Diagnostic performance of a multiplex PCR assay for meningitis in an HIV-infected population in Uganda
Joshua Rhein,Joshua Rhein,Nathan C. Bahr,Andrew Hemmert,Joann L. Cloud,Satya Bellamkonda,Cody Oswald,Eric Lo,Henry W. Nabeta,Reuben Kiggundu,Andrew Akampurira,Abdu K Musubire,Abdu K Musubire,Darlisha A. Williams,Darlisha A. Williams,David B. Meya,David B. Meya,David R. Boulware +17 more
TLDR
The FilmArray Meningitis/Encephalitis panel offers a promising platform for rapid meningitis diagnosis and differentiated between fungal relapse and paradoxical immune reconstitution inflammatory syndrome in recurrent episodes.About:
This article is published in Diagnostic Microbiology and Infectious Disease.The article was published on 2016-03-01 and is currently open access. It has received 93 citations till now. The article focuses on the topics: Meningitis & Immune reconstitution inflammatory syndrome.read more
Citations
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Journal ArticleDOI
Multicenter Evaluation of BioFire FilmArray Meningitis/Encephalitis Panel for Detection of Bacteria, Viruses, and Yeast in Cerebrospinal Fluid Specimens
Amy Leber,Kathy Everhart,Joan-Miquel Balada-Llasat,Jillian Cullison,Judy A. Daly,Sarah Holt,Paul R. Lephart,Hossein Salimnia,Paul C. Schreckenberger,Sharon DesJarlais,Sharon L. Reed,Kimberle C. Chapin,Lindsay LeBlanc,J. Kristie Johnson,Nicole L. Soliven,Karen C. Carroll,Jo Anne Miller,Jennifer Dien Bard,Javier Mestas,Matthew J. Bankowski,Matthew J. Bankowski,Tori Enomoto,Andrew C. Hemmert,Kevin M. Bourzac +23 more
TL;DR: The FilmArray Meningitis/Encephalitis (ME) Panel is a sensitive and specific test to aid in diagnosis of ME and improved patient outcomes and antimicrobial stewardship are anticipated.
Journal ArticleDOI
Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults: a prospective cohort study.
Nathan C. Bahr,Nathan C. Bahr,Edwin Nuwagira,Emily E Evans,Fiona V Cresswell,Fiona V Cresswell,Philip V Bystrom,Adolf Byamukama,Sarah C Bridge,Sarah C Bridge,Ananta S Bangdiwala,David B. Meya,David B. Meya,Claudia M. Denkinger,Conrad Muzoora,David R. Boulware,Darlisha A. Williams,Kabanda Taseera,Dan Nyehangane,Mugisha Ivan,Patrick Orikiriza,Joshua Rhein,Katherine Huppler Hullsiek,Abdu K Musubire,Katelyn A Pastick,Pamela Nabeta,James Mwesigye,Radha Rajasingham +27 more
TL;DR: World Health Organization (WHO) recommends the use of Xpert Ultra as the initial diagnostic test for suspected tuberculous meningitis, following an evaluation of the diagnostic performance of the new Xpert MTB/RIF Ultra (Xpert Ultra).
Journal ArticleDOI
Syndromic Panel-Based Testing in Clinical Microbiology
TL;DR: This review focuses on U.S. Food and Drug Administration-approved/cleared multiplex molecular panels with more than five targets designed to assist in the diagnosis of bloodstream, respiratory tract, gastrointestinal, or central nervous system infections.
Journal ArticleDOI
The UK joint specialist societies guideline on the diagnosis and management of acute meningitis and meningococcal sepsis in immunocompetent adults
Fiona McGill,Robert S. Heyderman,Benedict D Michael,Benedict D Michael,Sylviane Defres,Sylviane Defres,Sylviane Defres,Nicholas J. Beeching,Ray Borrow,Linda Glennie,O Gaillemin,Duncan Wyncoll,Edward B. Kaczmarski,Simon Nadel,Simon Nadel,Guy E. Thwaites,Jonathan Cohen,N. W.S. Davies,Alastair Miller,Andrew Rhodes,Robert C. Read,Robert C. Read,Tom Solomon +22 more
TL;DR: Revised guidelines for the management of immunocompetent adults with meningitis and meningococcal sepsis in adults, which for the first time include viralMeningitis, are written in accordance with the AGREE 2 tool and recommendations graded according to the GRADE system.
