burkhart,H. Luke Carter,Wen-Ji Chen,William C. Clay,John R. Didsbury,Daniel F. Hassler,Christine R. Hoffman,Thomas A. Kost,Millard H. Lambert,M. Anthony Leesnitzer,Philip McCauley,Gerard McGeehan,Justin L. Mitchell,Mary Pat Moyer,Gregory Pahel,Warren J. Rocque,Laurie K. Overton,Frank J Schoenen,Theresa D. Seaton,Jui-Lan Su,Janet Warner,Derril H. Willard,J. David Becherer +25 more
TL;DR: The expression of recombinant TACE results in the production of functional enzyme that correctly processes precursor TNF-α to the mature form, and provides a readily available source of enzyme to help in the search for new anti-inflammatory agents that target the final processing stage of T NF-α production.
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