Journal ArticleDOI
Development of Biodegradable and Injectable Latices for Controlled Release of Potent Drugs
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A new dosage form designed to provide parenteral drug delivery over a prolonged period of time following a standard injection using testosterone as the model drug consists of a biodegradable, biocompatible polymer in which the drug is dispersed on a molecular level.Abstract:
A new dosage form designed to provide parenteral drug delivery over a prolonged period of time following a standard injection has been investigated using testosterone as the model drug. The drug carrier consists of a biodegradable, biocompatible polymer in which the drug is dispersed on a molecular level. The polymer itself is formulated as a pseudolatex with high solid content (40.0%). The formulation has a low viscosity (97 cps) which can be injected easily through a hypodermic needle. The histopathology study showed good tissue compatibility of the pseudolatices and in-vivo tests on rats confirmed a prolonged release of drug over a 14 day period. The stability of the biodegradable poly-d, l-lactic acid latex was found not to be significantly changed over 120 days of storage at room temperature (25°). A six month study showed a slight increase (10%) in the viscosity of the parenteral product when stored at room temperature. The increase was attributed to partial coalescence of the polymer partic...read more
Citations
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Strategies in the design of nanoparticles for therapeutic applications
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Polymer nanoparticles: Preparation techniques and size-control parameters
J. Prasad Rao,Kurt E. Geckeler +1 more
TL;DR: In this paper, a review of the preparation of polymer nanoparticles and the crucial parameters involved in techniques designed to obtain the desired properties is presented, and the choice of method depends on a number of factors, such as particle size, particle size distribution, area of application, etc.
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Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles.
TL;DR: In this review the most important preparation methods are described, especially those that make use of natural polymers, andvantages and disadvantages will be presented so as to facilitate selection of an appropriate nanoencapsulation method according to a particular application.
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Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach.
TL;DR: Vaccines are certainly the most promising applications for orally delivered nanoparticles and encouraging results upon in vivo testing are reported but low bioavailability and lack of control on absorbed dose slow down products development.
Journal ArticleDOI
Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery
TL;DR: This review will focus on the nature of the polymers involved in the preparation of targeted nanocarriers, the synthesis methods to achieve the desired macromolecular architecture, the selected coupling strategy, and the choice of the homing molecules (vitamins, hormones, peptides, proteins, etc.), as well as the various strategies to display them at the surface of nanoccarriers.
References
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Manual of histologic staining methods of the Armed forces institute of pathology
TL;DR: This work states that stem cells: mechanisms of inflammation,” Annual Review of Pathology, vol.
Journal ArticleDOI
Degradation rates of oral resorbable implants (polylactates and polyglycolates): Rate modification with changes in PLA/PGA copolymer ratios
TL;DR: Control of degradation rate of the implant could best be attained by varying the composition of PLA and PGA between 75% and 100% PLA along with a corresponding 25% to 0% PGA.
Journal ArticleDOI
Biodegradable poly(lactic acid) polymers
TL;DR: A biological in vitro method for determining the degradation of poly(lactic acids) indicates, in accordance with expectations, that poly(dl-lactic acid) degrades at a faster rate than L(+) lactic acid.
Journal ArticleDOI
Polylactic Acid for Surgical Implants
TL;DR: The material is expected to elicit no immunological response due to the absence of peptide linkages, and make this a highly interesting product as a synthetic surgical repair material possibly for vascular grafts and sutures.