Journal ArticleDOI
Diagnostic test accuracy of the BioFire® FilmArray® meningitis/encephalitis panel: a systematic review and meta-analysis.
TL;DR: The currently available literature suggests that the ME panel has high diagnostic accuracy, however, the decision for implementation should be individualized based on the needs of the patient population, the capabilities of the laboratory, and the knowledge of the healthcare providers that will utilize the test.
References
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Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS.
Benjamin J. Park,Kathleen Wannemuehler,Barbara J. Marston,Nelesh P. Govender,Peter G. Pappas,Tom Chiller +5 more
TL;DR: The first attempt to estimate the global burden of cryptococcal meningitis finds the number of cases and deaths to be very high, with most occurring in sub-Saharan Africa.
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Randomized placebo-controlled trial of prednisone for paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome
Graeme Meintjes,Robert J. Wilkinson,Chelsea Morroni,Dominique J. Pepper,Kevin Rebe,Molebogeng X Rangaka,Tolu Oni,Gary Maartens +7 more
TL;DR: Prednisone reduced the need for hospitalization and therapeutic procedures and hastened improvements in symptoms, performance, and quality of life while investigating for drug-resistant tuberculosis and other causes for deterioration before administering glucocorticoids.
Journal ArticleDOI
Fungal Burden, Early Fungicidal Activity, and Outcome in Cryptococcal Meningitis in Antiretroviral-Naive or Antiretroviral-Experienced Patients Treated with Amphotericin B or Fluconazole
Tihana Bicanic,Graeme Meintjes,Robin Wood,Madeleine Hayes,Kevin Rebe,Linda-Gail Bekker,Thomas S. Harrison +6 more
TL;DR: Patients developing cryptococcal meningitis while already receiving antiretroviral therapy had lower baseline fungal burdens and a longer median duration of survival, but there were no differences observed in fungal clearance, cerebrospinal fluid proinflammatory cytokines, or 10-week mortality.
Journal ArticleDOI
Epidemiology of Cryptococcal Meningitis in the US: 1997–2009
Vasilios Pyrgos,Amy E. Seitz,Claudia A. Steiner,D. Rebecca Prevots,Peter R. Williamson,Peter R. Williamson +5 more
TL;DR: Cryptococcal meningitis remains a disease with significant morbidity and mortality in the U.S. and the relative burden among persons without HIV infection is increasing, and therelative burden among HIV-uninfected patients is increasing.
Journal ArticleDOI
Clinical features and serum biomarkers in HIV immune reconstitution inflammatory syndrome after cryptococcal meningitis: a prospective cohort study.
David R. Boulware,David B. Meya,David B. Meya,Tracy L. Bergemann,Darin L. Wiesner,Joshua Rhein,Abdu K Musubire,Sarah J. Lee,Andrew Kambugu,Andrew Kambugu,Edward N. Janoff,Paul R. Bohjanen +11 more
TL;DR: Clinical features in a prospective cohort with AIDS and recent cryptococcal meningitis after initiation of antiretroviral therapy are investigated to identify biomarkers for prediction and diagnosis of CM-IRIS (cryptococcal meninigitis-related immune reconstitution inflammatory syndrome).
Related Papers (5)
Multicenter Evaluation of BioFire FilmArray Meningitis/Encephalitis Panel for Detection of Bacteria, Viruses, and Yeast in Cerebrospinal Fluid Specimens
Amy Leber,Kathy Everhart,Joan-Miquel Balada-Llasat,Jillian Cullison,Judy A. Daly,Sarah Holt,Paul R. Lephart,Hossein Salimnia,Paul C. Schreckenberger,Sharon DesJarlais,Sharon L. Reed,Kimberle C. Chapin,Lindsay LeBlanc,J. Kristie Johnson,Nicole L. Soliven,Karen C. Carroll,Jo Anne Miller,Jennifer Dien Bard,Javier Mestas,Matthew J. Bankowski,Matthew J. Bankowski,Tori Enomoto,Andrew C. Hemmert,Kevin M. Bourzac +23 more