Journal ArticleDOI
Development of monoclonal antibodies against IgM of half-smooth tongue sole (Cynoglossus semilaevis) and analysis of phagocytosis of fluorescence microspheres by mIgM+ lymphocytes.
Reads0
Chats0
TLDR
It is demonstrated that the MAbs produced in this study could specifically recognize the serum IgM and mIgM on B lymphocytes of half‐smooth tongue sole and have the phagocytic capacity, which indicates mIGM+ lymphocyte play important role in innate immune response.About:
This article is published in Fish & Shellfish Immunology.The article was published on 2017-07-01. It has received 33 citations till now. The article focuses on the topics: Immunoglobulin M.read more
Citations
More filters
Journal ArticleDOI
The macrophage-expressed gene (mpeg) 1 identifies a subpopulation of B cells in the adult zebrafish.
Giuliano Ferrero,Etienne Gomez,Sowmya lyer,Mireia Rovira,Magali Miserocchi,David M. Langenau,Julien Y. Bertrand,Valérie Wittamer +7 more
TL;DR: These findings demonstrate that irf8 functions in myelopoiesis are evolutionary conserved and highlight the need for alternative macrophage‐specific markers to study the mononuclear phagocytic system in adult zebrafish.
Journal ArticleDOI
Mucosal immunoglobulins of teleost fish: A decade of advances.
TL;DR: A review of the current status of the field of fish immunoglobulins can be found in this article, where the authors identify knowledge gaps and future avenues to move the field forward in both basic and applied science areas.
Journal ArticleDOI
Recent Advances on Phagocytic B Cells in Teleost Fish.
TL;DR: It is indicated that teleost phagocytic B cells, as well as their counterpart mammalian B1-B cells, can be considered one kind of professional phagocytes, with a particular focus on the recognizing receptors and modulating mechanisms of phagocyte B cells and the process of antigen presentation for T-cell activation.
Journal ArticleDOI
Effects of cell differentiation on the phagocytic activities of IgM+ B cells in a teleost fish
Liting Wu,Linghe Kong,Yanjian Yang,Xia Bian,Siwei Wu,Bingxi Li,Xiaoxue Yin,Liangliang Mu,Jun Li,Jianmin Ye +9 more
TL;DR: The results indicated that B cell differentiation may cause the decrease of phagocytic capacity but notPhagocytosis ability of phAGocytic IgM+ B cells in teleost, which may provide an evolutionary evidence for understanding the greater specialization of the B cell in more sophisticated adaptive humoral immunity.
Journal ArticleDOI
Development of monoclonal antibodies against IgM of sea bass (Lateolabrax japonicus) and analysis of phagocytosis by mIgM+ lymphocytes.
TL;DR: The results demonstrated that the MAbs produced in this paper could be used as tools to study secretory IgM and mIgM + lymphocytes of sea bass, and may also play an important role in innate immunity of seabass.
References
More filters
Journal ArticleDOI
Structure and function of immunoglobulins.
TL;DR: Immunoglobulins are heterodimeric proteins composed of 2 heavy and 2 light chains that can be separated functionally into variable domains that bind antigens and constant domains that specify effector functions, such as activation of complement or binding to Fc receptors.
Journal ArticleDOI
Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts.
Jordi Ochando,Chiho Homma,Yu Yang,Andrés Hidalgo,Alexandre Garin,Frank Tacke,Veronique Angeli,Yansui Li,Peter Boros,Yaozhong Ding,Rolf Jessberger,Rolf Jessberger,Giorgio Trinchieri,Sergio A. Lira,Gwendalyn J. Randolph,Jonathan S. Bromberg +15 more
TL;DR: Plasmacytoid dendritic cells (pDCs) are identified as phagocytic antigen-presenting cells essential for tolerance to vascularized cardiac allografts and home to the lymph nodes in tolerogenic conditions, where they mediate alloantigen-specific Treg cell development andallograft tolerance.
Journal ArticleDOI
Phagocytosis and innate immunity.
TL;DR: This work has revealed a fundamental requirement for two co-ordinated cellular processes--cytoskeletal alterations and membrane trafficking--in the phagocytic event.
Journal ArticleDOI
B lymphocytes from early vertebrates have potent phagocytic and microbicidal abilities.
Jun Li,Daniel R. Barreda,Yong-An Zhang,Hani Boshra,Andrew E. Gelman,Scott E. LaPatra,Lluis Tort,J. Oriol Sunyer +7 more
TL;DR: The findings support the idea that B cells evolved from an ancestral phagocytic cell type and provide an evolutionary framework for understanding the close relationship between mammalian B lymphocytes and macrophages.
Journal ArticleDOI
Comparative analyses of immunoglobulin genes: surprises and portents.
TL;DR: The study of immunoglobulin genes in non-mouse and non-human models has shown that different vertebrate groups have evolved distinct methods of generating antibody diversity, but the development of T cells in the thymus is quite similar in all of the species that have been examined.