Journal ArticleDOI
Differential Expression of Proteins during Healing of Cutaneous Wounds in Experimental Normal and Chronic Models
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TLDR
The proteins which were down regulated in chronic wounds may be used in the management of wounds and exploited as targets for therapeutic development.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1998-03-17. It has received 89 citations till now. The article focuses on the topics: Chronic wound & Fibroblast growth factor.read more
Citations
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Journal ArticleDOI
Regulation of Wound Healing by Growth Factors and Cytokines
Sabine Werner,Richard Grose +1 more
TL;DR: This review summarizes the results of expression studies that have been performed in rodents, pigs, and humans to localize growth factors and their receptors in skin wounds and reports on genetic studies addressing the functions of endogenous growth factors in the wound repair process.
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Growth factors and cytokines in wound healing.
TL;DR: A review of the specific roles of these growth factors and cytokines during wound healing can be found in this article, where patients are treated by three growth factors: PDGF-BB, bFGF, and GM-CSF.
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The role of vascular endothelial growth factor in wound healing.
TL;DR: Experimental data supports the hypothesis that VEGF stimulates epithelialization and collagen deposition in a wound, but likely promotes collagen deposition and epithelization as well, and stimulates wound healing through angiogenesis.
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Basic FGF mediates an immediate response of articular cartilage to mechanical injury.
TL;DR: Experiments with neutralizing Abs to bFGF and an FGFR1 tyrosine kinase inhibitor showed that this growth factor was the major ERK-activating factor released after injury, suggesting the presence of an extracellular store that is sequestered in the matrix and released upon damage.
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Can Thermal Lasers Promote Skin Wound Healing
Alexandre Capon,Serge Mordon +1 more
TL;DR: The analysis of the literature, and the fundamental considerations concerning the healing process when using thermal lasers, are in favor of a modification of the growth factors synthesis after laser irradiation, induced by an HSR.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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Vascular endothelial growth factor is a secreted angiogenic mitogen
TL;DR: DNA sequencing suggests the existence of several molecular species of VEGF, a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis in vivo.
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Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.
TL;DR: Small amounts of myoglobin, beta-lactoglobulin, and other proteins and peptides can be spotted or electroblotted onto polyvinylidene difluoride membranes, stained with Coomassie Blue, and sequenced directly, suggesting that PVDF membranes are superior supports for sequence analysis of picomole quantities of proteins purified by gel electrophoresis.
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Seminars in Medicine of the Beth Israel Hospital, Boston. Clinical applications of research on angiogenesis.
TL;DR: The realization that tumor growth requires new blood vessels and the identification of chemical factors that mediate angiogenesis have broadened the understanding of pathologic processes and opened new avenues to the diagnosis and treatment of these diseases.
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Vascular permeability factor, an endothelial cell mitogen related to PDGF
Pamela Jean Keck,Scott D. Hauser,Gwen G. Krivi,Kim Sanzo,Thomas G. Warren,Joseph Feder,Daniel T. Connolly +6 more
TL;DR: The cDNA sequence of VPF from human U937 cells was shown to code for a 189-amino acid polypeptide that is similar in structure to the B chain of platelet-derived growth factor (PD GF-B) and other PDGF-B-related proteins, suggesting that VPF appears to be related to the PDGF/v-sis family of proteins.