Journal ArticleDOI
Diagnostic imaging of breast cancer using fluorescence-enhanced optical tomography: phantom studies.
Anuradha Godavarty,Alan B. Thompson,Ranadhir Roy,Mikhail Gurfinkel,Margaret J. Eppstein,Chaoyang Zhang,Eva M. Sevick-Muraca +6 more
TLDR
These studies represent the first 3-D tomographic images from physiologically relevant geometries for breast imaging from 2-D boundary surface measurements using the modified truncated Newton's method.Abstract:
Molecular targeting with exogenous near-infrared excitable fluorescent agents using time-dependent imaging techniques may enable diagnostic imaging of breast cancer and prognostic imaging of sentinel lymph nodes within the breast. However, prior to the administration of unproven contrast agents, phantom studies on clinically relevant volumes are essential to assess the benefits of fluorescence-enhanced optical imaging in humans. Diagnostic 3-D fluorescence-enhanced optical tomography is demonstrated using 0.5 to 1 cm(3) single and multiple targets differentiated from their surroundings by indocyanine green (micromolar) in a breast-shaped phantom (10-cm diameter). Fluorescence measurements of referenced ac intensity and phase shift were acquired in response to point illumination measurement geometry using a homodyned intensified charge-coupled device system modulated at 100 MHz. Bayesian reconstructions show artifact-free 3-D images (3857 unknowns) from 3-D boundary surface measurements (126 to 439). In a reflectance geometry appropriate for prognostic imaging of lymph node involvement, fluorescence measurements were likewise acquired from the surface of a semi-infinite phantom (8x8x8 cm(3)) in response to area illumination (12 cm(2)) by excitation light. Tomographic 3-D reconstructions (24,123 unknowns) were recovered from 2-D boundary surface measurements (3194) using the modified truncated Newton's method. These studies represent the first 3-D tomographic images from physiologically relevant geometries for breast imaging.read more
Citations
More filters
Book ChapterDOI
Introduction to the Finite Element Method
Nathan Ida,João P. A. Bastos +1 more
TL;DR: This chapter introduces the finite element method (FEM) as a tool for solution of classical electromagnetic problems and discusses the main points in the application to electromagnetic design, including formulation and implementation.
Journal ArticleDOI
Recent advances in diffuse optical imaging.
TL;DR: The current state-of-the-art of diffuse optical imaging is reviewed, which is an emerging technique for functional imaging of biological tissue and recent work on in vivo applications including imaging the breast and brain is reviewed.
Journal ArticleDOI
Three-dimensional in vivo fluorescence diffuse optical tomography of breast cancer in humans.
Alper Corlu,Regine Choe,Turgut Durduran,Mark A. Rosen,Martin Schweiger,Simon R. Arridge,Mitchell D. Schnall,Arjun G. Yodh +7 more
TL;DR: This work represents the first reported 3D fluorescence tomography of human breast cancer in vivo based on fluorescence diffuse optical tomography (FDOT), and the measurements demonstrate that FDOT of breast cancer is feasible and promising.
Journal ArticleDOI
Image-guided diffuse optical fluorescence tomography implemented with Laplacian-type regularization.
TL;DR: A promising method to incorporate tissue structural information into the reconstruction of diffusion-based fluorescence imaging is introduced, which regularizes the inversion problem with a Laplacian-type matrix, which inherently smoothes pre-defined tissue, but allows discontinuities between adjacent regions.
Journal ArticleDOI
Magnetic resonance-coupled fluorescence tomography scanner for molecular imaging of tissue.
Scott C. Davis,Brian W. Pogue,Roger Springett,Christoph Leussler,Mazurkewitz Peter M,Stephen B. Tuttle,Summer L. Gibbs-Strauss,Shudong Jiang,Hamid Dehghani,Hamid Dehghani,Keith D. Paulsen +10 more
TL;DR: A multichannel spectrally resolved optical tomography system to image molecular targets in small animals from within a clinical MRI is described, and recovered values of indocyanine green fluorescence yield are linear to concentrations of 1 nM in a 70 mm diameter homogeneous phantom, and detection is feasible to near 10 pM.
References
More filters
Book
The finite element method in engineering science
TL;DR: In this paper, the authors describe how people search numerous times for their favorite books like this the finite element method in engineering science, but end up in malicious downloads, and instead they cope with some infectious bugs inside their computer.
Book
An Introduction to the Finite Element Method
TL;DR: Second-order Differential Equations in One Dimension: Finite Element Models (FEM) as discussed by the authors is a generalization of the second-order differential equation in two dimensions.
Book ChapterDOI
Introduction to the Finite Element Method
Nathan Ida,João P. A. Bastos +1 more
TL;DR: This chapter introduces the finite element method (FEM) as a tool for solution of classical electromagnetic problems and discusses the main points in the application to electromagnetic design, including formulation and implementation.
Journal Article
Boundary-conditions for the diffusion equation in radiative-transfer
TL;DR: In this article, Haskell et al. proposed a boundary condition for the diffusion equation in radiative transfer, which is based on the partial-current and extrapolated boundary conditions, which are commonly applied to the surface of a semi-infinite turbid medium.
Journal ArticleDOI
Boundary conditions for the diffusion equation in radiative transfer
Richard C. Haskell,Lars O. Svaasand,Tsong-Tseh Tsay,Ti-Chen Feng,Matthew S. McAdams,Bruce J. Tromberg +5 more
TL;DR: It is concluded that noninvasive measurements of optically thick tissue require a rigorous treatment of the tissue boundary, and a unified partial-current--extrapolated boundary approach is suggested.