Book ChapterDOI
Distribution of cannabinoid receptors in the central and peripheral nervous system.
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TLDR
There is the need for detailed anatomical studies of brain regions important in the therapeutic actions of drugs that modify the endocannabinoid system and the determination of the localization of the enzymes that synthesize, degrade, and transport the endOCannabinoids.Abstract:
CB1 cannabinoid receptors appear to mediate most, if not all of the psychoactive effects of delta-9-tetrahydrocannabinol and related compounds. This G protein-coupled receptor has a characteristic distribution in the nervous system: It is particularly enriched in cortex, hippocampus, amygdala, basal ganglia outflow tracts, and cerebellum—a distribution that corresponds to the most prominent behavioral effects of cannabis. In addition, this distribution helps to predict neurological and psychological maladies for which manipulation of the endocannabinoid system might be beneficial. CB1 receptors are primarily expressed on neurons, where most of the receptors are found on axons and synaptic terminals, emphasizing the important role of this receptor in modulating neurotransmission at specific synapses. While our knowledge of CB1 localization in the nervous system has advanced tremendously over the past 15 years, there is still more to learn. Particularly pressing is the need for (1) detailed anatomical studies of brain regions important in the therapeutic actions of drugs that modify the endocannabinoid system and (2) the determination of the localization of the enzymes that synthesize, degrade, and transport the endocannabinoids.read more
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Journal ArticleDOI
Exposure to cannabinoid agonist WIN 55,212-2 during early adolescence increases alcohol preference and anxiety in CD1 mice.
Jimena Laura Frontera,Jimena Laura Frontera,Victoria María Gonzalez Pini,Fernando Luis Messore,Alicia Brusco +4 more
TL;DR: Exposure to WIN in early adolescence can affect neural development and induce alcohol preference and anxiety‐like behavior during late adolescence, demonstrating that exposure to WIN during adolescence has long‐lasting effects in neural development.
Journal ArticleDOI
1,4-Diazepane compounds as potent and selective CB2 agonists: optimization of metabolic stability.
Doris Riether,Lifen Wu,Pier F. Cirillo,Angela Berry,Edward Walker,Monika Ermann,Beatriz Noya-Marino,Jenkins James Edward,Dan Albaugh,Claudia Albrecht,Michael B. Fisher,Mark J. Gemkow,Heather Grbic,Sabine Löbbe,Clemens Möller,Kathy O’Shea,Achim Sauer,Daw-Tsun Shih,David S. Thomson +18 more
TL;DR: A high-throughput screening campaign has identified 1,4-diazepane compounds which are potent Cannabinoids receptor 2 agonists with excellent selectivity against the Cannabinoid receptor 1 with a good stability in liver microsomes and rat PK profile.
Journal ArticleDOI
Kynurenines and the Endocannabinoid System in Schizophrenia: Common Points and Potential Interactions
Ferenc Zádor,Gábor Nagy-Grócz,Gabriella Kekesi,Szabolcs Dvorácskó,Edina Szűcs,Csaba Tömböly,Gyongyi Horvath,Sándor Benyhe,László Vécsei +8 more
TL;DR: The present study focuses on the main common points and potential interactions between kynurenines and the ECS in schizophrenia, which include the regulation of glutamatergic/dopaminergic/γ-aminobutyric acidergic neurotransmission, their presence in astrocytes, and their role in inflammatory mechanisms.
Book ChapterDOI
Cannabinoids and the Cannabinoid Receptors: An Overview
Dai Lu,D.E. Potter +1 more
TL;DR: Besides the plant-derived cannabinoids (phytocannabinoids), a group of endogenous lipid-derived molecules can similarly activate the cannabinoid receptors; therefore they are referred to as endocannabinoids, and an overview of cannabinoid receptors is provided.
Journal ArticleDOI
Antidepressant-like effects of pharmacological inhibition of FAAH activity in socially isolated female rats
Luca Carnevali,Rosario Statello,Federica Vacondio,Francesca Ferlenghi,Gilberto Spadoni,Silvia Rivara,Marco Mor,Andrea Sgoifo +7 more
TL;DR: A potential interplay between AEA-mediated signaling and hippocampal BDNF in the pathogenesis of depression-relevant behaviors and physiological alterations and antidepressant action of FAAH inhibition in socially isolated female rats is suggested.
References
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Journal ArticleDOI
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
TL;DR: The cloning and expression of a complementary DNA that encodes a G protein-coupled receptor that is involved in cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana are suggested.
Journal ArticleDOI
Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study
TL;DR: The results suggest that the presently characterized cannabinoid receptor mediates physiological and behavioral effects of natural and synthetic cannabinoids, because it is strongly coupled to guanine nucleotide regulatory proteins and is discretely localized to cortical, basal ganglia, and cerebellar structures involved with cognition and movement.
Journal ArticleDOI
The endogenous cannabinoid system controls extinction of aversive memories
Giovanni Marsicano,Carsten T. Wotjak,Shahnaz Christina Azad,Shahnaz Christina Azad,Tiziana Bisogno,Gerhard Rammes,Maria Grazia Cascio,Heike Hermann,Jianrong Tang,Clementine Hofmann,Walter Zieglgänsberger,Vincenzo Di Marzo,Beat Lutz +12 more
TL;DR: Treatment of wild-type mice with the CB1 antagonist SR141716A mimicked the phenotype of CB1-deficient mice, revealing that CB1 is required at the moment of memory extinction, and proposes that endocannabinoids facilitate extinction of aversive memories through their selective inhibitory effects on local inhibitory networks in the amygdala.
Journal ArticleDOI
Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system.
TL;DR: The results generally agree well with the previous studies using CB1 receptor autoradiography and messenger RNA in situ hybridization, but because of its greater resolution, immunohistochemistry allowed identification of particular neuronal cells and fibers that possess cannabinoid receptors.