Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis
Giovanni Musso,Roberto Gambino,Franco De Michieli,Maurizio Cassader,Mario Rizzetto,Marilena Durazzo,Emanuela Fagà,Barbara Silli,Gianfranco Pagano +8 more
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TLDR
Dietary habits may promote steatohepatitis directly by modulating hepatic triglyceride accumulation and antioxidant activity as well as indirectly by affecting insulin sensitivity and postprandial triglyceride metabolism.About:
This article is published in Hepatology.The article was published on 2003-04-01 and is currently open access. It has received 703 citations till now. The article focuses on the topics: Postprandial & Saturated fat.read more
Citations
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Nonalcoholic fatty liver disease: From steatosis to cirrhosis
TL;DR: The present “gold standard” management of NASH is modest weight reduction, particularly correction of central obesity achieved by combining dietary measures with increased physical activity, which improves insulin resistance and reverses steatosis, hepatocellular injury, inflammation, and fibrosis.
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Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study
Christopher D. Williams,Joel Z. Stengel,Michael I. Asike,Dawn M. Torres,Janet Shaw,Maricela Contreras,Cristy L. Landt,Stephen A. Harrison +7 more
TL;DR: Prevalence of nonalcoholic fatty liver disease and NASH is higher than estimated previously and Hispanics and patients with diabetes are at greatest risk for both NAFLD and NASh.
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Risk of Cardiovascular Disease in Patients with Nonalcoholic Fatty Liver Disease
TL;DR: Growing evidence suggests that nonalcoholic fatty liver disease is associated with an increased risk of cardiovascular disease beyond that conferred by established risk factors.
Journal ArticleDOI
Nonalcoholic fatty liver disease
TL;DR: The etiology, pathogenesis and diagnosis of nonalcoholic fatty liver disease as well as approaches to its management are discussed in this paper, where the authors discuss the etiology and pathogenesis of NFLD.
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Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease.
Luca Miele,Venanzio Valenza,Giuseppe La Torre,Massimo Montalto,Giovanni Cammarota,Riccardo Ricci,Roberta Mascianà,Alessandra Forgione,M.L. Gabrieli,Germano Perotti,Fabio Maria Vecchio,Gian Lodovico Rapaccini,Giovanni Gasbarrini,Christopher P. Day,Antonio Grieco +14 more
TL;DR: In patients with NAFLD, both gut permeability and the prevalence of SIBO correlated with the severity of steatosis but not with presence of NASH, and the increased permeability appears to be caused by disruption of intercellular tight junctions in the intestine.
References
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Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Scott M. Grundy,David W. Bilheimer,Alan Chait,Luther T. Clark,Margo A. Denke,Richard J. Havel,William R. Hazzard,Stephen B. Hulley,Donald B. Hunninghake,Robert A. Kreisberg,Penny M. Kris-Etherton,James M. McKenney,Michael A. Newman,Ernst J. Schaefer,Burton E. Sobel,Carolyn Somelofski,Milton C. Weinstein,H. Bryan Brewer,James I. Cleeman,Karen A. Donato,Nancy D. Ernst,Jeffrey M. Hoeg,Basil M. Rifkind,Jacques E. Rossouw,Christopher T. Sempos,Joanne M. Gallivan,Maureen N. Harris,Laurie Quint-Adler +27 more
TL;DR: Dairy therapy remains the first line of treatment of high blood cholesterol, and drug therapy is reserved for patients who are considered to be at high risk for CHD, and the fundamental approach to treatment is comparable.
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Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.
TL;DR: A novel estimate of insulin sensitivity that is simple to calculate and provides a reasonable approximation of whole-body insulin sensitivity from the oral glucose tolerance test (OGTT).
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Nonalcoholic fatty liver disease.
TL;DR: Nonalcoholic fatty liver disease is associated with an increased risk of all-cause death, probably because of complications of insulin resistance such as vascular disease, as well as due to cirrhosis and hepatocellular carcinoma, which occurs in a minority of patients.
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Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
Steven A. Kliewer,Scott S. Sundseth,Stacey A. Jones,Peter Brown,G. Bruce Wisely,Cecilia S. Koble,Pallavi R. Devchand,Walter Wahli,Timothy M. Willson,James M. Lenhard,Jürgen M. Lehmann +10 more
TL;DR: Evidence that PPARs serve as physiological sensors of lipid levels is provided and a molecular mechanism whereby dietary fatty acids can modulate lipid homeostasis is suggested.
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Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM
TL;DR: Continuously elevated levels of plasma FFAs may play a key role in the pathogenesis of NIDDM in predisposed individuals by impairing peripheral glucose utilization and by promoting hepatic glucose overproduction.