Journal ArticleDOI
Development of copper(II)-diimine-iminodiacetate mixed ligand complexes as potential antitumor agents
Natalia Alvarez,Luis F.S. Mendes,M. Gabriela Kramer,María H. Torre,Antonio J. Costa-Filho,Javier Ellena,Gianella Facchin +6 more
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TLDR
In this article, the synthesis and characterization of eight compounds with general formula [Cu(iminodiacetate)(diimine)(H2O)x], with x = 0 or 1, and their cytotoxic activities against tumor cells were presented.About:
This article is published in Inorganica Chimica Acta.The article was published on 2018-11-01. It has received 55 citations till now. The article focuses on the topics: Diimine & Ligand.read more
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Structures, spectra, and DNA-binding properties of mixed ligand copper(II) complexes of iminodiacetic acid: The novel role of diimine co-ligands on DNA conformation and hydrolytic and oxidative double strand DNA cleavage
Balaraman Selvakumar,Venugopal Rajendiran,Palanisamy Uma Maheswari,Helen Stoeckli-Evans,Mallayan Palaniandavar +4 more
TL;DR: The coordination geometry around copper(II) in [Cu(imda)(phen)(H 2 O)] is described as distorted octahedral while those in this paper are described as trigonal bipyramidal distorted square-based pyramidal with the imda anion facially coordinated to copper (II) and viscosity measurements indicate that 3 interacts with calf thymus DNA more strongly than 1 and 2.
Journal ArticleDOI
Synthesis and crystal structures of cytotoxic mixed-ligand copper(II) complexes with alkyl tetrazole and polypyridine derivatives
Julia A. Eremina,Elizaveta V. Lider,Natalia V. Kuratieva,Denis G. Samsonenko,Lyubov S. Klyushova,Dmitriy G. Sheven,R. E. Trifonov,Vladimir A. Ostrovskii +7 more
TL;DR: A series of mixed-ligand copper(II) complexes has been synthesized and the complexes have been characterized by elemental analysis, IR spectroscopy and powder X-ray diffraction as mentioned in this paper.
Journal ArticleDOI
Water-soluble copper(II) complexes with 4,5-dichloro-isothiazole-3-carboxylic acid and heterocyclic N-donor ligands: Synthesis, crystal structures, cytotoxicity, and DNA binding study
Julia A. Eremina,Elizaveta V. Lider,Taisiya S. Sukhikh,Lyubov S. Klyushova,M. L. Perepechaeva,Dmitriy G. Sheven,Alexey S. Berezin,Alevtina Y. Grishanova,Vladimir I. Potkin +8 more
TL;DR: In this paper, four new water-soluble copper(II) complexes [Cu(dmbipy)L2], [cu(phen)(H2O)L 2], [Cu (dmphen)LII] and [Cu2(bipy)-2L4] have been characterized by elemental and powder X-ray diffraction analysis.
Journal ArticleDOI
Synthesis and structural characterization of a series of ternary copper(II)-L-dipeptide-neocuproine complexes. Study of their cytotoxicity against cancer cells including MDA-MB-231, triple negative breast cancer cells.
Natalia Alvarez,Diana Viña,Celisnolia M. Leite,Luis F.S. Mendes,Alzir A. Batista,Javier Ellena,Antonio J. Costa-Filho,Gianella Facchin +7 more
TL;DR: The synthesis and characterization of eight copper complexes and their cytotoxic activities against tumor cell lines are suggested to be promising steps towards new effective drugs to treat cancer.
Journal ArticleDOI
Copper-diimine coordination compounds as potential new tools in the treatment of cancer
Natalia Alvarez,M. Gabriela Kramer,Javier Ellena,Antonio José da Costa Filho,María H. Torre,Gianella Facchin +5 more
TL;DR: This paper summarizes the results on the study of Copper-diimine of ternary complexes and related Copper homoleptic complexes as cytotoxic agents and hypothesizes that the cation [Cu( diimine) ]2+ is the active species of the complexes.
References
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Journal ArticleDOI
Crystal structure refinement with SHELXL
TL;DR: New features added to the refinement program SHELXL since 2008 are described and explained.
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WinGX and ORTEP for Windows: an update
TL;DR: The WinGX suite provides a complete set of programs for the treatment of small-molecule single-crystal diffraction data, from data reduction and processing, structure solution, model refinement and visualization, and metric analysis of molecular geometry and crystal packing, to final report preparation in the form of a CIF.
Journal ArticleDOI
Synthesis, structure, and spectroscopic properties of copper(II) compounds containing nitrogen–sulphur donor ligands; the crystal and molecular structure of aqua[1,7-bis(N-methylbenzimidazol-2′-yl)-2,6-dithiaheptane]copper(II) perchlorate
TL;DR: In this article, the linear quadridentate N2S2 donor ligand 1,7-bis(N-methylbenzimidazol-2′-yl)-2,6-dithiaheptane (bmdhp) forms mono-and di-hydrate 1 : 1 copper(II) complexes which are significantly more stable toward autoreduction than those of the non-methylated analogue.
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Mercury: visualization and analysis of crystal structures
Clare F. Macrae,Paul R. Edgington,Patrick McCabe,Elna Pidcock,Greg P. Shields,Robin Taylor,Matthew Towler,Jacco van de Streek +7 more
TL;DR: Mercury as discussed by the authors is a crystal structure visualization program that allows to display multiple structures simultaneously and overlay them, which can be used for comparison between crystal structures and to overlay them in a table or spreadsheets.
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ShelXle: a Qt graphical user interface for SHELXL
TL;DR: ShelXle is a user-friendly graphical user interface forSHELXL that combines an editor with syntax highlighting for SHELXL-associated files with an interactive graphical display for visualization of a three-dimensional structure.